{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:05:03Z","timestamp":1793361903819,"version":"4.5.0"},"reference-count":66,"publisher":"Informa UK Limited","issue":"3-4","license":[{"start":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:00:00Z","timestamp":1569974400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pain & Palliative Care Pharmacotherapy"],"published-print":{"date-parts":[[2019,10,2]]},"DOI":"10.1080\/15360288.2019.1668902","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T11:21:11Z","timestamp":1571052071000},"page":"82-97","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":65,"title":["Opioid-related respiratory and gastrointestinal adverse events in patients with acute postoperative pain: prevalence, predictors, and burden"],"prefix":"10.1080","volume":"33","author":[{"given":"Gary M.","family":"Oderda","sequence":"first","affiliation":[{"name":"College of Pharmacy, University of Utah","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Homer Stryker School of Medicine, Borgess Medical Center\/Western Michigan University","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Xcenda, LLC","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Trevena, Inc","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Duke University Medical Center","place":["Salt Lake City, USA; Anthony J. Senagore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Senagore","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Utah","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Homer Stryker School of Medicine, Borgess Medical Center\/Western Michigan University","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Xcenda, LLC","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Trevena, Inc","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Duke University Medical Center","place":["Salt Lake City, USA; Anthony J. Senagore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie","family":"Morland","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Utah","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Homer Stryker School of Medicine, Borgess Medical Center\/Western Michigan University","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Xcenda, LLC","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Trevena, Inc","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Duke University Medical Center","place":["Salt Lake City, USA; Anthony J. Senagore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh Usman","family":"Iqbal","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Utah","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Homer Stryker School of Medicine, Borgess Medical Center\/Western Michigan University","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Xcenda, LLC","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Trevena, Inc","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Duke University Medical Center","place":["Salt Lake City, USA; Anthony J. Senagore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marla","family":"Kugel","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Utah","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Homer Stryker School of Medicine, Borgess Medical Center\/Western Michigan University","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Xcenda, LLC","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Trevena, Inc","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Duke University Medical Center","place":["Salt Lake City, USA; Anthony J. Senagore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhu","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Utah","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Homer Stryker School of Medicine, Borgess Medical Center\/Western Michigan University","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Xcenda, LLC","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Trevena, Inc","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Duke University Medical Center","place":["Salt Lake City, USA; Anthony J. Senagore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf S.","family":"Habib","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Utah","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Homer Stryker School of Medicine, Borgess Medical Center\/Western Michigan University","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Xcenda, LLC","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Trevena, Inc","place":["Salt Lake City, USA; Anthony J. Senagore"]},{"name":"Duke University Medical Center","place":["Salt Lake City, USA; Anthony J. Senagore"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.12.008"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1223"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H386"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540280039031"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S144066"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181c38c25"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2010.09.003"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181e2c1d9"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000564"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150214"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000002"},{"key":"e_1_3_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bja.a013383"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199909000-00022"},{"key":"e_1_3_1_15_1","first-page":"361","article-title":"Postoperative nausea and vomiting (PONV): usefulness of the Apfel-score for identification of high risk patients for PONV","volume":"57","author":"Weilbach C","year":"2006","unstructured":"Weilbach C, Rahe-Meyer N, Raymondos K, Weissig A, Scheinichen D, Piepenbrock S. Postoperative nausea and vomiting (PONV): usefulness of the Apfel-score for identification of high risk patients for PONV. Acta Anaesthesiol Belg. 2006;57:361\u20133.","journal-title":"Acta Anaesthesiol Belg"},{"key":"e_1_3_1_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/15360288.2012.751956"},{"key":"e_1_3_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes276"},{"key":"e_1_3_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2011.06.008"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000672"},{"key":"e_1_3_1_20_1","unstructured":"The Joint Commission. Safe use of opioids in hospitals. 2012. [accessed 2018 Jun 5]. https:\/\/www.jointcommission.org\/assets\/1\/18\/SEA_49_opioids_8_2_12_final.pdf."},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001416"},{"key":"e_1_3_1_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001178"},{"key":"e_1_3_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.07.015"},{"key":"e_1_3_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03009805"},{"key":"e_1_3_1_25_1","doi-asserted-by":"crossref","first-page":"E827","DOI":"10.36076\/ppj.2015\/18\/E827","article-title":"Incidence and demographics of post-operative naloxone administration: a 13-year experience at a major tertiary teaching institution","volume":"18","author":"Khelemsky Y","year":"2015","unstructured":"Khelemsky Y, Kothari R, Campbell N, Farnad S. Incidence and demographics of post-operative naloxone administration: a 13-year experience at a major tertiary teaching institution. Pain Phys. 2015;18:E827\u20139.","journal-title":"Pain Phys"},{"key":"e_1_3_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2004.12.003"},{"key":"e_1_3_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes447"},{"key":"e_1_3_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2004.02.021"},{"key":"e_1_3_1_29_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt.14.19"},{"key":"e_1_3_1_30_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000792"},{"key":"e_1_3_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40140-013-0047-0"},{"key":"e_1_3_1_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-015-2082-0"},{"key":"e_1_3_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.12.005"},{"key":"e_1_3_1_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e32833f53b8"},{"key":"e_1_3_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_3_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00585-1"},{"key":"e_1_3_1_37_1","unstructured":"Averill RF Goldfield N Hughes JS Averill RF Goldfield N Hughes JS Bonazelli J McCullough EC Mullin R Tang AM. 3MTM APR DRG Classification System Version 26.1 (effective 10\/01\/2008). Methodology Overview. GRP-041 2008. [accessed 2018 Jun 5]. https:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nis\/v261_aprdrg_meth_ovrview.pdf."},{"key":"e_1_3_1_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31823c1030"},{"key":"e_1_3_1_39_1","volume-title":"Annual Scientific Meeting of the American Society of Colon and Rectal Surgeons (ASCRS)","author":"Senagore A","year":"2018","unstructured":"Senagore A, Oderda G, Morland K, Iqbal S, Kugel M, Liu S, Habib A. Prevalence and burden of opioid-induced respiratory depression and postoperative nausea\/vomiting associated with the treatment of acute postoperative pain following general\/colorectal surgery. Annual Scientific Meeting of the American Society of Colon and Rectal Surgeons (ASCRS); May 19-23, 2018. Nashville, TN."},{"key":"e_1_3_1_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2017.1263139"},{"key":"e_1_3_1_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.1039"},{"key":"e_1_3_1_42_1","doi-asserted-by":"publisher","DOI":"10.17140\/AOJ-2-109"},{"key":"e_1_3_1_43_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000836"},{"key":"e_1_3_1_44_1","unstructured":"Weinger MB. Dangers of postoperative opioids: APSF Workshop and white paper address prevention of postoperative respiratory complications 2007. [accessed 2018 Oct 31]. http:\/\/www.apsf.org\/newsletters\/html\/2007\/winter\/01_opioids.htm."},{"key":"e_1_3_1_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1103900405"},{"key":"e_1_3_1_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh180"},{"key":"e_1_3_1_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200504000-00018"},{"key":"e_1_3_1_48_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S137952"},{"key":"e_1_3_1_49_1","doi-asserted-by":"crossref","unstructured":"Viscusi ER Skobieranda F Soergel DG Cook E Burt DA Singla N. APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130) a G protein-biased ligand at the micro-opioid receptor for management of moderate-to-severe acute pain following bunionectomy. J Pain Res. 2019;12:927\u201343.","DOI":"10.2147\/JPR.S171013"},{"key":"e_1_3_1_50_1","doi-asserted-by":"crossref","unstructured":"Singla NK Skobieranda F Soergel DG Salamea M Burt DA Demitrack MA Viscusi ER. APOLLO-2: a randomized placebo and active-controlled Phase III study investigating oliceridine (TRV130) a G protein-biased ligand at the mu-opioid receptor for management of moderate to severe acute pain following abdominoplasty. Pain Pract: The Official J World Institute Pain. 2019;19(7):715\u201331..","DOI":"10.1111\/papr.12801"},{"key":"e_1_3_1_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-024086"},{"key":"e_1_3_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(02)00691-7"},{"key":"e_1_3_1_53_1","first-page":"A0787","volume-title":"23rd ESICM Annual Congress","author":"Bloom JD","year":"2010","unstructured":"Bloom JD, Lu M, Sigl JC, Hansell DM. Postoperative naloxone rescue following parenteral opioids after abdominal surgery: incidence and cohort morbidity and mortality. 23rd ESICM Annual Congress 2010. Oct 9-13; Barcelona, Spain p. A0787."},{"key":"e_1_3_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2003.11.002"},{"key":"e_1_3_1_55_1","unstructured":"Overdyk FJ. Postoperative respiratory depression and opioids. 2009. [accessed 2018 May 27]. http:\/\/www.initiatives-patientsafety.org\/assets\/initiatives1.pdf."},{"key":"e_1_3_1_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006416-200401000-00007"},{"key":"e_1_3_1_57_1","first-page":"21","article-title":"No patient shall be harmed by opioid-induced respiratory depression [Proceedings of \u201cEssential monitoring strategies to detect clinically significant drug-induced respiratory depression in the postoperative period\u201d conference]","volume":"26","author":"Weinger MB","year":"2011","unstructured":"Weinger MB, Lee LA. No patient shall be harmed by opioid-induced respiratory depression [Proceedings of \u201cEssential monitoring strategies to detect clinically significant drug-induced respiratory depression in the postoperative period\u201d conference]. Anesth Patient Saf Found Newslett. 2011;26:21\u20138.","journal-title":"Anesth Patient Saf Found Newslett"},{"key":"e_1_3_1_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/qshc.2007.022210"},{"key":"e_1_3_1_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000565"},{"key":"e_1_3_1_60_1","doi-asserted-by":"publisher","DOI":"10.1054\/jpai.2002.123652"},{"key":"e_1_3_1_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.2012.01101.x"},{"key":"e_1_3_1_62_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181823efb"},{"key":"e_1_3_1_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199909000-00022"},{"key":"e_1_3_1_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002008"},{"key":"e_1_3_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.09.074"},{"key":"e_1_3_1_66_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X104830"},{"key":"e_1_3_1_67_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S4243"}],"container-title":["Journal of Pain & Palliative Care Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15360288.2019.1668902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/15360288.2019.1668902","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15360288.2019.1668902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:53:11Z","timestamp":1789465991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15360288.2019.1668902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,2]]},"references-count":66,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2019,10,2]]}},"alternative-id":["10.1080\/15360288.2019.1668902"],"URL":"https:\/\/doi.org\/10.1080\/15360288.2019.1668902","relation":{},"ISSN":["1536-0288","1536-0539"],"issn-type":[{"value":"1536-0288","type":"print"},{"value":"1536-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ippc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ippc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}