{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:11:58Z","timestamp":1791443518830,"version":"4.3.3"},"reference-count":66,"publisher":"Informa UK Limited","issue":"10","funder":[{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","award":["Jun Hee Lee"],"award-info":[{"award-number":["Jun Hee Lee"]}],"id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","award":["Jun Hee Lee"],"award-info":[{"award-number":["Jun Hee Lee"]}],"id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","award":["Jun Hee Lee"],"award-info":[{"award-number":["Jun Hee Lee"]}],"id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AG045432, R01DK114131, R01DK111465 and R01DK102850"],"award-info":[{"award-number":["R21AG045432, R01DK114131, R01DK111465 and R01DK102850"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01AG061236"],"award-info":[{"award-number":["K01AG061236"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Autophagy"],"published-print":{"date-parts":[[2022,10,3]]},"DOI":"10.1080\/15548627.2021.2016255","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T16:44:36Z","timestamp":1640796276000},"page":"2303-2322","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":14,"title":["Simultaneous loss of TSC1 and DEPDC5 in skeletal and cardiac muscles produces early-onset myopathy and cardiac dysfunction associated with oxidative damage and SQSTM1\/p62 accumulation"],"prefix":"10.1080","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-5745","authenticated-orcid":false,"given":"Chun-Seok","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Rye","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3082-8995","authenticated-orcid":false,"given":"Carol","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan V.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-6011","authenticated-orcid":false,"given":"Jun Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myungjin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2012.12.005"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1212704"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.08.006"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.10.002"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12336"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.03.015"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12496"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1101-1014"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.142166599"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.218255"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0205-1"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080281"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.168922"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12943"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.058"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005970"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80155-0"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.096222"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065874"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1126\/science.1182228"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-031620-092317"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201900221"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.08.026"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.11.004"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(03)00138-2"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32833862df"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196371"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2152"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.11.020"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.027"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00142-4"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.07.061"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200301001-00011"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705430"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.07.007"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00141-19"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2018.02.021"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1140293"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2757"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.04.005"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3311"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.6.15123"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01279-8"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.88"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12905"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.11.001"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7670"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.021"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01645-7"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2021"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.07.034"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00441-17"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.03.029"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.05.011"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-019-0131-9"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201100131"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5241"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00372.2009"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13442-5"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.38.1.1"},{"key":"cit0061","volume-title":"Muscle biopsy. A laboratory investigation","author":"Loughlin M","year":"1993"},{"key":"cit0062","volume-title":"Histotechnology","author":"Sheehan D","year":"1987","edition":"2"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.016"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00008.2019"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0209"}],"container-title":["Autophagy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15548627.2021.2016255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T12:24:09Z","timestamp":1664540649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15548627.2021.2016255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,29]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10,3]]}},"alternative-id":["10.1080\/15548627.2021.2016255"],"URL":"https:\/\/doi.org\/10.1080\/15548627.2021.2016255","relation":{},"ISSN":["1554-8627","1554-8635"],"issn-type":[{"value":"1554-8627","type":"print"},{"value":"1554-8635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,29]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kaup20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kaup20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}