{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:20:54Z","timestamp":1793917254867,"version":"4.8.0"},"reference-count":110,"publisher":"Informa UK Limited","issue":"6","license":[{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["178188"],"award-info":[{"award-number":["178188"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"published-print":{"date-parts":[[2025,6,3]]},"DOI":"10.1080\/17425255.2025.2495955","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T13:10:16Z","timestamp":1745154616000},"page":"665-676","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["DILI prediction in drug development: present and future"],"prefix":"10.1080","volume":"21","author":[{"given":"Jack","family":"Uetrecht","sequence":"first","affiliation":[{"name":"University of Toronto","place":["Toronto, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,4,20]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4609"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaf003"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00614-5"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-014-0182-7"},{"key":"e_1_3_5_7_1","volume-title":"Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver","author":"Zimmerman H.","year":"1999","unstructured":"Zimmerman H. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. Philadelphia: Lippincott Williams & Wilkins; 1999."},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14990"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13746"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1465"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518799598"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840020513"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2011.605790"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.16191"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.013"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18160"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000822"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068111"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27912"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaa128"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1375"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx300341r"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.034"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.11.036"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12558"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1201876"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-6-200503210-00121"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.02.019"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2014.04.009"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00547.x"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)24104-0"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26564"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000754"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13424"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1006\/smim.1998.0143"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.120.000090"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.6b00357"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2007.11.014"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(02)00059-5"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207934109"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500458"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4309"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.4c00279"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx980249i"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.7b00025"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010814-124720"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1240008"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx034195a"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200009290-00012"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e32832775fe"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16525"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3838"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.054288"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm218"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.156331"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008617019897"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1086\/428093"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.025"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfae058"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5b00305"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx219"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27549"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5b00137"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402027"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2022.116258"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22400"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-017-2002-1"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c03552"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx034170b"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.027797"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx800161s"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-9556(24)15352-4"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaa088"},{"key":"e_1_3_5_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx800177k"},{"key":"e_1_3_5_75_1","doi-asserted-by":"publisher","DOI":"10.12970\/2308-8044.2020.08.07"},{"key":"e_1_3_5_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2015.08.157"},{"key":"e_1_3_5_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx0200109"},{"key":"e_1_3_5_78_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920021131400114"},{"key":"e_1_3_5_79_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-12-RG-134"},{"key":"e_1_3_5_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.111160"},{"key":"e_1_3_5_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2012.05.007"},{"key":"e_1_3_5_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.12.013"},{"key":"e_1_3_5_83_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2014.939628"},{"key":"e_1_3_5_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.07.038"},{"key":"e_1_3_5_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.9b00116"},{"key":"e_1_3_5_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-00663-0_12"},{"key":"e_1_3_5_87_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510263331702"},{"key":"e_1_3_5_88_1","doi-asserted-by":"publisher","DOI":"10.1086\/430441"},{"key":"e_1_3_5_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq269"},{"key":"e_1_3_5_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1994.tb11143.x"},{"key":"e_1_3_5_91_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1253222"},{"key":"e_1_3_5_92_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.114667"},{"key":"e_1_3_5_93_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9426"},{"key":"e_1_3_5_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1222"},{"key":"e_1_3_5_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx284"},{"key":"e_1_3_5_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-895X(24)13269-5"},{"key":"e_1_3_5_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfab154"},{"key":"e_1_3_5_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.7b00065"},{"key":"e_1_3_5_99_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.45.673"},{"key":"e_1_3_5_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.1c00127"},{"key":"e_1_3_5_101_1","doi-asserted-by":"publisher","DOI":"10.1691\/ph.2022.1955"},{"key":"e_1_3_5_102_1","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.4207770"},{"key":"e_1_3_5_103_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.119.087981"},{"key":"e_1_3_5_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2008.06.011"},{"key":"e_1_3_5_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn109"},{"key":"e_1_3_5_106_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2019.4982"},{"key":"e_1_3_5_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfae054"},{"key":"e_1_3_5_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021243"},{"key":"e_1_3_5_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.19"},{"key":"e_1_3_5_110_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.123.001970"},{"key":"e_1_3_5_111_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfz112"},{"key":"e_1_3_5_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx000139n"}],"container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2025.2495955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T09:57:40Z","timestamp":1747994260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2025.2495955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,20]]},"references-count":110,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,3]]}},"alternative-id":["10.1080\/17425255.2025.2495955"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2025.2495955","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,20]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}