{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:12:21Z","timestamp":1789665141389,"version":"4.0.1"},"reference-count":127,"publisher":"Informa UK Limited","issue":"4","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1054146"],"award-info":[{"award-number":["1054146"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"published-print":{"date-parts":[[2017,4,3]]},"DOI":"10.1080\/17425255.2017.1269745","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T05:56:15Z","timestamp":1481176575000},"page":"449-462","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":21,"title":["Allopurinol: insights from studies of dose\u2013response relationships"],"prefix":"10.1080","volume":"13","author":[{"given":"Richard O.","family":"Day","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology &amp; Toxicology, St Vincent\u2019s Hospital, Darlinghurst, Sydney, Australia"},{"name":"St Vincent\u2019s Clinical School, UNSW Australia, Darlinghurst, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diluk R.W.","family":"Kannangara","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology &amp; Toxicology, St Vincent\u2019s Hospital, Darlinghurst, Sydney, Australia"},{"name":"St Vincent\u2019s Clinical School, UNSW Australia, Darlinghurst, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie L.","family":"Stocker","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology &amp; Toxicology, St Vincent\u2019s Hospital, Darlinghurst, Sydney, Australia"},{"name":"School of Medical Sciences, UNSW Australia, Kensington, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Carland","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology &amp; Toxicology, St Vincent\u2019s Hospital, Darlinghurst, Sydney, Australia"},{"name":"School of Medical Sciences, UNSW Australia, Kensington, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology &amp; Toxicology, St Vincent\u2019s Hospital, Darlinghurst, Sydney, Australia"},{"name":"School of Medical Sciences, UNSW Australia, Kensington, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry G.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology &amp; Toxicology, St Vincent\u2019s Hospital, Darlinghurst, Sydney, Australia"},{"name":"School of Medical Sciences, UNSW Australia, Kensington, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.91"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150310"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3039-2"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep364"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150607"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39449.819271.BE"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201215"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1002\/art.23245"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.055251"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1002\/art.39254"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00346-9"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90441-4"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208111"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-48"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205877"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev350"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147939"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0802-3"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1002\/art.30389"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.151199"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-43227"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-32-379-472"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209707"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12557"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21772"},{"key":"CIT0026","first-page":"577","volume":"28","author":"Li-Yu J","year":"2001","journal-title":"J Rheumatol"},{"issue":"275","key":"CIT0027","first-page":"v","volume":"32","author":"Becker MA","year":"2006","journal-title":"Rheum Dis Clin North Am"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746080-00001"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90743-5"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12799"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04207.x"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101160"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131302"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1988.tb03401.x"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.03116.x"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(90)90107-4"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04349.x"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1080\/15257770802146577"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.05.022"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(66)90163-8"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-014-1210-x"},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/S0021-9258(18)63065-0","volume":"245","author":"Massey V","year":"1970","journal-title":"J Biol Chem"},{"key":"CIT0043","first-page":"498","volume":"23","author":"Walter-Sack I","year":"1996","journal-title":"J Rheumatol"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.055269"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1002\/art.30119"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1478-8"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.89"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2015.101"},{"key":"CIT0049","first-page":"1646","volume":"33","author":"Dalbeth N","year":"2006","journal-title":"J Rheumatol"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201687"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.4065\/81.7.925"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1186\/ar2659"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.05.007"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140588"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1997.53711.x"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1991.tb03888.x"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1988.tb03402.x"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198106060-00002"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/26.6.445"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328330a3b8"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0084-0"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315424"},{"key":"CIT0063","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5694\/j.1326-5377.1995.tb138436.x","volume":"162","author":"Peterson GM","year":"1995","journal-title":"Med J Aust"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.10.981"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1002\/art.23007"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.113"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem056a"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22785"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.32"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12126"},{"key":"CIT0072","first-page":"13","volume":"45","author":"Kannangara D","year":"2015","journal-title":"Internal Medicine Journal"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1002\/art.34488"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.132"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409500102"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120803"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080814"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110092"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111161"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2015.07.011"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302700317"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-209109"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205577"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1080\/15257770802136032"},{"key":"CIT0085","doi-asserted-by":"crossref","first-page":"182","DOI":"10.5694\/j.1326-5377.1993.tb137784.x","volume":"159","author":"Kot TV","year":"1993","journal-title":"Med J Aust"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201676"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft378"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0610-9"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.11.094"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1002\/art.23121"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0800885"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.143"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.01.013"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2015.02.004"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1002\/art.30520"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201254"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13006"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.154997"},{"key":"CIT0099","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/RHU.0000000000000140","volume":"20","author":"Kimura-Hayama E","year":"2014","journal-title":"J Clin Rheumatol"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206397"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2005.05.007"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.11.2840"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1007\/s004390051050"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007040426"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12661"},{"key":"CIT0106","first-page":"22","volume":"147","author":"Nyhan WL","year":"2005","journal-title":"Contrib Nephrol"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1002\/art.24617"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.3290"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.06.007"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-1-44"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1002\/art.10792"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1159\/000186593"},{"key":"CIT0113","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature742","volume":"417","author":"Enomoto A","year":"2002","journal-title":"Nature"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000504"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2500"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61343-4"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206191"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1038\/ng.106"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1186\/ar4020"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1159\/000184368"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2016.04.007"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780080429"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1756"},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000237"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.1038\/srep03755"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097646"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.09.007"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20663"}],"container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2017.1269745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T15:56:09Z","timestamp":1657986969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2017.1269745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":127,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,2,9]]},"published-print":{"date-parts":[[2017,4,3]]}},"alternative-id":["10.1080\/17425255.2017.1269745"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2017.1269745","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,20]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}