{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T05:04:43Z","timestamp":1698555883189},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,1,17]],"date-time":"2008-01-17T00:00:00Z","timestamp":1200528000000},"content-version":"vor","delay-in-days":3913,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A procedure for the isolation of the toxin Tityustoxin VII (TsTX\u2010VII) from Tityus serrulatus scorpion venom and its biochemical characterization is reported. This protein has a Mr=6,700\u20106,800, eight half\u2010cystine residues accounting for four disulfide bridges and no His. Its N\u2010terminal sequence GHZGYGS \u2026 characterizes it as a new toxin, able to release glutamic acid and gamma aminobutyric acid from rat brain synaptosomes \u201cin vitro\u201d. This release was also induced by the whole venom. Tetrodotoxin however blocked the effect of the whole venom but not that of TsTX\u2010VII, thus suggesting that the releasing mechanism by TsTX\u2010VII does not involve Na+ but perhaps K+ or Ca++ channels.<\/jats:p>","DOI":"10.1080\/15216549700202351","type":"journal-article","created":{"date-parts":[[2007,7,7]],"date-time":"2007-07-07T11:40:38Z","timestamp":1183808438000},"page":"1255-1263","source":"Crossref","is-referenced-by-count":0,"title":["TsTX\u2010VII, a new toxin from Tityus serrulatus scorpion venom able to induce the release of neurotransmitters from rat brain synaptosomes not blocked by tetrodotoxin"],"prefix":"10.1002","volume":"41","author":[{"given":"Suely V.","family":"Sampaio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Coutinho\u2010Netto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane C.","family":"Arantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos H.","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 C.","family":"Novello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 R.","family":"Giglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,17]]},"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F15216549700202351","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/15216549700202351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T04:14:33Z","timestamp":1698466473000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1080\/15216549700202351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,5]]}},"alternative-id":["10.1080\/15216549700202351"],"URL":"https:\/\/doi.org\/10.1080\/15216549700202351","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5]]}}}