{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:42:34Z","timestamp":1793727754913,"version":"4.6.1"},"reference-count":40,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Science and Technology Bureau","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong Province Outstanding Youth Award"},{"name":"Three Million for Three Years Project of SYSMH"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Hematology"],"published-print":{"date-parts":[[2023,12,31]]},"DOI":"10.1080\/16078454.2023.2219554","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T07:36:04Z","timestamp":1686209764000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":9,"title":["Aberrant expression of T cell activation markers and upregulation of Tregs in bone marrow and peripheral blood in acute myeloid leukemia patients"],"prefix":"10.1080","volume":"28","author":[{"given":"Junyue","family":"Fang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Cellular and Molecular Diagnostics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghua","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezhi","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Department of Hematology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phei Er","family":"Saw","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69780-8"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2018.08.001"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2017.03.004"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00213"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-2153-5"},{"key":"e_1_3_2_7_1","doi-asserted-by":"crossref","unstructured":"Lamble AJ Kosaka Y Laderas T et al. Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia. Proc Natl Acad Sci U S A. 2020;117(25):14331\u201314341.","DOI":"10.1073\/pnas.1916206117"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-365817"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1428"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2006.10.008"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-277939"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-3010"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25791"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-208181"},{"key":"e_1_3_2_15_1","doi-asserted-by":"crossref","unstructured":"Xu Y Mou J Wang Y et al. Regulatory T cells promote the stemness of leukemia stem cells through IL10 cytokine-related signaling pathway. Leukemia. 2022;36(2):403\u2013415.","DOI":"10.1038\/s41375-021-01375-2"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400977"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.02.009"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.036"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2014.958464"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.05.010"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3850"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05380.x"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.178"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2004.07.006"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-740944"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-687749"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009499"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(97)00152-5"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2018.08.058"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900646"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143352"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.06.003"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.686156"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.1930391"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-206946"},{"key":"e_1_3_2_37_1","doi-asserted-by":"crossref","unstructured":"Ohue Y Nishikawa H. Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?. Cancer Sci. 2019;110(7):2080\u20132089.","DOI":"10.1111\/cas.14069"},{"key":"e_1_3_2_38_1","doi-asserted-by":"crossref","unstructured":"Williams P Basu S Garcia-Manero G et al. The distribution of T-cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia. 2019;125(9):1470\u20131481.","DOI":"10.1002\/cncr.31896"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0069-4"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-730614"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120974"}],"container-title":["Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/16078454.2023.2219554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T07:01:43Z","timestamp":1702278103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/16078454.2023.2219554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,8]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,12,31]]}},"alternative-id":["10.1080\/16078454.2023.2219554"],"URL":"https:\/\/doi.org\/10.1080\/16078454.2023.2219554","relation":{},"ISSN":["1607-8454"],"issn-type":[{"value":"1607-8454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,8]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=yhem20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=yhem20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2219554"}}