{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:27:37Z","timestamp":1789986457417,"version":"4.0.1"},"reference-count":69,"publisher":"Informa UK Limited","issue":"4","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Diabetes UK under Grant"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenetics"],"published-print":{"date-parts":[[2022,4,3]]},"DOI":"10.1080\/15592294.2021.1908706","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T05:53:29Z","timestamp":1617170009000},"page":"405-421","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":16,"title":["DNA methylation signatures in cord blood associated with birthweight are enriched for dmCpGs previously associated with maternal hypertension or pre-eclampsia, smoking and folic acid intake"],"prefix":"10.1080","volume":"17","author":[{"given":"E","family":"Antoun","sequence":"first","affiliation":[{"name":"Human Development and health, Faculty of Medicine, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Titcombe","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Dalrymple","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NT","family":"Kitaba","sequence":"additional","affiliation":[{"name":"Human Development and health, Faculty of Medicine, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SJ","family":"Barton","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ac","family":"Flynn","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Murray","sequence":"additional","affiliation":[{"name":"Human Development and health, Faculty of Medicine, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ES","family":"Garratt","sequence":"additional","affiliation":[{"name":"Human Development and health, Faculty of Medicine, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PT","family":"Seed","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SL","family":"White","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Cooper","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK"},{"name":"NIHR, NIHR Southampton BiomedGical Research Centre, Southampton"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M","family":"Inskip","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6907-613X","authenticated-orcid":false,"given":"M","family":"Hanson","sequence":"additional","affiliation":[{"name":"Human Development and health, Faculty of Medicine, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Poston","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KM","family":"Godfrey","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK"},{"name":"NIHR, NIHR Southampton BiomedGical Research Centre, Southampton"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KA","family":"Lillycrop","sequence":"additional","affiliation":[{"name":"NIHR, NIHR Southampton BiomedGical Research Centre, Southampton"},{"name":"Biological Sciences, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"UPBEAT Consortium\/EpiGen Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"issue":"162","key":"cit0001","volume":"22","author":"Jaddoe VW","year":"2008","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"67","key":"cit0002","volume":"18","author":"Kataoka MC","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"issue":"391","key":"cit0003","volume":"88","author":"Brynhildsen J","year":"2009","journal-title":"Acta Obstet Gynecol Scand"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065017"},{"issue":"214365","key":"cit0005","volume":"2011","author":"Backes CH","year":"2011","journal-title":"J Pregnancy"},{"issue":"17","key":"cit0006","volume":"4","author":"Allen VM","year":"2004","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1255","key":"cit0007","volume":"121","author":"Sridhar SB","year":"2013","journal-title":"Obstet Gynecol"},{"key":"cit0008","volume":"11","author":"Amati F","journal-title":"Nutrients"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi137"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008870"},{"issue":"577","key":"cit0011","volume":"2","author":"Barker DJ","year":"1989","journal-title":"Lancet"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1136\/jech.58.2.120"},{"issue":"335","key":"cit0013","volume":"29","author":"Paltiel O","year":"2015","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"647","key":"cit0014","volume":"40","author":"Risnes KR","year":"2011","journal-title":"Int J Epidemiol"},{"issue":"49","key":"cit0015","volume":"4","author":"Lan X","year":"2013","journal-title":"Front Genet"},{"issue":"1382","key":"cit0016","volume":"135","author":"Lillycrop KA","year":"2005","journal-title":"J Nutr"},{"issue":"680","key":"cit0017","volume":"98","author":"Joubert BR","year":"2016","journal-title":"Am J Hum Genet"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.10.066"},{"issue":"98","key":"cit0019","volume":"43","author":"Howe CG","year":"2020","journal-title":"Diabetes Care"},{"issue":"127","key":"cit0020","volume":"132","author":"Kang J","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"issue":"4067","key":"cit0021","volume":"26","author":"Sharp GC","year":"2017","journal-title":"Hum Mol Genet"},{"issue":"41","key":"cit0022","volume":"8","author":"Geraghty AA","year":"2015","journal-title":"Nutr Metab Insights"},{"issue":"1893","key":"cit0023","volume":"10","author":"Kupers LK","year":"2019","journal-title":"Nat Commun"},{"issue":"288","key":"cit0024","volume":"98","author":"Bibikova M","year":"2011","journal-title":"Genomics"},{"issue":"22","key":"cit0025","volume":"16","author":"Lizio M","year":"2015","journal-title":"Genome Biol"},{"issue":"57","key":"cit0026","volume":"489","author":"Consortium EP","year":"2012","journal-title":"Nature"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00227-2"},{"key":"cit0028","volume-title":"in Weight Gain During Pregnancy: reexamining the Guidelines","author":"Rasmussen KM","year":"2009"},{"issue":"42","key":"cit0029","volume":"35","author":"Inskip HM","year":"2006","journal-title":"Int J Epidemiol"},{"issue":"7","key":"cit0030","volume":"4","author":"Chang CC","year":"2015","journal-title":"Gigascience"},{"issue":"39313","key":"cit0031","volume":"6","author":"Chou WC","year":"2016","journal-title":"Sci Rep"},{"issue":"68","key":"cit0032","volume":"526","author":"Genomes Project C","year":"2015","journal-title":"Nature"},{"issue":"811","key":"cit0033","volume":"48","author":"Loh PR","year":"2016","journal-title":"Nat Genet"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3643"},{"issue":"299","key":"cit0035","volume":"17","author":"Pan H","year":"2016","journal-title":"BMC Bioinformatics"},{"issue":"1363","key":"cit0036","volume":"30","author":"Aryee MJ","year":"2014","journal-title":"Bioinformatics"},{"issue":"208","key":"cit0037","volume":"17","author":"Pidsley R","year":"2016","journal-title":"Genome Biol"},{"issue":"882","key":"cit0038","volume":"28","author":"Leek JT","year":"2012","journal-title":"Bioinformatics"},{"issue":"19","key":"cit0039","volume":"18","author":"Van Iterson M","year":"2017","journal-title":"Genome Biol"},{"issue":"86","key":"cit0040","volume":"13","author":"Houseman EA","year":"2012","journal-title":"BMC Bioinformatics"},{"issue":"354","key":"cit0041","volume":"11","author":"Bakulski KM","year":"2016","journal-title":"Epigenetics"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222458"},{"issue":"170","key":"cit0045","volume":"1","author":"Leddy MA","year":"2008","journal-title":"Rev Obstet Gynecol"},{"issue":"984","key":"cit0046","volume":"376","author":"Ludwig DS","year":"2010","journal-title":"Lancet"},{"issue":"221","key":"cit0047","volume":"17","author":"Cantarutti A","year":"2017","journal-title":"BMC Pregnancy Childbirth"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1007\/s13524-012-0148-2"},{"issue":"286","key":"cit0049","volume":"32","author":"Phipson B","year":"2016","journal-title":"Bioinformatics"},{"issue":"131","key":"cit0050","volume":"49","author":"Bonder MJ","year":"2017","journal-title":"Nat Genet"},{"issue":"10577","key":"cit0051","volume":"7","author":"Joubert BR","year":"2016","journal-title":"Nat Commun"},{"issue":"375","key":"cit0052","volume":"74","author":"Kazmi N","year":"2019","journal-title":"Hypertension"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1159\/000093328"},{"issue":"2","key":"cit0054","volume":"19","author":"Van Baak TE","year":"2018","journal-title":"Genome Biol"},{"issue":"61","key":"cit0055","volume":"17","author":"Gaunt TR","year":"2016","journal-title":"Genome Biol"},{"issue":"2762","key":"cit0056","volume":"21","author":"Han L","year":"2012","journal-title":"Stem Cells Dev"},{"issue":"157","key":"cit0057","volume":"8","author":"Harris RA","year":"2013","journal-title":"Epigenetics"},{"issue":"1035","key":"cit0058","volume":"5","author":"Su L","year":"2010","journal-title":"ACS Chem Biol"},{"issue":"15121","key":"cit0059","volume":"5","author":"Ma H","year":"2015","journal-title":"Sci Rep"},{"issue":"3982","key":"cit0060","volume":"126","author":"Feng X","year":"2013","journal-title":"J Cell Sci"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.070"},{"key":"cit0062","doi-asserted-by":"crossref","DOI":"10.1006\/geno.1999.5751","volume":"57","author":"Heinemann T","year":"1999","journal-title":"Genomics"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043931"},{"issue":"1027","key":"cit0064","volume":"94","author":"Hanson MA","year":"2014","journal-title":"Physiol Rev"},{"issue":"61627","key":"cit0065","volume":"8","author":"Yu Z","year":"2013","journal-title":"PLoS One"},{"key":"cit0066","author":"Reilly JJ","year":"2005","journal-title":"BMJ"},{"key":"cit0067","volume":"1","author":"Stevens DR","year":"2020","journal-title":"J Dev Orig Health Dis"},{"issue":"570","key":"cit0068","volume":"10","author":"Adane AA","year":"2019","journal-title":"J Dev Orig Health Dis"},{"key":"cit0069","author":"Lin X","journal-title":"BMC Med"}],"container-title":["Epigenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15592294.2021.1908706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T09:37:32Z","timestamp":1649237852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15592294.2021.1908706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,28]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4,3]]}},"alternative-id":["10.1080\/15592294.2021.1908706"],"URL":"https:\/\/doi.org\/10.1080\/15592294.2021.1908706","relation":{},"ISSN":["1559-2294","1559-2308"],"issn-type":[{"value":"1559-2294","type":"print"},{"value":"1559-2308","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}