{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:50:49Z","timestamp":1761742249223},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000971","name":"Diabetes Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>Chemically\u2010induced diabetic mice and spontaneously\ndiabetic NOD mice have been valuable\nas recipients for experimental islet transplantation.\nHowever, their maintenance often\nrequires parenteral insulin. Diabetogenic chemicals\ncan be cytotoxic to the host\u2019s immune system\nand to other organs some of which are\noften used as the transplant site. Procurement\nof diabetic cohorts in the NOD mouse is problematic\ndue to variability in the age of disease\nonset. We show that RIP\u2010K<jats:sup>b<\/jats:sup> mice, which spontaneously\ndevelop non\u2010immune diabetes due to\nover\u2010expression of the H\u20102K<jats:sup>b<\/jats:sup> heavy chain in\nbeta cells, offer many advantages as islet transplant\nrecipients. Diabetes is predictable with a\nrelatively narrow range of onset (4 wk) and\nblood glucose levels (23.0\u00b1 4.0 mmol\/l for 39\nmales at 6 weeks of age). The diabetes is mild enough so that most diabetic mice can be maintained\nto 40 weeks of age without parenteral\ninsulin. This consistency of diabetes avails that\noutcomes of intervention can be interpreted\nwith confidence.<\/jats:p>","DOI":"10.1080\/15604280212530","type":"journal-article","created":{"date-parts":[[2003,11,11]],"date-time":"2003-11-11T16:00:48Z","timestamp":1068566448000},"page":"37-45","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Non\u2010Immune RIP\u2010k<sup>b<\/sup> Mouse is a Useful Host for Islet Transplantation, as the Diabetes is Spontaneous, Mild and Predictable"],"prefix":"10.1155","volume":"3","author":[{"given":"Robyn M.","family":"Sutherland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne N.","family":"Mountford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janette","family":"Allison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard C.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Lew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,15]]},"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2002\/408504.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/15604280212530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T23:05:21Z","timestamp":1723071921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/15604280212530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,15]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1080\/15604280212530"],"URL":"https:\/\/doi.org\/10.1080\/15604280212530","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"type":"print","value":"2314-6745"},{"type":"electronic","value":"2314-6753"}],"subject":[],"published":{"date-parts":[[2001,10,15]]},"assertion":[{"value":"2001-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}