{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:16:32Z","timestamp":1780373792585,"version":"3.54.1"},"reference-count":176,"publisher":"Informa UK Limited","issue":"4","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Delivery"],"published-print":{"date-parts":[[2021,4,3]]},"DOI":"10.1080\/17425247.2021.1853701","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T19:41:34Z","timestamp":1605901294000},"page":"471-487","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["The advantages of nanomedicine in the treatment of visceral leishmaniasis: between sound arguments and wishful thinking"],"prefix":"10.1080","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-3184","authenticated-orcid":false,"given":"Kevin","family":"Matha","sequence":"first","affiliation":[{"name":"MINT, Univ Angers, INSERM 1066, CNRS 6021, Universit\u00e9 Bretagne Loire, 4 Rue Larrey 49933 Angers cedex 9","place":["France"]},{"name":"4 rue Larrey, 49933 Angers cedex 9","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Calvignac","sequence":"additional","affiliation":[{"name":"MINT, Univ Angers, INSERM 1066, CNRS 6021, Universit\u00e9 Bretagne Loire, 4 Rue Larrey 49933 Angers cedex 9","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Gangneux","sequence":"additional","affiliation":[{"name":"(Institut de recherche en sant\u00e9, environnement et travail) - UMR_S 1085","place":["F-35000 Rennes, France"]},{"name":"Laboratoire de Parasitologie-Mycologie, CHU de Rennes, 2 rue Henri Le Guilloux, 35033","place":["Rennes, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Benoit","sequence":"additional","affiliation":[{"name":"MINT, Univ Angers, INSERM 1066, CNRS 6021, Universit\u00e9 Bretagne Loire, 4 Rue Larrey 49933 Angers cedex 9","place":["France"]},{"name":"4 rue Larrey, 49933 Angers cedex 9","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31204-2"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9554.1000388"},{"key":"e_1_3_7_5_1","unstructured":"WHO Expert Committee on the Control of the Leishmaniases\u00a0&\u00a0World Health Organization. Control of the leishmaniases: report of a meeting of the WHO Expert Commitee on the Control of Leishmaniases Geneva 22-26 March 2010.\u00a0World Health Organization; 2010.\u00a0https:\/\/apps.who.int\/iris\/handle\/10665\/44412 (Accessed 09 August 2020)"},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005100"},{"key":"e_1_3_7_7_1","first-page":"147","article-title":"Epidemiology of visceral leishmaniasis, Clin","volume":"6","author":"Ready PD","year":"2014","unstructured":"Ready PD. Epidemiology of visceral leishmaniasis, Clin. Epidemiol. 2014;6:147\u2013154.","journal-title":"Epidemiol"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.5.7.805"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.07.016"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9872095"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2006.09.004"},{"key":"e_1_3_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.913-916.2001"},{"key":"e_1_3_7_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102351200"},{"key":"e_1_3_7_14_1","doi-asserted-by":"crossref","unstructured":"Ponte-sucre A Gamarro F Dujardin J et al. Drug resistance and treatment failure in leishmaniasis\u202f: A 21st century challenge. PLOS Neglected Tropical Diseases. 2017;11(12):e0006052.","DOI":"10.1371\/journal.pntd.0006052"},{"key":"e_1_3_7_15_1","unstructured":"WHO Bi-Regional consultation on the status of leishmaniasis control and surveillance in East Africa. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO. (Accessed 01 Sept 2020)."},{"key":"e_1_3_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01129-16"},{"key":"e_1_3_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-016-0112-2"},{"key":"e_1_3_7_18_1","first-page":"609","article-title":"A randomized clinical trial of low dosage combination of pentamidine and allopurinol in the treatment of antimony unresponsive cases of visceral leishmaniasis","volume":"49","author":"Das VN","year":"2001","unstructured":"Das VN, Ranjan A, Sinha AN, et al. A randomized clinical trial of low dosage combination of pentamidine and allopurinol in the treatment of antimony unresponsive cases of visceral leishmaniasis. J Assoc Physicians India. 2001;49:609\u2013613. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11584934.","journal-title":"J Assoc Physicians India"},{"key":"e_1_3_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(83)90058-5"},{"key":"e_1_3_7_20_1","first-page":"314","article-title":"Changing response to diamidine compounds in cases of kala-azar unresponsive to antimonial","volume":"39","author":"Jha SN","year":"1991","unstructured":"Jha SN, Singh NK, Jha TK. Changing response to diamidine compounds in cases of kala-azar unresponsive to antimonial. J Assoc Physicians India. 1991;39:314\u2013316. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1938817.","journal-title":"J Assoc Physicians India"},{"key":"e_1_3_7_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.62887"},{"key":"e_1_3_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(03)00162-2"},{"key":"e_1_3_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.12.043"},{"key":"e_1_3_7_24_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.4.2.177"},{"key":"e_1_3_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001674"},{"key":"e_1_3_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12996"},{"key":"e_1_3_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101664"},{"key":"e_1_3_7_28_1","unstructured":"Clinicaltrials.gov. https:\/\/clinicaltrials.gov\/ct2\/results?cond=Visceral+Leishmaniasis&term=&cntry=&state=&city=&dist=. (Accessed 01 Sept 2020)."},{"key":"e_1_3_7_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00499"},{"key":"e_1_3_7_30_1","first-page":"388","article-title":"Around the world in a month, Nat","volume":"38","author":"Julien-en-Genevois F","year":"2020","unstructured":"Julien-en-Genevois F, Dolgin E. Around the world in a month, Nat. Biotechnol. 2020;38:388.","journal-title":"Biotechnol"},{"key":"e_1_3_7_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs15327k"},{"key":"e_1_3_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(97)00048-3"},{"key":"e_1_3_7_33_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2018-0448"},{"key":"e_1_3_7_34_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.19-0179"},{"key":"e_1_3_7_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S140363"},{"key":"e_1_3_7_36_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-9199-jvatitd-1441-18"},{"key":"e_1_3_7_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano9121749"},{"key":"e_1_3_7_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0358"},{"key":"e_1_3_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.09.098"},{"key":"e_1_3_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1340"},{"key":"e_1_3_7_41_1","first-page":"1900133","article-title":"Immunotoxicity Considerations for Next Generation Cancer Nanomedicines","volume":"6","author":"Hannon G","year":"2019","unstructured":"Hannon G, Lysaght J, Liptrott NJ, et al. Immunotoxicity Considerations for Next Generation Cancer Nanomedicines. Adv Sci (Weinheim, Baden-Wurttemberg, Ger. 2019;6:1900133.","journal-title":"Adv Sci (Weinheim, Baden-Wurttemberg, Ger"},{"key":"e_1_3_7_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V55.1.156.156"},{"key":"e_1_3_7_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2014.00108"},{"key":"e_1_3_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.10.010"},{"key":"e_1_3_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.04.043"},{"key":"e_1_3_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.02.145"},{"key":"e_1_3_7_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.9.2327-2332.2000"},{"key":"e_1_3_7_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00315-06"},{"key":"e_1_3_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0538-7"},{"key":"e_1_3_7_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.9.1954"},{"key":"e_1_3_7_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.834-840.2002"},{"key":"e_1_3_7_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz076"},{"key":"e_1_3_7_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp140"},{"key":"e_1_3_7_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.828-833.2002"},{"key":"e_1_3_7_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.9.2391"},{"key":"e_1_3_7_56_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.19-0568"},{"key":"e_1_3_7_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903627"},{"key":"e_1_3_7_58_1","first-page":"75","article-title":"Liposomal amphotericin B (AmBisome) in Mediterranean visceral leishmaniasis: a multi-centre trial","volume":"87","author":"Davidson RN","year":"1994","unstructured":"Davidson RN, Di Martino L, Gradoni L, et al. Liposomal amphotericin B (AmBisome) in Mediterranean visceral leishmaniasis: a multi-centre trial. Q J Med. 1994;87:75\u201381. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8153291.","journal-title":"Q J Med"},{"key":"e_1_3_7_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002613"},{"key":"e_1_3_7_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.suppl_1.37"},{"key":"e_1_3_7_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra054415"},{"key":"e_1_3_7_62_1","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_3_7_63_1","doi-asserted-by":"publisher","DOI":"10.1086\/313498"},{"key":"e_1_3_7_64_1","doi-asserted-by":"publisher","DOI":"10.1086\/514672"},{"key":"e_1_3_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(98)70046-0"},{"key":"e_1_3_7_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903113401004"},{"key":"e_1_3_7_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt055"},{"key":"e_1_3_7_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz064"},{"key":"e_1_3_7_69_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306137200"},{"key":"e_1_3_7_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1995.tb00020.x"},{"key":"e_1_3_7_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv111"},{"key":"e_1_3_7_72_1","first-page":"176","article-title":"Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome, Nanomedicine Nanotechnology, Biol","volume":"8","author":"Szebeni J","year":"2012","unstructured":"Szebeni J, Bedocs P, Rozsnyay Z, et al. Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome, Nanomedicine Nanotechnology, Biol. Med. 2012;8:176\u2013184.","journal-title":"Med"},{"key":"e_1_3_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.06.017"},{"key":"e_1_3_7_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/28.suppl_B.49"},{"key":"e_1_3_7_75_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018997730462"},{"key":"e_1_3_7_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp196"},{"key":"e_1_3_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.09.016"},{"key":"e_1_3_7_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-018-0461-0"},{"key":"e_1_3_7_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.269"},{"key":"e_1_3_7_80_1","first-page":"21","article-title":"Toxicity of some charged lipids used in liposome preparations","volume":"37","author":"Campbell PI","year":"1983","unstructured":"Campbell PI. Toxicity of some charged lipids used in liposome preparations. Cytobios. 1983;37:21\u201326. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6851664.","journal-title":"Cytobios"},{"key":"e_1_3_7_81_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2013.751370"},{"key":"e_1_3_7_82_1","doi-asserted-by":"publisher","DOI":"10.4236\/ajac.2013.47A014"},{"key":"e_1_3_7_83_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.891271"},{"key":"e_1_3_7_84_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.14.182"},{"key":"e_1_3_7_85_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S55678"},{"key":"e_1_3_7_86_1","first-page":"2663","article-title":"Overexpressed macrophage mannose receptor targeted nanocapsules- mediated cargo delivery approach for eradication of resident parasite: in vitro and in vivo studies","volume":"32","author":"Asthana S","year":"2015","unstructured":"Asthana S, Gupta PK, Jaiswal AK, et al. Overexpressed macrophage mannose receptor targeted nanocapsules- mediated cargo delivery approach for eradication of resident parasite: in vitro and in vivo studies. Pharm Res. 2015;32:2663\u20132677.","journal-title":"Pharm Res"},{"key":"e_1_3_7_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks286"},{"key":"e_1_3_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.12.143"},{"key":"e_1_3_7_89_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S106548"},{"key":"e_1_3_7_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02343-12"},{"key":"e_1_3_7_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.09.049"},{"key":"e_1_3_7_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.237"},{"key":"e_1_3_7_93_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.10.23"},{"key":"e_1_3_7_94_1","doi-asserted-by":"publisher","DOI":"10.1080\/10611860290007513"},{"key":"e_1_3_7_95_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007051413280"},{"key":"e_1_3_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.09.063"},{"issue":"48","key":"e_1_3_7_97_1","doi-asserted-by":"crossref","first-page":"15170","DOI":"10.1002\/anie.201709002","article-title":"Editorial: drug Delivery: too Much Complexity, Not Enough Reproducibility?","volume":"56","author":"Leroux JC","year":"2017","unstructured":"Leroux JC. Editorial: drug Delivery: too Much Complexity, Not Enough Reproducibility? Angew Chem Int Educ. 2017;56(48):15170\u201315171.","journal-title":"Angew Chem Int Educ"},{"key":"e_1_3_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.03.032"},{"key":"e_1_3_7_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2016.08.002"},{"key":"e_1_3_7_100_1","first-page":"1","article-title":"Why miltefosine - A life-saving drug for leishmaniasis-is unavailable to people who need it the most","volume":"3","author":"Sunyoto T","year":"2018","unstructured":"Sunyoto T, Potet J, Boelaert M. Why miltefosine - A life-saving drug for leishmaniasis-is unavailable to people who need it the most. BMJ Glob Heal. 2018;3:1\u201310. .","journal-title":"BMJ Glob Heal"},{"key":"e_1_3_7_101_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021556"},{"key":"e_1_3_7_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis474"},{"key":"e_1_3_7_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu039"},{"key":"e_1_3_7_104_1","doi-asserted-by":"publisher","DOI":"10.1086\/318122"},{"key":"e_1_3_7_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-017-0570-0"},{"key":"e_1_3_7_106_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1999.11813462"},{"key":"e_1_3_7_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00457-7"},{"key":"e_1_3_7_108_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S106821"},{"key":"e_1_3_7_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.11.005"},{"key":"e_1_3_7_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100220"},{"key":"e_1_3_7_111_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00292-12"},{"key":"e_1_3_7_112_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00061-07"},{"key":"e_1_3_7_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6976.12032"},{"key":"e_1_3_7_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv354"},{"key":"e_1_3_7_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv355"},{"key":"e_1_3_7_116_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.456"},{"key":"e_1_3_7_117_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03305-14"},{"key":"e_1_3_7_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit102"},{"key":"e_1_3_7_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-1969-z"},{"key":"e_1_3_7_120_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.9.2468-2474.2001"},{"key":"e_1_3_7_121_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00587-08"},{"key":"e_1_3_7_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05653.x"},{"key":"e_1_3_7_123_1","first-page":"897","article-title":"Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance","volume":"51","author":"Coon JS","year":"1991","unstructured":"Coon JS, Knudson W, Clodfelter K, et al. Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance. Cancer Res. 1991;51:897\u2013902. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1988130.","journal-title":"Cancer Res"},{"key":"e_1_3_7_124_1","first-page":"4199","article-title":"Reversal of the multidrug resistance phenotype with cremophor EL, a common vehicle for water-insoluble vitamins and drugs","volume":"50","author":"Woodcock DM","year":"1990","unstructured":"Woodcock DM, Jefferson S, Linsenmeyer ME, et al. Reversal of the multidrug resistance phenotype with cremophor EL, a common vehicle for water-insoluble vitamins and drugs. Cancer Res. 1990;50:4199\u20134203. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2364376.","journal-title":"Cancer Res"},{"key":"e_1_3_7_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1992.217"},{"key":"e_1_3_7_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.05.033"},{"key":"e_1_3_7_127_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00524-10"},{"key":"e_1_3_7_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(05)61006-8"},{"key":"e_1_3_7_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70151-7"},{"key":"e_1_3_7_130_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001692"},{"key":"e_1_3_7_131_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00173-11"},{"key":"e_1_3_7_132_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00030-11"},{"key":"e_1_3_7_133_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004304"},{"key":"e_1_3_7_134_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.64.1.29-39.1952"},{"key":"e_1_3_7_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70011-6"},{"key":"e_1_3_7_136_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00048-18"},{"key":"e_1_3_7_137_1","unstructured":"World Health Organization. https:\/\/www.who.int\/leishmaniasis\/burden\/Operational_guidelines_on_kala_azar_elimination_in_India.pdf?ua=1 (Accessed 01 Sept 2020).."},{"key":"e_1_3_7_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00790"},{"key":"e_1_3_7_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.01.047"},{"key":"e_1_3_7_140_1","unstructured":"Ward LB. A Medical Wonder That Isn\u2019t \u2013 yet. New York Times. 1990 May 6;Section 3 Page 12."},{"key":"e_1_3_7_141_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2015.1314"},{"key":"e_1_3_7_142_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh281"},{"key":"e_1_3_7_143_1","doi-asserted-by":"publisher","DOI":"10.1080\/107175400455137"},{"key":"e_1_3_7_144_1","doi-asserted-by":"publisher","DOI":"10.3109\/08982104.2011.575381"},{"key":"e_1_3_7_145_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S106548"},{"key":"e_1_3_7_146_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S196421"},{"key":"e_1_3_7_147_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-37873\/v1"},{"key":"e_1_3_7_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2013.06.001"},{"key":"e_1_3_7_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2013.01.061"},{"key":"e_1_3_7_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2020.124804"},{"key":"e_1_3_7_151_1","doi-asserted-by":"publisher","DOI":"10.3109\/02652048.2012.752532"},{"key":"e_1_3_7_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2014.06.007"},{"key":"e_1_3_7_153_1","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2020.1785457"},{"key":"e_1_3_7_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2020.05.029"},{"key":"e_1_3_7_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-020-00712-9"},{"key":"e_1_3_7_156_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2018-0038"},{"key":"e_1_3_7_157_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6528\/ab373e"},{"key":"e_1_3_7_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10061152"},{"key":"e_1_3_7_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.10.044"},{"key":"e_1_3_7_160_1","first-page":"2663","article-title":"Overexpressed Macrophage Mannose Receptor Targeted Nanocapsules- Mediated Cargo Delivery Approach for Eradication of Resident Parasite: in Vitro and In Vivo Studies","volume":"32","author":"Asthana S","year":"2015","unstructured":"Asthana S, Gupta PK, Jaiswal AK, et al. Overexpressed Macrophage Mannose Receptor Targeted Nanocapsules- Mediated Cargo Delivery Approach for Eradication of Resident Parasite: in Vitro and In Vivo Studies. Pharm Res. 2015;32:2663\u20132677.","journal-title":"Pharm Res"},{"key":"e_1_3_7_161_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn189"},{"key":"e_1_3_7_162_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.12.74"},{"key":"e_1_3_7_163_1","first-page":"e1021","article-title":"Crucial CD8+ T-lymphocyte cytotoxic role in amphotericin B nanospheres efficacy against experimental visceral leishmaniasis, Nanomedicine Nanotechnology","volume":"10","author":"Costa Lima SA","year":"2014","unstructured":"Costa Lima SA, Silvestre R, Barros D, et al. Crucial CD8+ T-lymphocyte cytotoxic role in amphotericin B nanospheres efficacy against experimental visceral leishmaniasis, Nanomedicine Nanotechnology. BiolMed. 2014;10:e1021\u2013e1030.","journal-title":"BiolMed"},{"key":"e_1_3_7_164_1","doi-asserted-by":"publisher","DOI":"10.3109\/10611860903115290"},{"key":"e_1_3_7_165_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2014.917076"},{"key":"e_1_3_7_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp3005098"},{"key":"e_1_3_7_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.04.013"},{"key":"e_1_3_7_168_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.14.116"},{"key":"e_1_3_7_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00434-2"},{"key":"e_1_3_7_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69276-5"},{"key":"e_1_3_7_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111279"},{"key":"e_1_3_7_172_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.62886"},{"key":"e_1_3_7_173_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S14787"},{"key":"e_1_3_7_174_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666171122111132"},{"key":"e_1_3_7_175_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-5362.235156"},{"key":"e_1_3_7_176_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr002"},{"key":"e_1_3_7_177_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15051037"},{"key":"e_1_3_7_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.101174"}],"container-title":["Expert Opinion on Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425247.2021.1853701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T16:13:04Z","timestamp":1770394384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425247.2021.1853701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,14]]},"references-count":176,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,3]]}},"alternative-id":["10.1080\/17425247.2021.1853701"],"URL":"https:\/\/doi.org\/10.1080\/17425247.2021.1853701","relation":{},"ISSN":["1742-5247","1744-7593"],"issn-type":[{"value":"1742-5247","type":"print"},{"value":"1744-7593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,14]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}