{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:04:14Z","timestamp":1782122654465,"version":"3.54.5"},"reference-count":53,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Mechanisms and Methods"],"published-print":{"date-parts":[[2020,2,12]]},"DOI":"10.1080\/15376516.2019.1669243","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T15:16:22Z","timestamp":1568819782000},"page":"115-123","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":36,"title":["Zinc abrogates anticancer drug tamoxifen-induced hepatotoxicity by suppressing redox imbalance, NO\/iNOS\/NF-\u0138B signaling, and caspase-3-dependent apoptosis in female rats"],"prefix":"10.1080","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-9964","authenticated-orcid":false,"given":"Ademola C.","family":"Famurewa","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Alex Ekwueme Federal University, Ikwo, Nigeria;"},{"name":"Biochemistry Division, Amala Cancer Research Centre, Amala Institute of Medical Sciences, Thrissur, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chima A.","family":"Ekeleme-Egedigwe","sequence":"additional","affiliation":[{"name":"Department of Chemistry\/Biochemistry and Molecular Biology, Faculty of Science, Alex-Ekwueme Federal University, Ikwo, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebuka E.","family":"David","sequence":"additional","affiliation":[{"name":"Department of Chemistry\/Biochemistry and Molecular Biology, Faculty of Science, Alex-Ekwueme Federal University, Ikwo, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinedum O.","family":"Eleazu","sequence":"additional","affiliation":[{"name":"Department of Chemistry\/Biochemistry and Molecular Biology, Faculty of Science, Alex-Ekwueme Federal University, Ikwo, Nigeria;"},{"name":"Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiola M.","family":"Folawiyo","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Basic Medical Sciences, Ekiti State University, Ado-Ekiti, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nwogo A.","family":"Obasi","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Alex Ekwueme Federal University, Ikwo, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"CIT0001","first-page":"276","volume-title":"Methods in enzymatic analysis","author":"Aebi H","year":"1983"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22254"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.04.021"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-282"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.18110"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.12.014"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2018-0070"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2017.06.026"},{"key":"CIT0009","unstructured":"Beutler E. 1975. Glutathione in red blood cell metabolism. A manual of biochemical methods. New York: Grunee and Stratton; p. 112\u2013114."},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2011.560780"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-011-0775-1"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(93)90420-5"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S124016"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1556\/AVet.2011.020"},{"issue":"3","key":"CIT0015","first-page":"280","volume":"48","author":"El-Beshbishy HA","year":"2010","journal-title":"Indian J Exp Biol"},{"issue":"5","key":"CIT0016","first-page":"175","volume":"2","author":"El-Beshbishy HA","year":"2007","journal-title":"Asian J Trad Med"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2018.05.001"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1089\/act.2017.29147.yhk"},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"189","DOI":"10.21608\/ejhm.2005.18121","volume":"19","author":"Gawish AM","year":"2005","journal-title":"Egypt J Hosp Med"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.03.041"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.088"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6580.172289"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12398"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143098"},{"issue":"1","key":"CIT0026","first-page":"785.14","volume":"29","author":"Koladia M","year":"2015","journal-title":"FASEB J"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2014.12.014"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.12.098"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.02.055"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03714.x"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0773-6"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.5812\/jjhs.21717"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.5.1432S"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392207"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22327"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.05.009"},{"key":"CIT1000","unstructured":"Paglia DE, Valentine WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 70:158\u2013169."},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.01996.x"},{"issue":"2","key":"CIT0039","first-page":"219","volume":"2","author":"Rahman K","year":"2007","journal-title":"Clin Interv Aging"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopr.2013.03.003"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22293"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-016-9911-y"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1007\/s12298-012-0139-1"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.179365"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1159\/000348547"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1177\/0748233718770293"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0148"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2013.876053"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1080\/713611034"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0852-z"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1177\/0960327116637414"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1159\/000479539"}],"container-title":["Toxicology Mechanisms and Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15376516.2019.1669243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T20:09:06Z","timestamp":1620331746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15376516.2019.1669243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,12]]}},"alternative-id":["10.1080\/15376516.2019.1669243"],"URL":"https:\/\/doi.org\/10.1080\/15376516.2019.1669243","relation":{},"ISSN":["1537-6516","1537-6524"],"issn-type":[{"value":"1537-6516","type":"print"},{"value":"1537-6524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}