{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:01:06Z","timestamp":1793066466179,"version":"4.5.0"},"reference-count":104,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"published-print":{"date-parts":[[2019,2,1]]},"DOI":"10.1080\/17425255.2019.1563071","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T08:56:19Z","timestamp":1547110579000},"page":"133-149","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":88,"title":["Novel \u03b2-lactam-\u03b2-lactamase inhibitor combinations: expectations for the treatment of carbapenem-resistant Gram-negative pathogens"],"prefix":"10.1080","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-0239","authenticated-orcid":false,"given":"Ilias","family":"Karaiskos","sequence":"first","affiliation":[{"name":"1st Department of Internal Medicine-Infectious Diseases, Hygeia General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-9848","authenticated-orcid":false,"given":"Irene","family":"Galani","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University General Hospital ATTIKON, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-4534","authenticated-orcid":false,"given":"Maria","family":"Souli","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University General Hospital ATTIKON, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7387-5065","authenticated-orcid":false,"given":"Helen","family":"Giamarellou","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine-Infectious Diseases, Hygeia General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12342"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2017.1410434"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12697"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.914172"},{"issue":"59","key":"CIT0005","volume":"13","author":"Karaiskos I","year":"2017","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"CIT0006","unstructured":"Summary of the latest data on antibiotic resistance in the European Union. EARS-Net surveillance data November. 2017. Available from: https:\/\/ecdc.europa.eu\/en\/publications-data\/summary-latest-data-antibiotic-resistance-european-union"},{"key":"CIT0007","unstructured":"World Health Organization: Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. 2017. Available from: http:\/\/www.who.int\/medicines\/publications\/WHO-PPL-Short_Summary_25FebET_NM_WHO.pdf."},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit152"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2017.11.002"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00001-07"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01076-18"},{"key":"CIT0013","unstructured":"National Center for Biotechnology Information. PubChem compound database. CID=56649692, Available from: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/56649692 [cited 2018 Sept]."},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2016.02.007"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01443-17"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh358"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0013-7"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1179\/1973947813Y.0000000145"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1205073109"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03057-14"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.12.101"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025247"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00091"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx050"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.08.011"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02596-17"},{"issue":"1","key":"CIT0027","first-page":"S419","volume":"5","author":"Daigle D","year":"2018","journal-title":"Infect Dis"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01549-08"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.104"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01904-17"},{"key":"CIT0031","unstructured":"AVYCAZ (ceftazidime and avibactam) for injection, for intravenous use. FDA. 2016. Available from: www.accessdata.fda.gov\/drugsatfda_docs\/lab11el\/2016\/206494s002lbl.pdf"},{"key":"CIT0032","unstructured":"European Medicines Agency. Zavicefta: summary of product characteristics. 2018. Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR__Product_Information\/human\/004027\/WC500210234.pdf"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0902-x"},{"key":"CIT0034","unstructured":"Clinical Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 28th Informational Supplement M100. Wayne, PA, USA: CLSI; 2018"},{"key":"CIT0035","unstructured":"The European Committee on Antimicrobial Susceptibility Testing-EUCAST. Clinical breakpoints. 2018. Available from: http:\/\/www.eucast.org\/"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02584-17"},{"key":"CIT0037","first-page":"1396","volume":"72","author":"Stone GG","year":"2017","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"CIT0038","doi-asserted-by":"crossref","first-page":"e 01820","DOI":"10.1128\/AAC.01820-16","volume":"61","author":"Stone GG","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"CIT0039","author":"Kazmierczak KM","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"CIT0040","author":"Kazmierczak KM","year":"2018","journal-title":"INFORM global surveillance 2012\u201315"},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.diagmicrobio.2018.04.012","volume":"92","author":"Sader HS","year":"2018","journal-title":"Diagn Microbiol Infect Dis"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-015-0283-9"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.172"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv170"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.793"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw133"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.01.010"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw378"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30747-8"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30004-4"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw636"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"e 01964","DOI":"10.1128\/AAC.01964-16","volume":"61","author":"Temkin E","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00449-17"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02497-17"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00883-17"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.03.021"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy492"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix783"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky295"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2017.09.001"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02243-16"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2018.23.30.1700775"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2015.20.45.30062"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/249856"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00206-15"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00472-17"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku568"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.07.011"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw082"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv132"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01008-17"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx496"},{"key":"CIT0073","volume-title":"A phase I, 3-part placebo-controlled randomised trial to evaluate the safety, tolerability and pharmacokinetics of aztreonam-avibactam in healthy subjects (EV0643)","author":"Edeki T","year":"2016"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0654-4"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.12.033"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2015.02.003"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02134-12"},{"key":"CIT0078","unstructured":"Vabomere\u00ae (meropenem\/vaborbactam for injection) [prescribing information]. FDA. 2017. Available from: www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/209776lbl.pdf"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00567-17"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00711-16"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00568-16"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01713-15"},{"key":"CIT0083","volume-title":"Poster presented at: ID Week 2017","author":"Mathers A","year":"2017"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01306-18"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.0438"},{"key":"CIT0086","volume-title":"Poster presented at: ID Week 2017","author":"Kaye KS","year":"2017"},{"key":"CIT0087","volume-title":"Poster presented at: ID Week","author":"Wunderink R","year":"2017"},{"key":"CIT0088","volume-title":"Poster presented at: ID Week 2017","author":"Paterson D","year":"2017"},{"key":"CIT0089","first-page":"e 01969","volume":"62","author":"Sabet M","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01694-17"},{"key":"CIT0091","volume-title":"Presented at ID week","author":"Lomovskaya O","year":"2017"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2375-0"},{"key":"CIT0093","first-page":"2286","volume":"68","author":"Livermore DM","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00830-15"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0851-9"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03706-14"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky107"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02209-16"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06113-11"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00280-18"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01411-17"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00633-16"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx139"},{"key":"CIT0104","volume-title":"Presented in 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)","author":"Motsch J","year":"2018"}],"container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2019.1563071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T21:58:23Z","timestamp":1598738303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2019.1563071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":104,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2,1]]}},"alternative-id":["10.1080\/17425255.2019.1563071"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2019.1563071","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,10]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}