{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T23:07:58Z","timestamp":1769382478881,"version":"3.49.0"},"reference-count":77,"publisher":"Informa UK Limited","issue":"10","funder":[{"DOI":"10.13039\/501100002336","name":"Daiichi Sankyo Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"published-print":{"date-parts":[[2018,10,3]]},"DOI":"10.1080\/17425255.2018.1530213","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T07:01:47Z","timestamp":1538463707000},"page":"1057-1069","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":51,"title":["Pharmacokinetics of new oral anticoagulants: implications for use in routine care"],"prefix":"10.1080","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-6111","authenticated-orcid":false,"given":"Ylenia","family":"Ingrasciotta","sequence":"first","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morpho-functional Imaging, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Crisafulli","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morpho-functional Imaging, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Pizzimenti","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pharmacology, A.O.U. Policlinico \u201cG. Martino\u201d, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-7765","authenticated-orcid":false,"given":"Ilaria","family":"Marcian\u00f2","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pharmacology, A.O.U. Policlinico \u201cG. Martino\u201d, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morpho-functional Imaging, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"And\u00f2","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Section of Cardiology, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Corrao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Relevance and High Specialization Hospital Trust, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piera","family":"Capranzano","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Trifir\u00f2","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morpho-functional Imaging, University of Messina, Messina, Italy"},{"name":"Unit of Clinical Pharmacology, A.O.U. Policlinico \u201cG. Martino\u201d, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"CIT0003","first-page":"69","volume":"14","author":"Di Pasquale G","year":"2013","journal-title":"G Ital Cardiol"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.1.41"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107039"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310907"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.114.001556"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1302834"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.020"},{"key":"CIT0012","volume":"3189","author":"Larsen TB","year":"2016","journal-title":"Bmj [Internet]"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012061"},{"key":"CIT0014","first-page":"3961","volume":"19","author":"Russo V","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"CIT0015","first-page":"3","volume":"17","author":"Pelliccia F","year":"2016","journal-title":"Focus su apixaban"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-10-0840"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv466"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.09.037"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1237937"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003725"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.08.074"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003074"},{"key":"CIT0023","first-page":"3S","volume":"16","author":"Ferri N","year":"2015","journal-title":"G Ital Cardiol"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2010.017"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.5_Supplement.445S"},{"key":"CIT0027","first-page":"2137","volume":"38","author":"Heidbuchel H","year":"2017","journal-title":"Eur Heart J"},{"key":"CIT0028","volume-title":"Interazioni TAO, AVK e NAO, progetto FarmAmico","author":"Regione Lombardia"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168750"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq278"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv309"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1698"},{"key":"CIT0033","volume":"33","author":"Hager N","year":"2017","journal-title":"Can J Cardiol [Internet]"},{"key":"CIT0034","first-page":"63","volume":"5","author":"Serra W","year":"2015","journal-title":"Clin Pract [Internet]"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256595"},{"key":"CIT0037","first-page":"3S","volume":"17","author":"Nardi F","year":"2016","journal-title":"G Ital Cardiol"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12836"},{"issue":"1","key":"CIT0039","doi-asserted-by":"crossref","first-page":"47","DOI":"10.31887\/DCNS.2007.9.1\/dhalperin","volume":"9","author":"Reber G.","year":"2007","journal-title":"Dialogues Clin Neurosci"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014540868"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO-14-11-0063"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.082"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.01.013"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy031"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.303"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.04.015"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.03.600"},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"w14356","DOI":"10.4414\/smw.2016.14356","volume":"146","author":"Sadlon AH","journal-title":"Swiss Med Wkly [Internet]"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(16)30799-9"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.07.007"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-04-0350"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.113.000192"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2014.933577"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu319"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2016.1142432"},{"key":"CIT0058","first-page":"884","volume":"17","author":"Cemin R","year":"2016","journal-title":"G Ital Cardiol"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113572"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906598"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302507"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12241"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12845"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.03.023"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2015.1077213"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2015.1096242"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2016.22.11.1319"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13299"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68845-4"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.114967"},{"key":"CIT0072","first-page":"213","author":"Valgimigli M","year":"2017","journal-title":"Eur J Cardio-Thoracic Surg [Internet]"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611594"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708454"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.816082"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61943-7"},{"key":"CIT0077","first-page":"20","volume":"56","author":"Terrovitis JV","year":"2015","journal-title":"Hell J Cardiol"},{"key":"CIT0078","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.rce.2013.11.008","volume":"214","author":"Fern\u00e1ndez de Velasco P\u00e9rez D","year":"2014","journal-title":"Rev Clin Esp [Internet]"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.008428"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.10.016"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3181492929"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.02.018"}],"container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2018.1530213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:01:39Z","timestamp":1761091299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2018.1530213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,2]]},"references-count":77,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,5]]},"published-print":{"date-parts":[[2018,10,3]]}},"alternative-id":["10.1080\/17425255.2018.1530213"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2018.1530213","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}