{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:10:47Z","timestamp":1790244647718,"version":"4.1.0"},"reference-count":111,"publisher":"Informa UK Limited","issue":"7","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"published-print":{"date-parts":[[2016,7,2]]},"DOI":"10.1080\/17425255.2016.1190831","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T14:21:17Z","timestamp":1463494877000},"page":"789-802","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":24,"title":["Hepatotoxicity of targeted therapy for cancer"],"prefix":"10.1080","volume":"12","author":[{"given":"Kirsty Wai-Chung","family":"Lee","sequence":"first","affiliation":[{"name":"Sir YK Pao Center for Cancer, Department of Clinical Oncology, State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Hong Kong Cancer Institute and Prince of Wales Hospital, Shatin, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Lam","family":"Chan","sequence":"additional","affiliation":[{"name":"Sir YK Pao Center for Cancer, Department of Clinical Oncology, State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Hong Kong Cancer Institute and Prince of Wales Hospital, Shatin, Hong Kong"},{"name":"Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,6,6]]},"reference":[{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0048-4"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12231"},{"key":"CIT0004","volume-title":"Pazopanib","year":"2009"},{"key":"CIT0005","volume-title":"Sunitinib","year":"2011"},{"key":"CIT0006","volume-title":"Regorafenib","year":"2012"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2015.01.026"},{"key":"CIT0008","volume-title":"Gefitinib","year":"2015"},{"key":"CIT0009","volume-title":"Erlotinib","year":"2010"},{"key":"CIT0010","volume-title":"Afatinib","year":"2015"},{"key":"CIT0011","volume-title":"Lapatinib","year":"2010"},{"key":"CIT0012","volume-title":"LiverTox: clinical and research information on drug-induced liver injury"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.011"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2005.05.006"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.02.012"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.001"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20800"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1993.12.1"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(98)00109-9"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1080\/004982598238868"},{"key":"CIT0021","first-page":"REVIEWS3003","volume":"1","author":"Werk-Riechhart D","year":"2000","journal-title":"Genome Biol"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.2174\/1389200023337054"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1351"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(95)02013-6"},{"key":"CIT0025","first-page":"277","volume":"3","author":"Murray M","year":"1999","journal-title":"Int J Mol Med"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-12-RV-096"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/854015"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3921"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds249"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.029660"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03911.x"},{"key":"CIT0032","first-page":"1","volume":"32","author":"Nassar I","year":"2010","journal-title":"Malays J Pathol"},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"6608","DOI":"10.3748\/wjg.v13.i48.6608","volume":"13","author":"Ridruejo E","year":"2007","journal-title":"World J Gastroenterol"},{"key":"CIT0034","volume-title":"Summary of product characteristics \u201cGlivec\u201d 21\/02\/2012. Glivec-EMEA\/H\/C\/000406-II\/0070","author":"Committee for Medicinal Products for Human Use"},{"key":"CIT0035","volume-title":"Imatinib","year":"2001"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03810.x"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.011"},{"key":"CIT0038","first-page":"703","volume-title":"Schiff\u2019s diseases of the liver","author":"Shivakumar C","year":"2012"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2007.06.011"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909530"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70364-X"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.7109"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-014-1768-2"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000323"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.10.112"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg250"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.03.100"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.03.038"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.038"},{"issue":"1","key":"CIT0050","first-page":"91","volume":"43","author":"Imai A","year":"2016","journal-title":"Gan To Kagaku Ryoho"},{"issue":"9","key":"CIT0051","first-page":"5211","volume":"34","author":"Yonesaka K","year":"2014","journal-title":"Anticancer Res"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/354657"},{"key":"CIT0053","first-page":"812972","volume":"2011","author":"Nagano T","year":"2011","journal-title":"Case Rep Pulmonol"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.6285"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-593"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2010.08.012"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.3368"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2013.03.003"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2015.08.004"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.06.001"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310129"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199716010-00001"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2140-5"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.13.24"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i18.2349"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.3197"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.9867"},{"key":"CIT0068","doi-asserted-by":"crossref","first-page":"abstr 617","DOI":"10.1200\/jco.2015.33.3_suppl.617","volume":"33","author":"Spraggs CF","year":"2015","journal-title":"J Clin Oncol"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2044"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.09.028"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511023331802"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605653"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt394"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2484"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.SABCS-09-1112"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0553-z"},{"key":"CIT0077","first-page":"191","volume":"6","author":"Saif MW","year":"2008","journal-title":"Clin Adv Hematol Oncol"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-009-9284-y"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1159\/000111092"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.5359"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.0332"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-18-22"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.8543"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9099-5"},{"issue":"7","key":"CIT0085","first-page":"3629","volume":"34","author":"Walker EJ","year":"2014","journal-title":"Anticancer Res"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0386-2"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i8.1318"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12132"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-013-0371-4"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v5.i1.43"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2681-0"},{"key":"CIT0092","volume-title":"LiverTox: clinical and research information on drug-induced liver injury: drug record: Rituximab"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281115"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.149245"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701509848"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1046\/j.0902-4441.2004.00180.x"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00375.x"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20705"},{"key":"CIT0099","volume-title":"Pembrolizumab","year":"2014"},{"key":"CIT0100","volume-title":"Nivolumab","year":"2014"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.14.36"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.9624"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.3824"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.29.15_suppl.3106"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3279"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.41"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-590"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181daac69"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01982_19.x"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M457"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/941395"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61613-9"}],"container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2016.1190831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T19:12:18Z","timestamp":1567883538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2016.1190831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,6]]},"references-count":111,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,5,17]]},"published-print":{"date-parts":[[2016,7,2]]}},"alternative-id":["10.1080\/17425255.2016.1190831"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2016.1190831","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}