{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:01:32Z","timestamp":1765609292891},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>Previous studies on primary biliary cirrhosis (PBC) have focused on\n             the role of T lymphocytes as potential effectors of tissue injury. We hypothesized \n             that single nucleotide polymorphisms (SNPs) of genes involved in lymphocyte \n             proliferation would be responsible for uncontrolled expansion of T cells and \n             autoreactivity. To address this, we genotyped DNA from 154 patients with PBC \n             and 166 ethnically matched healthy controls for SNPs of five candidate genes \n             (60G\/A CTLA\u20104, 1858 C\/T LYP, \u2010IVS9 C\/T foxp3, p1323 C\/G ICOS and \u20109606 T\/C \n             CD25) using a TaqMan assay.<\/jats:p><jats:p>We report herein a statistically significant decrease in homozygosity rate\n              for the 60A\u22c6CTLA\u20104 allele in patients with PBC compared to controls (<jats:italic>p<\/jats:italic> = 0.0411). \n              Moreover, we found a significant association of the same allele and of the LYP\u22c6T \n              allele with anti\u2010mitochondrial antibody (AMA) serum negativity (<jats:italic>p<\/jats:italic> = 0.0304 and \n              0.0094, respectively). No association between any of the other studied SNPs and \n              PBC susceptibility, progression, or AMA status was observed. In conclusion, given \n              the high prevalence of SNPs in CTLA\u20104 detected in numerous autoimmune \n              diseases, we encourage a more detailed genetic analysis of this candidate gene. \n              Further, although obtained from a limited number of AMA\u2010negative subjects, our \n              data suggest a potential genetic \n             heterogeneity for this specific subgroup of patients with PBC.<\/jats:p>","DOI":"10.1080\/17402520500317859","type":"journal-article","created":{"date-parts":[[2005,12,28]],"date-time":"2005-12-28T15:17:00Z","timestamp":1135783020000},"page":"259-263","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["SNP Analysis of Genes Implicated in T Cell Proliferation in Primary Biliary Cirrhosis"],"prefix":"10.1155","volume":"12","author":[{"given":"Sabine","family":"Oertelt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Selmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Invernizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Podda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2005\/297598.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/17402520500317859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:42:58Z","timestamp":1723117378000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/17402520500317859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1080\/17402520500317859"],"URL":"https:\/\/doi.org\/10.1080\/17402520500317859","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2005-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}