{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:19:54Z","timestamp":1791181194502,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: To compare the diagnostic utility of laboratory variables, \n            including matrix metalloproteinase\u20103 (MMP\u20103), anti\u2010cyclic citrullinated peptide \n            (CCP) antibodies, rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), \n            and C\u2010reactive protein (CRP) in \n            patients with erosive and non\u2010erosive rheumatoid arthritis (RA).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: We assembled a training set, consisting of 60 patients with RA, \n            all fulfilling the revised criteria of the American College of Rheumatology. A \n            commercial enzyme linked immunosorbent assay (ELISA) was used both to \n            test for anti\u2010CCP antibodies (second generation ELISA kit) and MMP; RF were \n            detected by latex\u2010enhanced immunonephelometric assay. CRP \n            was measured by latex turbidimetric immunoassay.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: The levels of anti\u2010CCP antibody titers and ESR were significantly \n            higher in patients with erosive disease than those in non\u2010erosive RA patients \n            (<jats:italic>p<\/jats:italic> &lt; 0.001 and 0.0341) respectively. Moreover, a higher frequency of elevated\n             titers of anti\u2010CCP antibodies was found in RA patients with erosions compared \n             to patients with non\u2010erosive RA (78.3% vs. 43.2% respectively). The ROC curves \n             of anti\u2010CCP passed closer to the upper left corner than those other markers and \n             area under the curve (AUC) of anti\u2010CCP was significantly larger than AUC of other \n             markers (0.755 for anti\u2010CCP, \n            0.660 for ESR, 0.611 for CRP, 0.577 for RF, and 0.484 for MMP\u20103 female).<\/jats:p><jats:p>A positive predictive value was higher for anti\u2010CCP antibodies in comparison to \n            other markers. We did not find significant statistical correlation between anti\u2010CCP \n            antibody titers and inflammatory markers such as ESR or CRP. However, we \n            confirmed the correlation of elevated titers of anti\u2010CCP antibodies and RF in both \n            groups of patients whereas \n            the degree of correlation was more significant in non\u2010erosive patients.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: The results of our study suggest that the presence of elevated \n            anti\u2010CCP antibody titers have better diagnostic\n             performance than MMP\u20103, RF, CRP and ESR in patients with erosive RA.<\/jats:p>","DOI":"10.1080\/17402520500233510","type":"journal-article","created":{"date-parts":[[2005,9,23]],"date-time":"2005-09-23T18:49:20Z","timestamp":1127501360000},"page":"197-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The Diagnostic Utility of Anti\u2010cyclic Citrullinated Peptide Antibodies, Matrix Metalloproteinase\u20103, Rheumatoid Factor, Erythrocyte Sedimentation Rate, and C\u2010reactive Protein in Patients with Erosive and Non\u2010erosive Rheumatoid Arthritis"],"prefix":"10.1155","volume":"12","author":[{"given":"O.","family":"Shovman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gilburd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zandman-Goddard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Sherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Orbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gerli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Shoenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2005\/949878.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/17402520500233510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:29:03Z","timestamp":1723116543000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/17402520500233510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1080\/17402520500233510"],"URL":"https:\/\/doi.org\/10.1080\/17402520500233510","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2005-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}