{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:20:19Z","timestamp":1793661619524,"version":"4.5.1"},"reference-count":120,"publisher":"Informa UK Limited","issue":"6","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"published-print":{"date-parts":[[2025,6,3]]},"DOI":"10.1080\/17425255.2025.2481891","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T07:38:59Z","timestamp":1742456339000},"page":"637-647","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":39,"title":["The influence of female sex and estrogens on drug pharmacokinetics: what is the evidence?"],"prefix":"10.1080","volume":"21","author":[{"given":"E.L.","family":"Bosch","sequence":"first","affiliation":[{"name":"University of Groningen","place":["Groningen, Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.E.C.","family":"Sommer","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen, University of Groningen","place":["Groningen, Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.J.","family":"Touw","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen","place":["Groningen, Netherlands"]},{"name":"University of Groningen","place":["Groningen, Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_3_5_3_1","first-page":"358","article-title":"Gender based medicine","volume":"33","author":"Panetta JA","year":"1998","unstructured":"Panetta JA, Srinivasan U. Gender based medicine. Annu Rep Med Chem. 1998;33:358.","journal-title":"Annu Rep Med Chem"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.3.0467"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.05.014"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.120.000206"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-020-00308-5"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/187103"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-015-0285-2"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000540"},{"key":"e_1_3_5_11_1","volume-title":"Menopause: potential impact on clinical pharmacology and opportunities for future research","author":"FDA Office of Women\u2019s Health","year":"2023","unstructured":"FDA Office of Women\u2019s Health. Menopause: potential impact on clinical pharmacology and opportunities for future research. Webinar: Bringing Clinical Research to Patients; 2023 Oct 11."},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.4414\/SMW.2021.w30025"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.06.047"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2022.106196"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12101342"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.04.069"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90263-8"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90758-0"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpaic.2017.04.007"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-139X(94)90628-9"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310000410"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.650904"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00574"},{"key":"e_1_3_5_24_1","unstructured":"National Library of Medicine [Internet]. Treasure Island (FL): Statpearls Publishing; Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551679\/"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojpsych.2023.133016"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.775"},{"key":"e_1_3_5_27_1","unstructured":"Europe PMC [Internet]. Drug distribution. Available from Treasure Island (FL): Statpearls Publishing; 2021 Feb 25; [cited 2024 July 15]. https:\/\/europepmc.org\/article\/NBK\/nbk567736"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.831179"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802949-7.00008-0"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-023-01126-7"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1990.tb03620.x"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.44.101802.121453"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(90)90108-5"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920013804870709"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801340105"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26196003"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2234"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-021-00587-0"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0071"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.4.4.413"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312808"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02852.x"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-015-0075-x"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n0108"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.08.021"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2000.00128.x"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0389-y"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721004591"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912709922008560"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125319859973"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.031542"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.15.40"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2015.0022"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.32.5.484"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.046276"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-002-0480-3"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327107082224"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07022-9"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200107000-00004"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.054866"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.016568"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00202-9"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01868.x"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2001.01328.x"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.108949"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0835-0"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.065540"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.126174"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200007000-00006"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105053306"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122010627"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-005-0051-5"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50393"},{"key":"e_1_3_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2006.11.001"},{"key":"e_1_3_5_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008323754"},{"key":"e_1_3_5_76_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.053819"},{"key":"e_1_3_5_77_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.128388"},{"key":"e_1_3_5_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)12089-2"},{"key":"e_1_3_5_79_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.002469"},{"key":"e_1_3_5_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12794"},{"key":"e_1_3_5_81_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199834030-00003"},{"key":"e_1_3_5_82_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.110560"},{"key":"e_1_3_5_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1998.tb03147.x"},{"key":"e_1_3_5_84_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000033017.52484.81"},{"key":"e_1_3_5_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-023-00957-1"},{"key":"e_1_3_5_86_1","doi-asserted-by":"publisher","DOI":"10.18433\/J36016"},{"key":"e_1_3_5_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp900077q"},{"key":"e_1_3_5_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2016.08.001"},{"key":"e_1_3_5_89_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-116492"},{"key":"e_1_3_5_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00058.2017"},{"key":"e_1_3_5_91_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.035345"},{"key":"e_1_3_5_92_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.026609"},{"key":"e_1_3_5_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13597"},{"key":"e_1_3_5_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-56637-5_69-1"},{"key":"e_1_3_5_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.05.010"},{"key":"e_1_3_5_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-1126-8"},{"key":"e_1_3_5_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89442-7"},{"key":"e_1_3_5_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002374"},{"key":"e_1_3_5_99_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020020151"},{"key":"e_1_3_5_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl227"},{"key":"e_1_3_5_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-11-20"},{"key":"e_1_3_5_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(97)00502-4"},{"key":"e_1_3_5_103_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP48192"},{"key":"e_1_3_5_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.09.021"},{"key":"e_1_3_5_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-015-0020-3"},{"key":"e_1_3_5_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(01)00305-9"},{"key":"e_1_3_5_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.10105.x"},{"key":"e_1_3_5_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02539.x"},{"key":"e_1_3_5_109_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bd8295"},{"key":"e_1_3_5_110_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000344167.78102.f0"},{"key":"e_1_3_5_111_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WNF.0000220820.78854.3F"},{"key":"e_1_3_5_112_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522070-00001"},{"key":"e_1_3_5_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-017-9795-8"},{"key":"e_1_3_5_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genm.2012.10.003"},{"key":"e_1_3_5_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1150-0"},{"key":"e_1_3_5_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12672"},{"key":"e_1_3_5_117_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000585"},{"key":"e_1_3_5_118_1","doi-asserted-by":"publisher","DOI":"10.1080\/08039488.2017.1314011"},{"key":"e_1_3_5_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000074"},{"key":"e_1_3_5_120_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20020154"},{"key":"e_1_3_5_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107059"},{"key":"e_1_3_5_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-022-01200-8"}],"container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2025.2481891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T13:57:59Z","timestamp":1748008679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2025.2481891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":120,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,3]]}},"alternative-id":["10.1080\/17425255.2025.2481891"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2025.2481891","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,20]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}