{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:07:00Z","timestamp":1770487620495,"version":"3.49.0"},"reference-count":56,"publisher":"Informa UK Limited","issue":"10","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"published-print":{"date-parts":[[2016,10,2]]},"DOI":"10.1080\/17425255.2016.1218847","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T07:47:59Z","timestamp":1470037679000},"page":"1233-1246","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacokinetics, pharmacodynamics and clinical efficacy of ospemifene for the treatment of dyspareunia and genitourinary syndrome of menopause"],"prefix":"10.1080","volume":"12","author":[{"given":"Chiara","family":"Bondi","sequence":"first","affiliation":[{"name":"Academic Unit of Obstetrics and Gynaecology, IRCCS AOU San Martino \u2013 IST, Genova, Italy"},{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Academic Unit of Obstetrics and Gynaecology, IRCCS AOU San Martino \u2013 IST, Genova, Italy"},{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Scala","sequence":"additional","affiliation":[{"name":"Academic Unit of Obstetrics and Gynaecology, IRCCS AOU San Martino \u2013 IST, Genova, Italy"},{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Tafi","sequence":"additional","affiliation":[{"name":"Academic Unit of Obstetrics and Gynaecology, IRCCS AOU San Martino \u2013 IST, Genova, Italy"},{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Racca","sequence":"additional","affiliation":[{"name":"Academic Unit of Obstetrics and Gynaecology, IRCCS AOU San Martino \u2013 IST, Genova, Italy"},{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Luigi","family":"Venturini","sequence":"additional","affiliation":[{"name":"Academic Unit of Obstetrics and Gynaecology, IRCCS AOU San Martino \u2013 IST, Genova, Italy"},{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Leone Roberti Maggiore","sequence":"additional","affiliation":[{"name":"Academic Unit of Obstetrics and Gynaecology, IRCCS AOU San Martino \u2013 IST, Genova, Italy"},{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2016,8,9]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.07.013"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12686"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.6118\/jmm.2015.21.2.65"},{"key":"CIT0004","volume-title":"Presented at: 18th Annual Meeting of The North American Menopause Society","author":"Simon JA","year":"2007"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2013.871696"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2005.pto960103.x"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1210\/mend.11.6.0009"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e318223e82a"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2236"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1129166"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66455-0"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1079100"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000401"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2014.899347"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2014.975197"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1071608"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1045485"},{"key":"CIT0018","first-page":"225","volume":"68","author":"Vicariotto F","year":"2016","journal-title":"Minerva Ginecol"},{"key":"CIT0019","unstructured":"[cited 2016 April 12]. Available from: http:\/\/www.chemspider.com\/Chemical-Structure.2300501.html?rid=158fce9e-fe54-43ed-b961-ba4fe77ff9c5"},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/gme.0b013e3181c1ac01","volume":"17","author":"Bachmann GA","year":"2010","journal-title":"Menopause"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e318279ba64"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.02.015"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.17.3172"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.2.7342"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1007\/s002280000176"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.5414\/CP201873"},{"key":"CIT0027","first-page":"448","volume":"5","author":"Gennari L","year":"2004","journal-title":"Curr Opin Investig Drugs"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/bdd.1853","volume":"34","author":"Lehtinen T","year":"2013","journal-title":"Biopharm Drug Dispos"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707232"},{"key":"CIT0030","first-page":"139","volume":"1","author":"Labrie F","year":"2010","journal-title":"Horm Mol Biol Clin Invest"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0514"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2003.11.009"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2005.06.027"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1097\/01.GME.0000063566.84134.98"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1097\/01.GME.0000063609.62485.27"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1080\/09513590410001672197"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1097\/00042192-200512020-00015"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2014.954996"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2013.834493"},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/gme.0b013e31826d36ba","volume":"20","author":"Simon JA","year":"2013","journal-title":"Menopause"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000275"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0b013e3182a122c2"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S44579"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.161"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0b013e318295236f"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12235"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2011.647840"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12190"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1107039"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1113517"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2014.975199"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(01)00066-8"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.04.004"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2013.09.003"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2015.06.005"},{"key":"CIT0056","unstructured":"Osphena\u2122 (ospemifene). [prescribing information]. Florham Park (NJ): Shionogi, Inc; 2013."}],"container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2016.1218847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T16:28:44Z","timestamp":1718728124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2016.1218847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,9]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10,2]]}},"alternative-id":["10.1080\/17425255.2016.1218847"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2016.1218847","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}