{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:57:50Z","timestamp":1787007470989,"version":"build-2736575974"},"reference-count":114,"publisher":"Informa UK Limited","issue":"8","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"published-print":{"date-parts":[[2024,8,2]]},"DOI":"10.1080\/17425255.2024.2373111","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T09:42:25Z","timestamp":1719394945000},"page":"857-871","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":26,"title":["Investigating in VigiBase over 6000 cases of pneumonia in clozapine-treated patients in the context of the literature: focus on high lethality and the association with aspiration pneumonia"],"prefix":"10.1080","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7756-2314","authenticated-orcid":false,"given":"Jose","family":"de Leon","sequence":"first","affiliation":[{"name":"Eastern State Hospital","place":["Lexington, USA"]},{"name":"University of the Basque Country","place":["Vitoria, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1625-7367","authenticated-orcid":false,"given":"Can-Jun","family":"Ruan","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["Beijing, China"]},{"name":"Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-4117","authenticated-orcid":false,"given":"Georgios","family":"Schoretsanitis","sequence":"additional","affiliation":[{"name":"University of Z\u00fcrich","place":["Z\u00fcrich, Switzerland"]},{"name":"Northwell Health","place":["Glen Oaks, USA"]},{"name":"Zucker School of Medicine at Northwell\/Hofstra","place":["Hempstead, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-8637","authenticated-orcid":false,"given":"Alejandro G.","family":"Villasante-Tezanos","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch","place":["Galveston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2509-7449","authenticated-orcid":false,"given":"Edoardo","family":"Spina","sequence":"additional","affiliation":[{"name":"University of Messina","place":["Messina, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-4435","authenticated-orcid":false,"given":"Emilio J.","family":"Sanz","sequence":"additional","affiliation":[{"name":"Universidad de La Laguna","place":["La Laguna, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7790-8557","authenticated-orcid":false,"given":"Mois\u00e9s","family":"Betancort","sequence":"additional","affiliation":[{"name":"Universidad de La Laguna","place":["La Laguna, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-905X","authenticated-orcid":false,"given":"Carlos","family":"De las Cuevas","sequence":"additional","affiliation":[{"name":"Universidad de La Laguna","place":["La Laguna, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"e_1_3_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-018-3529-4"},{"key":"e_1_3_9_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1581ST"},{"key":"e_1_3_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.21118"},{"key":"e_1_3_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801238-3.11636-8"},{"key":"e_1_3_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2014.04.002"},{"key":"e_1_3_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1714562"},{"key":"e_1_3_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103013440908"},{"key":"e_1_3_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2280"},{"key":"e_1_3_9_11_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2019.43.2.121"},{"key":"e_1_3_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2021.106485"},{"key":"e_1_3_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20994"},{"key":"e_1_3_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13066"},{"key":"e_1_3_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187034"},{"key":"e_1_3_9_16_1","unstructured":"U.S. Food and Drug Administration ed. Public health advisory: deaths with antipsychotics in elderly patients with behavioral disturbances on April 11 2005. [cited 2024 Mar 28]. : Avilable fromhttps:\/\/psychrights.org\/drugs\/FDAantipsychotics4elderlywarning.htm"},{"key":"e_1_3_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2019.1577134"},{"key":"e_1_3_9_18_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0509"},{"key":"e_1_3_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20707"},{"key":"e_1_3_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa163"},{"key":"e_1_3_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2023.2192401"},{"key":"e_1_3_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbz093"},{"key":"e_1_3_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr202"},{"key":"e_1_3_9_24_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12m07938"},{"key":"e_1_3_9_25_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.63246"},{"key":"e_1_3_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-5039-9"},{"key":"e_1_3_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001052"},{"key":"e_1_3_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13142"},{"key":"e_1_3_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13184"},{"key":"e_1_3_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000458"},{"key":"e_1_3_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2017.08.011"},{"key":"e_1_3_9_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/00048674211025707"},{"key":"e_1_3_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2023.06.003"},{"key":"e_1_3_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2023.08.001"},{"key":"e_1_3_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2023.09.029"},{"key":"e_1_3_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12827"},{"key":"e_1_3_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2021.1877135"},{"key":"e_1_3_9_38_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2018.152"},{"key":"e_1_3_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(03)00148-9"},{"key":"e_1_3_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.03.045"},{"key":"e_1_3_9_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506355"},{"key":"e_1_3_9_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091217417749799"},{"key":"e_1_3_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2022.06.001"},{"key":"e_1_3_9_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph13120439"},{"key":"e_1_3_9_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001828"},{"key":"e_1_3_9_46_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.55.5.491"},{"key":"e_1_3_9_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070142"},{"key":"e_1_3_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-022-02314-3"},{"key":"e_1_3_9_49_1","unstructured":"World Health Organization. The WHO Programme for International Drug Monitoring. [cited 2024 Mar 28]. Available from: https:\/\/who-umc.org\/about-the-who-programme-for-international-drug-monitoring\/"},{"key":"e_1_3_9_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098620938595"},{"key":"e_1_3_9_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280211403604"},{"key":"e_1_3_9_52_1","doi-asserted-by":"publisher","DOI":"10.1109\/34.709601"},{"key":"e_1_3_9_53_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_3_9_54_1","first-page":"18","article-title":"Classification and regression by random forest","volume":"2","author":"Liaw A","year":"2002","unstructured":"Liaw A, Wiener M. Classification and regression by random forest. R News. 2002;2:18\u201322.","journal-title":"R News"},{"key":"e_1_3_9_55_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013203451"},{"key":"e_1_3_9_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2022.2122813"},{"key":"e_1_3_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2021.07.004"},{"key":"e_1_3_9_58_1","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2022.0293"},{"key":"e_1_3_9_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001125"},{"key":"e_1_3_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13264"},{"key":"e_1_3_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2023.11.010"},{"key":"e_1_3_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.02.010"},{"key":"e_1_3_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15522"},{"key":"e_1_3_9_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001606"},{"key":"e_1_3_9_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001678"},{"key":"e_1_3_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2023.05.004"},{"key":"e_1_3_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(22)00154-7"},{"key":"e_1_3_9_68_1","unstructured":"US Department of Health and Human Services 2011. Guidance for industry warnings and precautions contraindications and boxed warning sections of labeling for human prescription drug and biological products -content and format. [cited 2024 Mar 28]. Available from: https:\/\/www.fda.gov\/files\/drugs\/published\/Warnings-and-Precautions\u2013Contraindications\u2013and-Boxed-Warning-Sections-of-Labeling-for-Human-Prescription-Drug-and-Biological-Products-%E2%80%94-Content-and-Format.pdf"},{"key":"e_1_3_9_69_1","unstructured":"HLS Therapeutics Inc. CLOZARIL- Clozapine Tablet. HLS Therapeutics (USA) Inc Rosemont PA; 2023 May [cited 2024 Mar 28]. Available from: https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=90876802-0e3a-44c9-9ff7-1754dfbe736a"},{"key":"e_1_3_9_70_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507638"},{"key":"e_1_3_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90305-7"},{"key":"e_1_3_9_72_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770909309054505"},{"key":"e_1_3_9_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199204000-00004"},{"key":"e_1_3_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0270-9139(93)92048-5"},{"key":"e_1_3_9_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2146"},{"key":"e_1_3_9_76_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1288-1061"},{"issue":"8","key":"e_1_3_9_77_1","first-page":"599","article-title":"Clozapine dosages and plasma drug concentrations","volume":"96","author":"Chang WH","year":"1997","unstructured":"Chang WH, Lin SK, Lane HY, et al. Clozapine dosages and plasma drug concentrations. J Formos Med Assoc. 1997;96(8):599\u2013605.","journal-title":"J Formos Med Assoc"},{"key":"e_1_3_9_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199704000-00018"},{"key":"e_1_3_9_79_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1625-6388"},{"key":"e_1_3_9_80_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.22ac14500"},{"key":"e_1_3_9_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15691"},{"key":"e_1_3_9_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-002-0486-x"},{"key":"e_1_3_9_83_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0818a"},{"key":"e_1_3_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2018.07.009"},{"key":"e_1_3_9_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181acd20b"},{"key":"e_1_3_9_86_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048674.2011.572852"},{"key":"e_1_3_9_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht309.P3863"},{"key":"e_1_3_9_88_1","doi-asserted-by":"publisher","DOI":"10.24869\/psyd.2022.411"},{"key":"e_1_3_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2887"},{"key":"e_1_3_9_90_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0417"},{"key":"e_1_3_9_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318218f3e4"},{"key":"e_1_3_9_92_1","unstructured":"UK Medicines and Healthcare Products Regulatory Agency 2020. Clozapine and other antipsychotics: monitoring blood concentrations for toxicity. 2020 Aug 26 [cited 2024 Mar 28]. Available from: https:\/\/www.gov.uk\/drug-safety-update\/clozapine-and-other-antipsychotics-monitoring-blood-concentrations-for-toxicity"},{"key":"e_1_3_9_93_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-116492"},{"key":"e_1_3_9_94_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.19cs13169"},{"key":"e_1_3_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2005.05.002"},{"key":"e_1_3_9_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/pcn5.38"},{"key":"e_1_3_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2022.04.009"},{"key":"e_1_3_9_98_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09301"},{"key":"e_1_3_9_99_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2019.1617695"},{"key":"e_1_3_9_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/appy.12384"},{"key":"e_1_3_9_101_1","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2019-100183"},{"key":"e_1_3_9_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-022-00932-2"},{"key":"e_1_3_9_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011128.pub2"},{"key":"e_1_3_9_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02266-x"},{"key":"e_1_3_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2023.08.004"},{"key":"e_1_3_9_106_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJPSYM.IJPSYM_379_19"},{"key":"e_1_3_9_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-022-00900-w"},{"key":"e_1_3_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2023.09.002"},{"key":"e_1_3_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2023.10.025"},{"key":"e_1_3_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2020.11.002"},{"key":"e_1_3_9_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9695-9"},{"key":"e_1_3_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.12.009"},{"key":"e_1_3_9_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1260915"},{"key":"e_1_3_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41537-023-00412-6"},{"key":"e_1_3_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2024.115810"},{"key":"e_1_3_9_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1366621"}],"container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2024.2373111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:48:35Z","timestamp":1750312115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2024.2373111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,2]]},"references-count":114,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,2]]}},"alternative-id":["10.1080\/17425255.2024.2373111"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2024.2373111","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}