{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T04:56:43Z","timestamp":1698555403627},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T00:00:00Z","timestamp":1200614400000},"content-version":"vor","delay-in-days":3304,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The enzyme steroid sulfatase (STS) hydrolyses 3\u2010beta\u2010hydroxysteroid sulfates. The female\u2010male STS activity ratio is 1.04\u20101.7:1 in several cell lines in adults and reaches 2\u2026n1 in prepubertal subjects. In fibroblasts, STS values in X\u2010chromosome abnormalities show a partial positive correlation according to the number of X\u2010chromosomes. X\u2010linked ichthyosis (XLI) carriers, with only one copy of the STS gene, present lower STS levels than normal controls. This study analyzes the STS activity in leukocytes of 46,Xi(Xq); 45,X; XLI carriers and normal controls using 7\u2010[3H]\u2010dehydroepiandrosterone sulfate as substrate. X\u2010monosomy (1.07\u00b10.18 pmol\/mg protein\/h), Xq isochromosome (1.02\u00b10.12 pmol\/mg protein\/h) and normal females (1.03\u00b10.11 pmol\/mg protein\/h) had similar STS values (p&gt;0.05). XLI\u2010carriers and males showed the lowest STS levels (0.34\u00b10.04 pmol\/mg protein\/h, p&lt;0.001 and 0.82\u00b10.14 pmol\/mg protein\/h, p&lt;0.05, respectively). Female\u2010male STS activity ratio in leukocytes was 1.3\u2026n1. These data indicate that a complex mechanism regulates the STS expression depending on each type of cell line.<\/jats:p>","DOI":"10.1080\/15216549900201133","type":"journal-article","created":{"date-parts":[[2007,7,7]],"date-time":"2007-07-07T11:47:18Z","timestamp":1183808838000},"page":"137-142","source":"Crossref","is-referenced-by-count":0,"title":["Steroid sulfatase activity in leukocytes: a comparative study in 45,X; 46,Xi(Xq) and carriers of steroid sulfatase deficiency"],"prefix":"10.1002","volume":"47","author":[{"given":"Antonio","family":"Miranda\u2010Duarte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Vald\u00e9s\u2010Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Miranda\u2010Zamora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"D\u00edaz\u2010Zagoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana H.","family":"Kofman\u2010Alfaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio A.","family":"Cuevas\u2010Covarrubias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,18]]},"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F15216549900201133","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/15216549900201133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T19:07:56Z","timestamp":1698520076000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1080\/15216549900201133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.1080\/15216549900201133"],"URL":"https:\/\/doi.org\/10.1080\/15216549900201133","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}