{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:37:25Z","timestamp":1792453045151,"version":"4.5.0"},"reference-count":62,"publisher":"Informa UK Limited","issue":"9","funder":[{"name":"LEO Pharma"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"published-print":{"date-parts":[[2018,9,2]]},"DOI":"10.1080\/17425255.2018.1508449","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T14:13:25Z","timestamp":1533305605000},"page":"911-918","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacokinetic and pharmacodynamic evaluation of ingenol mebutate for the treatment of actinic keratosis"],"prefix":"10.1080","volume":"14","author":[{"given":"Eggert","family":"Stockfleth","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Dermatologie, Venerologie und Allergologie, St. Josef-Hospital, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Bastian","sequence":"additional","affiliation":[{"name":"Scientific Affairs, LEO Pharma GmbH, Neu-Isenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.09.053"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.10.001"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2010.507191"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103339"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24284"},{"key":"CIT0006","unstructured":"Werner RN, Stockfleth E, Connolly SM, et al. Evidence and consensus based (S3) guidelines for the treatment of actinic keratosis. 2015 [cited 2015 Aug 28]. Available from: http:\/\/www.euroderm.org\/edf\/index.php\/edf-guidelines\/category\/5-guidelines-miscellaneous?download=23:guideline-management-of-actinic-keratoses-update-2015"},{"key":"CIT0007","first-page":"1727","volume":"63","author":"Braakhuis BJM","year":"2003","journal-title":"Cancer Res"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14092"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S9910"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.134"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.6.722"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03541.x"},{"key":"CIT0013","unstructured":"Rosso JQ, Kircik L, Goldenberg G, et al. Comprehensive management of actinic keratoses. J Clin Aesthet Dermatol. 2014;7(9Suppl S2-S12): S2\u2013S12."},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5694\/j.1326-5377.1990.tb124456.x","volume":"152","author":"Marks R","year":"1990","journal-title":"Med J Aust"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13180"},{"key":"CIT0016","first-page":"8","volume":"70","author":"Gupta AK","year":"2002","journal-title":"Cutis"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12434"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11085.x"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07860.x"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-015-0070-9"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12848"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1517\/14656560903382622"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2837"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S28905"},{"key":"CIT0025","first-page":"616","volume":"14","author":"Braun SA","year":"2016","journal-title":"J Dtsch Dermatol Ges"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.12.038"},{"key":"CIT0027","first-page":"1181","volume":"11","author":"Stahlhut M","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160096"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3403"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1158\/1535-7163.1651.3.12","volume":"3","author":"Gillespie SK","year":"2004","journal-title":"Mol Cancer Ther"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-4117"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.8123"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-15-0023-T"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.7b00420"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-008-0458-9"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.04.037"},{"key":"CIT0037","unstructured":"European Medicines Agency. Picato: EPAR \u2013 public assessment report 2012. [cited 2015 Jul 10]. Available from: http:\/\/www.ema.europa.eu\/ema\/index.jsp?curl=pages\/medicines\/human\/medicines\/002275\/human_med_001600.jsp&mid=WC0b01ac058001d124"},{"key":"CIT0038","first-page":"19","volume":"7","author":"Anderson L","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1329506"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.418"},{"key":"CIT0041","first-page":"1181","volume":"15","author":"Ulrich M","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"CIT0042","first-page":"18","volume":"9","author":"Markowitz O","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1111170"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.036"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13211"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14222"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.2766"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16048"},{"key":"CIT0049","first-page":"154","volume":"13","author":"Berman B","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"CIT0050","first-page":"1353","volume":"13","author":"Berman B","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S111305"},{"key":"CIT0052","first-page":"35","volume":"7","author":"Dosik JS","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-014-0059-9"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13063"},{"key":"CIT0055","first-page":"112","volume":"16","author":"Jim On SC","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2015.09.011"},{"key":"CIT0057","unstructured":"SmpC Picato\u00ae. Picato 150\u00a0mcg\/g gel. [updated 29 Apr 2016; cited 2016 Nov 29]. Available from: https:\/\/www.medicines.org.uk\/emc\/medicine\/27246"},{"key":"CIT0058","unstructured":"LEO Pharma. Picato\u00ae (ingenol mebutate) gel, 0.015%, 0.05%. Prescribing information. 2015. [cited 2015 Aug 10]. Available from: https:\/\/www.picato.com\/_pdf\/PrescribingInformation.pdf"},{"key":"CIT0059","first-page":"1","volume":"43","author":"Braun S","year":"2016","journal-title":"Dermatol Surg"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-015-1561-3"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13021"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2016.1160024"}],"container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2018.1508449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T18:52:55Z","timestamp":1661712775000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2018.1508449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":62,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9,2]]}},"alternative-id":["10.1080\/17425255.2018.1508449"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2018.1508449","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}