{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:37:17Z","timestamp":1793637437191,"version":"4.5.1"},"reference-count":90,"publisher":"Informa UK Limited","issue":"1","funder":[{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jennifer Salvitti Davis Chair in Ophthalmology"},{"DOI":"10.13039\/100015166","name":"UPMC Enterprises","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Dr. Patricia Cayne and Mr. James Cayne"},{"name":"Wiegand Entrepreneurial Award"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Autophagy"],"published-print":{"date-parts":[[2023,1,2]]},"DOI":"10.1080\/15548627.2022.2062887","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T01:55:11Z","timestamp":1651024511000},"page":"92-111","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":202,"title":["Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD"],"prefix":"10.1080","volume":"19","author":[{"given":"Urvi","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayan","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-4976","authenticated-orcid":false,"given":"Callen T.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1856-0482","authenticated-orcid":false,"given":"Ying","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana Padmanabhan","family":"Nair","sequence":"additional","affiliation":[{"name":"GROW Laboratory, Narayana Nethralaya Foundation, Bengaluru, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meysam","family":"Yazdankhah","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Strizhakova","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3757-779X","authenticated-orcid":false,"given":"Haitao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Hose","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezda A.","family":"Stepicheva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir","family":"Nemani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Maddipatla","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1841-9777","authenticated-orcid":false,"given":"Rhonda","family":"Grebe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjula","family":"Das","sequence":"additional","affiliation":[{"name":"Molecular Immunology, Mazumdar Shaw Medical Foundation, Bengaluru, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira L.","family":"Lathrop","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-1153","authenticated-orcid":false,"given":"Jos\u00e9-Alain","family":"Sahel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Institut De La Vision, INSERM, CNRS, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"J. Samuel","family":"Zigler","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkasubhra","family":"Ghosh","sequence":"additional","affiliation":[{"name":"GROW Laboratory, Narayana Nethralaya Foundation, Bengaluru, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Sergeev","sequence":"additional","affiliation":[{"name":"National Eye Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Handa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudette M.","family":"St. Croix","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasish","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03423-8"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1038\/nri2921"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112002"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1159\/000494627"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1086\/650493"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.12.031"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0588-y"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12274"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42004"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124365"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12973"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.3109\/00365519509110257"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.03.007"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0655-7"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1002\/path.4870"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18993"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-020-00205-w"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142351"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2012.03.008"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2017.104"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2019.11.007"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12561"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.4161\/auto.27292"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.04.006"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25672"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0003-4"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1002\/0471140864.ps2809s79"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1002\/pro.674"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.09.037"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16018"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.49890"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.03.012"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1474314"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00142"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.08.015"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8490908"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.07.012"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.05.023"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11262-1"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.591803"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.657478"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6347"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-130081"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1021\/jp071439h"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2020.183318"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.309"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2014.09.010"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2020.3930"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18051089"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.11.3451"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-03-0268"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.176"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00524-z"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4450"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.3109\/03630260903346924"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2105465118"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1159\/000485089"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00553-6"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.698679"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-1999-1301"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2298-2"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2018-0741"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101328"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0724-6"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"cit0067","first-page":"348092","volume":"2013","author":"Whitcup SM","year":"2013","journal-title":"Int J Inflam"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03856-y"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42601"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0351-9"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.03.033"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2215"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.061"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03762-2"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153241"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.3390\/cells9091948"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21829-6"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.03.002"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00239"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3RI0615-239R"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02386-6"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.01.018"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4367"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-01763-5"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01706.x"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1871204"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00303-2"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109521"}],"container-title":["Autophagy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15548627.2022.2062887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T08:48:50Z","timestamp":1672130930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15548627.2022.2062887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,2]]}},"alternative-id":["10.1080\/15548627.2022.2062887"],"URL":"https:\/\/doi.org\/10.1080\/15548627.2022.2062887","relation":{},"ISSN":["1554-8627","1554-8635"],"issn-type":[{"value":"1554-8627","type":"print"},{"value":"1554-8635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kaup20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kaup20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}