{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:48:50Z","timestamp":1789951730075,"version":"4.0.1"},"reference-count":65,"publisher":"Informa UK Limited","issue":"4","funder":[{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","award":["R01 ES010807, P30 ES06096, T32 ES007250"],"award-info":[{"award-number":["R01 ES010807, P30 ES06096, T32 ES007250"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenetics"],"published-print":{"date-parts":[[2018,4,3]]},"DOI":"10.1080\/15592294.2018.1454243","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T16:36:55Z","timestamp":1521650215000},"page":"363-375","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":20,"title":["Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes"],"prefix":"10.1080","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2495-2324","authenticated-orcid":false,"given":"Andrew","family":"VonHandorf","sequence":"first","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"S\u00e1nchez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Biesiada","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-3102","authenticated-orcid":false,"given":"Mario","family":"Medvedovic","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1318-8909","authenticated-orcid":false,"given":"Alvaro","family":"Puga","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2018,5,3]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2006.05.022"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1111\/j.0272-4332.2004.00512.x"},{"key":"cit0003","author":"Wilbur S","year":"2012","journal-title":"Toxicological profile for chromium"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1080\/10408440500534032"},{"key":"cit0005","first-page":"1","author":"National Toxicology P","year":"2008","journal-title":"Natl Toxicol Program Tech Rep Ser"},{"key":"cit0006","first-page":"11","volume":"100","author":"IARC","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Hum."},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv070"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu206"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2015.05.004"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-015-0054-z"},{"key":"cit0011","first-page":"1","volume":"49","author":"IARC","year":"1990","journal-title":"IARC Monogr Eval Carcinog Risks Hum."},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940020508"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(87)90051-0"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112520"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.02110s5729"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1021\/tx049774+"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210560200"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh242"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1021\/tx900360w"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu175"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1515\/REVEH.2008.23.1.39"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.10.010"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2013.12.001"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000007271.53241.ae"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1021\/tx200251t"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800157"},{"key":"cit0027","first-page":"2045","volume":"56","author":"Kim G","year":"1996","journal-title":"Cancer Res."},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.9849"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.10.2401"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbaexp.2007.07.002"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00838-07"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310800200"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097849"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1101\/gr.142067.112"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.05.004"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.09.023"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2688"},{"key":"cit0038","first-page":"231","volume":"19","author":"Chen F","year":"2000","journal-title":"J Environ Pathol Toxicol Oncol."},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.33"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.024"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1101\/gr.201517.115"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3663"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.08.006"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2718"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.09.013"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.07.023"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3743"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.11"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.055"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"cit0051","unstructured":"http:\/\/broadinstitute.github.io\/picard\/."},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1101\/gr.3715005"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1101\/gr.097857.109"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1177"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw257"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1754"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbs017"},{"key":"cit0060","unstructured":"Hensley J, Albanus RD, Parker S. https:\/\/github.com\/ParkerLab\/atactk\/."},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1038\/nature11247"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1160"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1038\/nature13992"},{"key":"cit0065","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-98141-3","author":"Wickham H.","year":"2009","journal-title":"ggplot2: elegant graphics for data analysis"}],"container-title":["Epigenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15592294.2018.1454243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T04:27:41Z","timestamp":1598761661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15592294.2018.1454243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,3]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4,3]]}},"alternative-id":["10.1080\/15592294.2018.1454243"],"URL":"https:\/\/doi.org\/10.1080\/15592294.2018.1454243","relation":{},"ISSN":["1559-2294","1559-2308"],"issn-type":[{"value":"1559-2294","type":"print"},{"value":"1559-2308","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}