{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T10:43:21Z","timestamp":1780742601480,"version":"3.54.1"},"reference-count":27,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Mechanisms and Methods"],"published-print":{"date-parts":[[2020,2,12]]},"DOI":"10.1080\/15376516.2019.1672122","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T08:09:52Z","timestamp":1569398992000},"page":"139-145","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Cerebrospinal fluid neurotransmitter levels and central nervous system depression in a rat drug overdose model"],"prefix":"10.1080","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-4079","authenticated-orcid":false,"given":"Hiroshi","family":"Tsutsumi","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosei","family":"Yonemitsu","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-0645","authenticated-orcid":false,"given":"Ako","family":"Sasao","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Ohtsu","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Nishitani","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1159\/000337028"},{"key":"CIT0002","first-page":"1","volume":"358","author":"Council of European Communities.","year":"1986","journal-title":"Off J Eur Commun"},{"key":"CIT0003","unstructured":"Hedegaard H, Warner M, Mini\u00f1o AM. 2017. Drug overdose deaths in the United States, 1999\u20132016. NCHS Data Brief. 273:1\u20138. https:\/\/www.cdc.gov\/nchs\/data\/databriefs\/db294.pdf."},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.2131\/jts.41.765"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12275"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2017.01.004"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.2.181"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600601109"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2013.10.027"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90002-X"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.11.022"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1038\/srep07796"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.je.2016.08.010"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2015.07.006"},{"issue":"3","key":"CIT0015","first-page":"361","volume":"119","author":"Shore PA","year":"1957","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1038\/260718a0"},{"key":"CIT0017","volume-title":"Handbook of toxicology: acute toxicities of solids, liquids and gases in laboratory animals","author":"Spector WS","year":"1956"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68241"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.54.193"},{"key":"CIT0020","unstructured":"Teva Takeda Pharma Ltd. 2017. Pharmaceutical interview forms of cercine tablets, powder, and syrup."},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91639-0"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2015.01.001"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2008.10.020"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(02)13011-7"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.3109\/15563659809028944"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2009.05.027"},{"issue":"9","key":"CIT0027","first-page":"1261","volume":"25","author":"Yamatogi Y","year":"1993","journal-title":"Jpn J Pediatr Med"}],"container-title":["Toxicology Mechanisms and Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15376516.2019.1672122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T20:10:08Z","timestamp":1620331808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15376516.2019.1672122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,10]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,12]]}},"alternative-id":["10.1080\/15376516.2019.1672122"],"URL":"https:\/\/doi.org\/10.1080\/15376516.2019.1672122","relation":{},"ISSN":["1537-6516","1537-6524"],"issn-type":[{"value":"1537-6516","type":"print"},{"value":"1537-6524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,10]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}