{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:19:38Z","timestamp":1770502778793,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>The role of the antioxidant defense mechanism in diabetesinduced\nanomalies was studied in the Cohen diabetes\u2010sensitive\n(CDs) and \u2010resistant (CDr) rats, a genetic model of nutritionally\ninduced type 2 diabetes mellitus. Embryos, 12.5\u2010day\u2010old, of CDs\nand CDr rats fed regular diet (RD) or a diabetogenic high\u2010sucrose\ndiet (HSD) were monitored for growth retardation and congenital\nanomalies. Activity of superoxide dismutase (SOD) and catalaselike\nenzymes and levels of ascorbic acid (AA), uric acid (UA), and\ndehydroascorbic acid (DHAA) were measured in embryonic homogenates.\nWhen fed RD, CDs rats had a decreased rate of pregnancy,\nand an increased embryonic resorption. CDs embryos were\nsmaller than CDr embryos; 46% were maldeveloped and 7% exhibited\nneural tube defects (NTDs). When fed HSD, rate of pregnancy\nwas reduced, resorption rate was greatly increased (56%;\n<jats:italic>P<\/jats:italic> &lt; .001), 47.6% of the embryos were retrieved without heart\nbeats, and 27% exhibited NTD. In contrast, all the CDr embryos\nwere normal when fed RD or HSD. Activity of SOD and catalase\nwas not different in embryos of CDs and CDr rats fedRD. When fed\nHSD, levels of AA were significantly reduced, the ratio DHAA\/AA\nwas significantly increased, and SOD activity was not sufficiently\nincreased when compared to embryos of CDr. The reduced fertility\nof the CDs rats, the growth retardation, and NTD seem to be\ngenetically determined. Maternal hyperglycemia seems to result in environmentally induced embryonic oxidative stress, resulting in\nfurther embryonic damage.<\/jats:p>","DOI":"10.1080\/15604280214933","type":"journal-article","created":{"date-parts":[[2003,11,11]],"date-time":"2003-11-11T16:00:48Z","timestamp":1068566448000},"page":"247-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Role of Reactive Oxygen Species in Diabetes\u2010Induced Anomalies in Embryos of Cohen Diabetic Rats"],"prefix":"10.1155","volume":"3","author":[{"given":"Sarah W.","family":"Zangen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirhiya","family":"Yaffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Shechtman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Zangen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asher","family":"Ornoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,7,22]]},"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2002\/802764.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/15604280214933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T09:26:44Z","timestamp":1723109204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/15604280214933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1080\/15604280214933"],"URL":"https:\/\/doi.org\/10.1080\/15604280214933","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"2002-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}