{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:30:36Z","timestamp":1787729436178,"version":"build-2784847793"},"reference-count":120,"publisher":"Informa UK Limited","issue":"12","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"published-print":{"date-parts":[[2016,12,1]]},"DOI":"10.1080\/17425255.2016.1225037","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T07:39:29Z","timestamp":1471505969000},"page":"1445-1461","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":42,"title":["Drug-drug interactions of non-vitamin K oral anticoagulants"],"prefix":"10.1080","volume":"12","author":[{"given":"Christos","family":"Voukalis","sequence":"first","affiliation":[{"name":"University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Shantsila","sequence":"additional","affiliation":[{"name":"University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,8,26]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08753.x"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-10-0772"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv309"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu283"},{"issue":"2","key":"CIT0006","doi-asserted-by":"crossref","first-page":"e44S","DOI":"10.1378\/chest.11-2292","volume":"141","author":"Ageno W","year":"2012","journal-title":"Chest"},{"issue":"73","key":"CIT0007","first-page":"433","volume":"13","author":"Ahrens I","year":"2012","journal-title":"Discov Med"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.180240"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1021\/mp0500871"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1080\/00498250701867889"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00079"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3028"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.058"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.01100.x"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005274550"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-08-0551"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04498.x"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.019083"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1177\/0091270010393342"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008324179"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02899.x"},{"key":"CIT0022","author":"Dansirikul","year":"2012","journal-title":"Thromb Haemost"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00890.x"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.053769"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"CIT0026","unstructured":"Pradaxa, INN-dabigatran etexilate - WC500041059.pdf. Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/human\/000829\/WC500041059.pdf"},{"key":"CIT0027","unstructured":"CLINICAL PHARMACOLOGY AND BIOPHARMACEUTICS REVIEW \u2013 DABIGATRAN; [cited 2016 Jan 23]. Available from: http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2010\/022512Orig1s000ClinPharmR_Corrrected 3.11.2011.pdf"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.314"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.03.013"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04453.x"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.3109\/10837450.2010.522582"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12055"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1159\/000352062"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04218.x"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1698"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1177\/0091270010393342"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.115386"},{"key":"CIT0038","volume-title":"Meeting of the Cardiovascular and Renal Drugs Advisory Committee","author":"U.S. Food and Drug Administration \u2013 FDA Briefing Information","year":"2010"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-04-0319"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.06.034"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256595"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.004747"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847010-00005"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12154"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-08-0589"},{"issue":"73","key":"CIT0046","first-page":"433","volume":"13","author":"Ahrens I","year":"2012","journal-title":"Discov Med"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.57.070188.004411"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.202978"},{"key":"CIT0049","unstructured":"Colman E. U. S. food and drug administration notice: archived document [Internet]. [cited 2016 Jan 23]. Available from: http:\/\/www.fda.gov\/downloads\/AdvisoryCom.e\/UCM225627.pdf"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.025569"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-005-0043-5"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802361499"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.5414\/CP201812"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-03-0196"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03753.x"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12054"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.09.004"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12075"},{"issue":"232","key":"CIT0059","first-page":"227","volume":"39","author":"Elikowski W","year":"2015","journal-title":"Pol Merkur Lekarski"},{"key":"CIT0060","unstructured":"Xarelto, INN-rivaroxaban - WC500057108.pdf [Internet]; [cited 2016 Jan 23]. Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/human\/000944\/WC500057108.pdf"},{"issue":"2","key":"CIT0061","first-page":"125","volume":"66","author":"Bates D","year":"2013","journal-title":"Can J Hosp Pharm"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014523115"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1177\/030006051204000508"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.26"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12349"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02776.x"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006292127"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.3390\/ph5030279"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60738-8"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.04.011"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006286904"},{"key":"CIT0072","unstructured":"FDA U.S. Food and Drug Administration \u2013 Rivaroxaban; [cited 2016 Jan 23]. Available from: http:\/\/www.fda.gov\/downloads\/AdvisoryCommittees\/CommitteesMeetingMaterials\/Drugs\/CardiovascularandRenalDrugsAdvisoryCommittee\/UCM181524.pdf"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.023143"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04369.x"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-011-0037-x"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.023143"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.029694"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.050260"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-013-0034-0"},{"key":"CIT0080","author":"Chang M","year":"2015","journal-title":"J Clin Pharmacol"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.065"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.07.010"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12541"},{"key":"CIT0084","unstructured":"Eliquis II-14 Summary of opinion - WC500169373.pdf; [cited 2016 Jan 18]. Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Summary_of_opinion\/human\/002148\/WC500169373.pdf"},{"key":"CIT0085","unstructured":"EVALUATION and RESEARCH. Center for drug evaluation and clinical pharmacology and biopharmaceutics review (S) [Internet]. 2009. p. 1\u20135. [cited 2016 Jan 23]. Available from http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2010\/022527orig1s000clinpharmr.pdf"},{"key":"CIT0086","unstructured":"PRODUCT INFORMATION-apixaban-ELIQUIS\u00ae; [cited 2016 Jan 23]. Available from: http:\/\/secure.healthlinks.net.au\/content\/bms\/pi.cfm?product=bqpeliqu11112"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht445"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-09-0634"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.832139"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12393"},{"key":"CIT0091","first-page":"59","volume":"5","author":"Upreti VV","year":"2013","journal-title":"Clin Pharmacol"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-015-0157-9"},{"issue":"4","key":"CIT0093","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1160\/TH07-04-0312","volume":"98","author":"Zafar MU","year":"2007","journal-title":"Thromb Haemost"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0261-1"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.046888"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-013-0029-0"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1177\/0091270010383858"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.054866"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.550"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.06.042"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12230"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310907"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-02-0181"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31826265b6."},{"key":"CIT0105","unstructured":"LIXIANA, INN-EDOXABAN - SUMMARY OF PRODUCT CHARACTERISTICS; [cited 2016 Jan 31].Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/human\/002629\/WC500189045.pdf"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-015-0298-2"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3182970991"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306638"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-09-0676"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-12-1032"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-12-1028"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024964"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu298"},{"issue":"3","key":"CIT0114","first-page":"ehv320","volume":"37","author":"Roffi M","year":"2015","journal-title":"Eur Heart J"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs215"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.029"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht049"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-07-0552"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.010"},{"issue":"6","key":"CIT0120","first-page":"672","volume":"8","author":"Smith JG","year":"2012","journal-title":"EuroIntervention J Eur Collab with Work Gr Interv Cardiol Eur Soc Cardiol"}],"container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2016.1225037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T23:28:41Z","timestamp":1598743721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2016.1225037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,26]]},"references-count":120,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12,1]]}},"alternative-id":["10.1080\/17425255.2016.1225037"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2016.1225037","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,26]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}