{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T14:52:29Z","timestamp":1717944749561},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,17]],"date-time":"2008-01-17T00:00:00Z","timestamp":1200528000000},"content-version":"vor","delay-in-days":3425,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of various organic acids on hydroxyl radical (\u00b7 OH) generation in the Fenton reaction were examined by the ESR spin trapping technique, where 5,5\u2010dimethyl\u20101\u2010pyroline\u2010N\u2010nitroxide (DMPO) and \u03b1\u2010phenyl\u2010tert\u2010 butyl nitrone (PBN) were used as the spin trapping reagents. \u03b1\u2010Hydroxy acids such as lactic acid, glycolic acid and 2\u2010hydroxy isobutyric acid were found to markedly enhance \u00b7 OH generation in the reaction. In contrast, \u03b2\u2010hydroxy acid, \u03b1\u2010keto acid, esters of \u03b1\u2010hydroxy acids, aldehydes and other straight chain organic acids had no such enhancing activity, \u03b1\u2010Amino acids had also no enhancing effect. The results suggest that the \u03b1\u2010hydroxy acid moiety is prerequisite for the enhancement of \u00b7 OH generation in the Fenton reaction. Superoxide dismutase did not inhibit the enhancing effect of \u03b1\u2010hydroxy acids whereas catalase completely inhibited the \u00b7 OH generation. Thus, \u03b1\u2010hydroxy acids directly enhanced the \u00b7 OH generation via the Fenton reaction but not the Haber\u2010Weiss reaction. Possible role of lactic acid manipulating \u00b7 OH generation is discussed in relation to the ischemia\u2010reperfusion cell damage.<\/jats:p>","DOI":"10.1080\/15216549800203642","type":"journal-article","created":{"date-parts":[[2007,7,7]],"date-time":"2007-07-07T11:45:51Z","timestamp":1183808751000},"page":"137-145","source":"Crossref","is-referenced-by-count":4,"title":["Enhancement of hydroxyl radical generation in the fenton reaction by alpha\u2010hydroxy acid"],"prefix":"10.1002","volume":"46","author":[{"given":"M. Aktar","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,17]]},"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F15216549800203642","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/15216549800203642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T20:21:33Z","timestamp":1698524493000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1080\/15216549800203642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["10.1080\/15216549800203642"],"URL":"https:\/\/doi.org\/10.1080\/15216549800203642","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}