{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:16:02Z","timestamp":1793711762269,"version":"4.6.1"},"reference-count":69,"publisher":"Informa UK Limited","issue":"6","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Bayer Hispania S.L","award":["assistance."],"award-info":[{"award-number":["assistance."]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"published-print":{"date-parts":[[2025,6,3]]},"DOI":"10.1080\/17425255.2025.2478167","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T22:43:51Z","timestamp":1741992231000},"page":"625-636","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["Drug-drug interactions in metastatic hormone-sensitive prostate cancer (mHSPC): practical considerations for treating men with androgen receptor pathway inhibitors and common medications in this stage"],"prefix":"10.1080","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6712-5428","authenticated-orcid":false,"given":"Cristina","family":"Ib\u00e1\u00f1ez","sequence":"first","affiliation":[{"name":"Institut Catal\u00e0 d\u2019Oncologia","place":["Barcelona, Spain"]},{"name":"Universidad Ramon Llull","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7089-3201","authenticated-orcid":false,"given":"Manuel","family":"Tour\u00eds-Lores","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Santiago de Compostela","place":["Santiago de Compostela, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-1250","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Montesa","sequence":"additional","affiliation":[{"name":"Hospital Regional de M\u00e1laga","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-0507","authenticated-orcid":false,"given":"Fernando","family":"L\u00f3pez-Campos","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ram\u00f3n y Cajal","place":["Madrid, Spain"]},{"name":"GenesisCare Vithas La Milagrosa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7938-5033","authenticated-orcid":false,"given":"Emilio","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4323-6634","authenticated-orcid":false,"given":"Paola","family":"Us\u00e1n","sequence":"additional","affiliation":[{"name":"Bayer Hispania S.L","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-5511","authenticated-orcid":false,"given":"Cristina","family":"Moretones","sequence":"additional","affiliation":[{"name":"Bayer Hispania S.L","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-9409","authenticated-orcid":false,"given":"David","family":"Conde-Est\u00e9vez","sequence":"additional","affiliation":[{"name":"Hospital Del Mar","place":["Barcelona, Spain"]},{"name":"Hospital Del Mar Medical Research Institute (IMIM)","place":["Barcelona, Spain"]},{"name":"Universitat Pompeu Fabra","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_3_5_3_1","unstructured":"Ferlay J Ervik M Lam F et al. Global cancer observatory: cancer Today (version 1.1). Lyon (FR): International Agency for Research on Cancer2024. [cited 2024 Oct 25]. Available from: https:\/\/gco.iarc.who.int\/today"},{"key":"e_1_3_5_4_1","unstructured":"National Cancer Institute. SEER. Stat facts: prostate cancer. [cited 2024 Oct 25]. Available from: https:\/\/seer.cancer.gov\/statfacts\/html\/prost.html"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139440"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.01.049"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2403-7"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.04.010"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503747"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.m2022.0294"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23645"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704174"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702900"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00799"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903835"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00193"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903307"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03488"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00367-1"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119115"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2011.000460"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-018-0036-y"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-07962-6"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-019-00674-0"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2007.00815.x"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/10781552241238198"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP38504"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv029"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-679"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70040-7"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2019.04.261"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2019.1705313"},{"key":"e_1_3_5_33_1","unstructured":"Nubeqa (darolutamide). SmPC. [cited 2024 Oct 25]. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/nubeqa-epar-product-information_en.pdf"},{"key":"e_1_3_5_34_1","unstructured":"Xtandi (enzalutamide). SmPC. [cited 2024 Oct 25]. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/xtandi-epar-product-information_en.pdf"},{"key":"e_1_3_5_35_1","unstructured":"Erleada (apalutamide). SmPC. [cited 2024 Oct 25]. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/erleada-epar-product-information_en.pdf"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2024.2328778"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2022.2122812"},{"key":"e_1_3_5_38_1","first-page":"JCO-24","article-title":"Darolutamide in combination with androgen-deprivation therapy in patients with metastatic hormone-sensitive prostate cancer from the phase III ARANOTE trial","author":"Saad F","year":"2024","unstructured":"Saad F, Vjaters E, Shore N, et al. Darolutamide in combination with androgen-deprivation therapy in patients with metastatic hormone-sensitive prostate cancer from the phase III ARANOTE trial. J Clin Oncol. 2024:JCO-24\u201301798.","journal-title":"J Clin Oncol"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.08034.x"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01037-5"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00230-9"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2024.102096"},{"key":"e_1_3_5_43_1","unstructured":"Zytiga (abiraterone). SmPC. [cited 2024 Oct 25]. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/zytiga-epar-product-information_en.pdf"},{"key":"e_1_3_5_44_1","unstructured":"National Health Survey. Ministerio de Sanidad Consumo y Bienestar Social. Gobierno de Espa\u00f1a. 2017 [cited 2024 Oct 25]. Available from: https:\/\/www.mscbs.gob.es\/estadEstudios\/estadisticas\/encuestaNacional\/encuestaNac2017\/ENSE17_MOD1_REL.pdf"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2017.09.002"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.9741"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.108.005454"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192695"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.2497"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvab005"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2023.01.001"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.07.010"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002121"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2023-0814"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.19966"},{"key":"e_1_3_5_56_1","unstructured":"Lexicomp. Drug interactions. Wolters Kluwer clinical drug information. Hudson (OH): Lexi-comp Inc. [cited 2024 Oct 25]. Available from: http:\/\/online.lexi.com"},{"key":"e_1_3_5_57_1","unstructured":"Drugs.com. [cited 2024 Oct 25]. Available from: https:\/\/www.drugs.com"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2024.2353749"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00039"},{"key":"e_1_3_5_60_1","unstructured":"Orgovyx (regurolix) SmPC. [cited 2024 Oct 25]. Available from: https:\/\/ec.europa.eu\/health\/documents\/community-register\/2022\/20220429155430\/anx_155430_en.pdf"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.07.011"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12007"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-014-0262-8"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-03089-x"},{"key":"e_1_3_5_65_1","unstructured":"Memorial Sloan Kettering Cancer Centre. About herbs botanicals & other products. [cited 2024 Oct 25]. Available from: https:\/\/www.mskcc.org\/cancer-care\/diagnosis-treatment\/symptom-management\/integrative-medicine\/herbs"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00177"},{"key":"e_1_3_5_67_1","unstructured":"Natural medicines. [cited 2024 Oct 25]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14050487"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2017-0194"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.18.00086"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01159-y"}],"container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2025.2478167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T09:57:57Z","timestamp":1747994277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2025.2478167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":69,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,3]]}},"alternative-id":["10.1080\/17425255.2025.2478167"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2025.2478167","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}