{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:55:07Z","timestamp":1781765707586,"version":"3.54.5"},"reference-count":87,"publisher":"Informa UK Limited","issue":"10","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"unspecified","delay-in-days":269,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005366","name":"American Foundation for Aging Research","doi-asserted-by":"publisher","award":["AFAR Research Grants for Junior Faculty"],"award-info":[{"award-number":["AFAR Research Grants for Junior Faculty"]}],"id":[{"id":"10.13039\/100005366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/P007856\/1"],"award-info":[{"award-number":["BB\/P007856\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/L006324\/1"],"award-info":[{"award-number":["BB\/L006324\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG058741"],"award-info":[{"award-number":["AG058741"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL132241"],"award-info":[{"award-number":["R01 HL132241"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00 AG048016"],"award-info":[{"award-number":["R00 AG048016"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL054732"],"award-info":[{"award-number":["R01 HL054732"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Autophagy"],"published-print":{"date-parts":[[2020,10,2]]},"DOI":"10.1080\/15548627.2019.1704117","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T05:48:48Z","timestamp":1577684928000},"page":"1807-1822","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":73,"title":["TGFB-INHB\/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2"],"prefix":"10.1080","volume":"16","author":[{"given":"Kai","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia P.","family":"Sagona","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Warwick, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis P.","family":"Nezis","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Warwick, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Bodmer","sequence":"additional","affiliation":[{"name":"Development, Aging, and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-0119","authenticated-orcid":false,"given":"Karen","family":"Ocorr","sequence":"additional","affiliation":[{"name":"Development, Aging, and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2221-7545","authenticated-orcid":false,"given":"Hua","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,12,29]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4179"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.246876"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048893.62841.F7"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.030"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.159"},{"key":"cit0006","volume":"6","author":"Chang JT","year":"2017","journal-title":"Elife"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.5.11947"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.004"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.4161\/auto.22971"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvt047"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2009.00504.x"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.09.014"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv252"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.03.010"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1126\/science.1115535"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12256"},{"key":"cit0017","author":"Upadhyay A","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"cit0018","first-page":"158","volume":"2","author":"Biernacka A","year":"2011","journal-title":"Aging Dis"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04994-z"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003941"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.05.001"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.2144\/000113078"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.07.053"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.07.009"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1221565"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164239"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1038\/srep25252"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1063766"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1100356"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8007"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200711108"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1126\/science.1182228"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1038\/nature11861"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000057979.36322.88"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.248260"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.05.013"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.03.013"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302455110"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106148"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1038\/nature02549"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.10.007"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1038\/nature12143"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3810"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-7-15"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.058"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(01)00117-6"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000120704.97934.41"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.04.012"},{"key":"cit0049","author":"Tsai YL","journal-title":"Am J Hypertens"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.06.017"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001020"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.02.002"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01048.2009"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.872200"},{"key":"cit0055","author":"Liu M","journal-title":"Int J Mol Sci"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319116111"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.08.064"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.01.001"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.1.7279"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.10.050"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.05.005"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3407"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75051"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.14.16586"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.04.001"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp384"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.559"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.11.001"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.4161\/15548627.2014.981789"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1775409"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.04.007"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.168724"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1101\/gad.203406.112"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.179390"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12425"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00338.2010"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.03.008"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.1.98"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02711"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1101\/gad.901101"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.04.086"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01899"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00361-6"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012080769"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003081"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044214"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2009.05.004"}],"container-title":["Autophagy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15548627.2019.1704117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T02:01:52Z","timestamp":1620612112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15548627.2019.1704117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,29]]},"references-count":87,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10,2]]}},"alternative-id":["10.1080\/15548627.2019.1704117"],"URL":"https:\/\/doi.org\/10.1080\/15548627.2019.1704117","relation":{},"ISSN":["1554-8627","1554-8635"],"issn-type":[{"value":"1554-8627","type":"print"},{"value":"1554-8635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,29]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kaup20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kaup20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}