{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:03:00Z","timestamp":1790812980004,"version":"4.1.0"},"reference-count":57,"publisher":"Informa UK Limited","issue":"8","funder":[{"DOI":"10.13039\/100002806","name":"Discovery Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002806","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001322","name":"Medical Research Council South Africa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Research Foundation South Africa"},{"name":"CIDRI Clinical Fellowship"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["204755\/2\/16\/z"],"award-info":[{"award-number":["204755\/2\/16\/z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health","doi-asserted-by":"crossref","award":["R21HD085849"],"award-info":[{"award-number":["R21HD085849"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fogarty International Centre"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HU 2731\/1-1"],"award-info":[{"award-number":["HU 2731\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"HERCULES Centre","award":["P30ES019776"],"award-info":[{"award-number":["P30ES019776"]}]},{"name":"NIH","award":["GM117946"],"award-info":[{"award-number":["GM117946"]}]},{"name":"Claude Leon Fellowship"},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203525\/Z\/16\/Z"],"award-info":[{"award-number":["203525\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ABMRF young investigator grant","award":["24467"],"award-info":[{"award-number":["24467"]}]},{"name":"NIH","award":["R21AA023887"],"award-info":[{"award-number":["R21AA023887"]}]},{"DOI":"10.13039\/501100004513","name":"Harry Crossley Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004513","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["The World Journal of Biological Psychiatry"],"published-print":{"date-parts":[[2022,9,14]]},"DOI":"10.1080\/15622975.2021.2016955","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T05:13:14Z","timestamp":1639372394000},"page":"601-612","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":19,"title":["Newborn differential DNA methylation and subcortical brain volumes as early signs of severe neurodevelopmental delay in a South African Birth Cohort Study"],"prefix":"10.1080","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6005-417X","authenticated-orcid":false,"given":"Anke","family":"H\u00fcls","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4887-1644","authenticated-orcid":false,"given":"Catherine J.","family":"Wedderburn","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Red Cross War Memorial Children\u2019s Hospital, University of Cape Town, Cape Town, South Africa"},{"name":"Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK"},{"name":"Neuroscience Institute, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nynke A.","family":"Groenewold","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Red Cross War Memorial Children\u2019s Hospital, University of Cape Town, Cape Town, South Africa"},{"name":"Neuroscience Institute, University of Cape Town, Cape Town, South Africa"},{"name":"Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa"},{"name":"South African Medical Research Council (SAMRC) Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Gladish","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of British Columbia, Vancouver, Canada"},{"name":"BC Children\u2019s Hospital Research Institute, Vancouver, Canada"},{"name":"Centre for Molecular Medicine and Therapeutics, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1593-997X","authenticated-orcid":false,"given":"Meaghan J.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, University of Manitoba, and Children\u2019s Hospital Research Institute of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastassja","family":"Koen","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, University of Cape Town, Cape Town, South Africa"},{"name":"Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa"},{"name":"South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia L.","family":"MacIsaac","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of British Columbia, Vancouver, Canada"},{"name":"BC Children\u2019s Hospital Research Institute, Vancouver, Canada"},{"name":"Centre for Molecular Medicine and Therapeutics, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-9446","authenticated-orcid":false,"given":"David T. S.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of British Columbia, Vancouver, Canada"},{"name":"BC Children\u2019s Hospital Research Institute, Vancouver, Canada"},{"name":"Centre for Molecular Medicine and Therapeutics, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia E.","family":"Ramadori","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of British Columbia, Vancouver, Canada"},{"name":"BC Children\u2019s Hospital Research Institute, Vancouver, Canada"},{"name":"Centre for Molecular Medicine and Therapeutics, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-9660","authenticated-orcid":false,"given":"Kirsten A.","family":"Donald","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Red Cross War Memorial Children\u2019s Hospital, University of Cape Town, Cape Town, South Africa"},{"name":"Neuroscience Institute, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Kobor","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of British Columbia, Vancouver, Canada"},{"name":"BC Children\u2019s Hospital Research Institute, Vancouver, Canada"},{"name":"Centre for Molecular Medicine and Therapeutics, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Zar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Red Cross War Memorial Children\u2019s Hospital, University of Cape Town, Cape Town, South Africa"},{"name":"South African Medical Research Council (SAMRC) Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan J.","family":"Stein","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, University of Cape Town, Cape Town, South Africa"},{"name":"Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa"},{"name":"South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu049"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1631760"},{"key":"CIT0003","doi-asserted-by":"crossref","unstructured":"Bayley N. 2006. Bayley scales of infant and toddler development. San Antonio (TX): Harcourt Assessment Inc.","DOI":"10.1037\/t14978-000"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31389-7"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31390-3"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1740"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31701-9"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31659-2"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3656"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2012.10.007"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-015-9771-0"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2018-000282"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002920"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0503-2"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4006.1272"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0717-y"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2018.1"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr327"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmaa108"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.08.015"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.08.044"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1037\/a0020761"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1611-2"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3479-08.2008"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-013-0511-x"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-015-0568-2"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1316"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00785-8"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-017-0370-2"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.19"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.05.001"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1144\/GSL.SP.2006.264.01.01"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.05.015"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-8-6"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv560"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2005.05.007"},{"key":"CIT0038","unstructured":"R Core Team. 2018. R: A language and environment for statistical computing. https:\/\/www.r-project.org\/."},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.7196\/sajch.547"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14148"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt237"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.05.020"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-016-1510-0"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1297-04.2004"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018746"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22487"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1037\/a0035893"},{"issue":"1","key":"CIT0050","first-page":"36","volume":"96","author":"Vitrikas K","year":"2017","journal-title":"Am Fam Physician"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.071"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12740"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.85"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.04.012"},{"key":"CIT0055","unstructured":"Wang J, Zhao Q. 2019. cate: High dimensional factor analysis and confounder adjusted testing. Available from: https:\/\/cran.r-project.org\/package=cate."},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116846"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206242"}],"container-title":["The World Journal of Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15622975.2021.2016955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T19:00:53Z","timestamp":1669575653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15622975.2021.2016955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,12]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,9,14]]}},"alternative-id":["10.1080\/15622975.2021.2016955"],"URL":"https:\/\/doi.org\/10.1080\/15622975.2021.2016955","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.03.13.20035501","asserted-by":"object"}]},"ISSN":["1562-2975","1814-1412"],"issn-type":[{"value":"1562-2975","type":"print"},{"value":"1814-1412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,12]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iwbp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iwbp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}