{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:17:06Z","timestamp":1789985826104,"version":"4.0.1"},"reference-count":61,"publisher":"Informa UK Limited","issue":"7","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MFE-146824"],"award-info":[{"award-number":["MFE-146824"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56NS076263"],"award-info":[{"award-number":["R56NS076263"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54HD079125"],"award-info":[{"award-number":["U54HD079125"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES021707"],"award-info":[{"award-number":["R01ES021707"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K01MH116389-01A1"],"award-info":[{"award-number":["1K01MH116389-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenetics"],"published-print":{"date-parts":[[2019,7,3]]},"DOI":"10.1080\/15592294.2019.1609867","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T02:49:43Z","timestamp":1555987783000},"page":"672-684","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":51,"title":["Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights"],"prefix":"10.1080","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-1335","authenticated-orcid":false,"given":"Benjamin I.","family":"Laufer","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, Genome Center, MIND Institute, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7918-728X","authenticated-orcid":false,"given":"Hyeyeon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, Genome Center, MIND Institute, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-3806","authenticated-orcid":false,"given":"Annie","family":"Vogel Ciernia","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, Genome Center, MIND Institute, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-3298","authenticated-orcid":false,"given":"Charles E.","family":"Mordaunt","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, Genome Center, MIND Institute, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3480-2031","authenticated-orcid":false,"given":"Janine M.","family":"LaSalle","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, Genome Center, MIND Institute, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20735"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23198"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0745"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.06.013"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.11.4997"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08092-3"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.154"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2016-0138"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(03)00035-1"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1448"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.042"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1038\/nature13200"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135555"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001212"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100715"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-503011"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-6-58"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32278"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003515"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0827-6"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2016.1192736"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw043"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.058"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1906"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1038\/nature14248"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1038\/nature12787"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071715-050738"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3124-15.2016"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.07.004"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.026"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00005"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-3-20"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1104832"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-9-r99"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.4161\/cam.4.3.11606"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1038\/nn1428"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.07.007"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1242\/dev.090621"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.166306"},{"key":"CIT0040","first-page":"403642","author":"Powers RK","year":"2018","journal-title":"bioRxiv"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.031013"},{"key":"CIT0042","first-page":"5","author":"Sullivan KD","year":"2016","journal-title":"Elife"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1038\/nature18626"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.03.021"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.262443999"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20447"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw723"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1038\/nature05987"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.218"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23886"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr167"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15931.2"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxy007"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-10-r83"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx183"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv145"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1630"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021800"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt343"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.05.004"}],"container-title":["Epigenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15592294.2019.1609867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T22:24:06Z","timestamp":1599258246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15592294.2019.1609867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,6]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7,3]]}},"alternative-id":["10.1080\/15592294.2019.1609867"],"URL":"https:\/\/doi.org\/10.1080\/15592294.2019.1609867","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/428482","asserted-by":"object"}]},"ISSN":["1559-2294","1559-2308"],"issn-type":[{"value":"1559-2294","type":"print"},{"value":"1559-2308","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}