{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:11:26Z","timestamp":1770703886012,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,17]],"date-time":"2008-01-17T00:00:00Z","timestamp":1200528000000},"content-version":"vor","delay-in-days":3760,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We measured the levels of interleukin\u20106 (IL\u20106), albumin, C\u2010reactive protein (CRP) and \u03b12 macroglobulin (\u03b12M), all of which have different spectrums of molecular weight, in the cerebrospinal fluid (CSF) and serum in 121 patients to evaluate damage to the blood\u2010cerebrospinal fluid barrier (BCB) in meningitis. There was an extraordinary high level of IL\u20106 in the CSF when patients had bacterial or viral meningitis, but the level returned to a normal range within a week in almost all of these cases. There were no significant differences in CSF albumin levels among the different disease groups. The CRP level in CSF is considered to correlate with the serum level, and CSF CRP was higher in bacterial meningitis than in viral meningitis, however, CRP in CSF was increased in some of the infectious diseases without meningitis. The \u03b12M in CSF, which tends to be at extraordinarily high levels when there is damage to the BCB, correlated highly with CSF cell counts. CSF IL\u20106 seemed to be a useful indicator to identify the acute active phase of meningitis. CRP and \u03b12M in CSF are considered to be useful to differentiate bacterial meningitis, bacterial infection without meningitis and viral meningitis. Extraordinarily high levels of \u03b12M, which has a high molecular weight, in CSF is indicative of BCB damage.<\/jats:p>","DOI":"10.1080\/15216549700204051","type":"journal-article","created":{"date-parts":[[2007,7,7]],"date-time":"2007-07-07T11:42:08Z","timestamp":1183808528000},"page":"269-278","source":"Crossref","is-referenced-by-count":1,"title":["Levels of interleukin\u20106, CRP and \u03b12 macroglobulin in cerebrospinal fluid (CSF) and serum as indicator of blood\u2010 CSF barrier damage"],"prefix":"10.1002","volume":"43","author":[{"given":"Yuhsaku","family":"Kanoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ohtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,17]]},"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F15216549700204051","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/15216549700204051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T23:44:42Z","timestamp":1698450282000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1080\/15216549700204051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["10.1080\/15216549700204051"],"URL":"https:\/\/doi.org\/10.1080\/15216549700204051","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}