{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:41:42Z","timestamp":1791232902034,"version":"4.1.0"},"reference-count":99,"publisher":"Informa UK Limited","issue":"11","funder":[{"name":"McNeil Consumer Health"},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK070195"],"award-info":[{"award-number":["DK070195"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM103549"],"award-info":[{"award-number":["GM103549"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"published-print":{"date-parts":[[2020,11,1]]},"DOI":"10.1080\/17425255.2020.1817896","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T07:01:39Z","timestamp":1598770899000},"page":"1039-1050","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":38,"title":["Novel strategies for the treatment of acetaminophen hepatotoxicity"],"prefix":"10.1080","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5324-1164","authenticated-orcid":false,"given":"Jephte Y.","family":"Akakpo","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-6980","authenticated-orcid":false,"given":"Hartmut","family":"Jaeschke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.02.026"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2013.07.001"},{"key":"cit0003","first-page":"211","volume":"187","author":"Mitchell JR","year":"1973","journal-title":"J Pharmacol Exp Ther"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2012.659252"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23267"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1186\/cc7782"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1177\/1087057114561950"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00313"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21529"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.168"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1679919"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1007-6"},{"key":"cit0013","first-page":"1029","volume":"26","author":"Williams RT","year":"1967","journal-title":"Fed Proc"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.02.005"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.08.015"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111282"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708916200"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2010.04.015"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.129445"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.04.010"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.11.017"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111240"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.01.004"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25657"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.30956"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.01.003"},{"issue":"1","key":"cit0027","first-page":"189","volume":"3","author":"Maes M","year":"2017","journal-title":"J Clin Trans Res"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.08.005"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2019.10.002"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.12.006"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080976"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23059"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20511"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20969"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.06.009"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06539.x"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017-00211"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.09.020"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6541"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.104736"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.002402"},{"key":"cit0042","first-page":"157","volume":"3","author":"Ramachandran A","year":"2017","journal-title":"J Clin Trans Res"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e3181ff7ac0"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2016.1144889"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1177\/0960327118774902"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-019-00740-z"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.038968"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1039\/C9TX00002J"},{"key":"cit0049","first-page":"54","volume":"238","author":"Corcoran GB","year":"1986","journal-title":"J Pharmacol Exp Ther"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198812153192401"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2011.602688"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0667-6_99"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.03.019"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.05.010"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfz077"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.09.005"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1080\/24734306.2019.1705596"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.088898"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.176321"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.01.004"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1692-0"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00325-8"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.07.013"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701311344"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/59.1.169"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.10.185"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl077"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv319"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1885-6"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.09.010"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152464"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13866"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.025"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24690"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.08.020"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.220430497"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086271"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.33162"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.07.006"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400574"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30954"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09046-8"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfw213"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaa041"},{"key":"cit0085","volume-title":"Medicinal plants: classification, biosynthesis and pharmacology","author":"Varela A","edition":"1"},{"key":"cit0086","first-page":"11","volume-title":"Bioactive compounds in plants- benefits and risks for man and animals","author":"Bernhoft A","year":"2010"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8490.89745"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.11.004"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1186\/s12199-017-0662-3"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.65.2555"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-962055"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg220"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.11.009"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.05.023"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00162"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112917"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.06.025"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2019.1676899"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9070594"}],"container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2020.1817896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T07:13:52Z","timestamp":1620458032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2020.1817896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,14]]},"references-count":99,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11,1]]}},"alternative-id":["10.1080\/17425255.2020.1817896"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2020.1817896","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,14]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}