{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:17:02Z","timestamp":1790810222002,"version":"4.1.0"},"reference-count":45,"publisher":"Informa UK Limited","issue":"6","funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Education","award":["NRF-"],"award-info":[{"award-number":["NRF-"]}]},{"name":"KRIBB Research Initiative Program","award":["844"],"award-info":[{"award-number":["844"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanotoxicology"],"published-print":{"date-parts":[[2018,7,3]]},"DOI":"10.1080\/17435390.2018.1472313","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T06:43:18Z","timestamp":1527748998000},"page":"637-651","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":33,"title":["Copper nanoparticles induce early fibrotic changes in the liver via TGF-<b>\u03b2<\/b>\/Smad signaling and cause immunosuppressive effects in rats"],"prefix":"10.1080","volume":"12","author":[{"given":"In-Chul","family":"Lee","sequence":"first","affiliation":[{"name":"Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea;"},{"name":"College of Veterinary Medicine BK21 Plus Team, Chonnam National University, Gwangju, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je-Won","family":"Ko","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine BK21 Plus Team, Chonnam National University, Gwangju, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hyeuk","family":"Park","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine BK21 Plus Team, Chonnam National University, Gwangju, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Rae","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine BK21 Plus Team, Chonnam National University, Gwangju, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Sik","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine BK21 Plus Team, Chonnam National University, Gwangju, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjong","family":"Moon","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine BK21 Plus Team, Chonnam National University, Gwangju, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine BK21 Plus Team, Chonnam National University, Gwangju, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Kee","family":"Yun","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung-Chin","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Choon","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine BK21 Plus Team, Chonnam National University, Gwangju, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2018,5,30]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00159-8"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.05.044"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.04.013"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.10.003"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3392"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.359"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.223"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.01.004"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.06.046"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2000.020003191.x"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2009.08.005"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2014.12.015"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00429-4"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.3390\/coatings4010139"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00292.x"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-5422-8"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2014.12.023"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.13-0045"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1021\/tx800064j"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S106346"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-016-0169-x"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.06.026"},{"issue":"1","key":"CIT0022","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"Lowry O. H.","year":"1951","journal-title":"The Journal of Biological Chemistry"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2011.552124"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2007.09.015"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2013.01.001"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1242\/dev.030338"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114397"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7339"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2015.1078851"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(00)00004-2"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010121308"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1080\/10408391003785417"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2009.0252.focus"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.245"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069534"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.03.012"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2006.00299.x"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-015-0088-2"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020707811707"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.03.050"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.3390\/nano7120441"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-364931-7.50007-0"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-014-2777-4"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1082"}],"container-title":["Nanotoxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17435390.2018.1472313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T19:44:17Z","timestamp":1661370257000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17435390.2018.1472313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,30]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,7,3]]}},"alternative-id":["10.1080\/17435390.2018.1472313"],"URL":"https:\/\/doi.org\/10.1080\/17435390.2018.1472313","relation":{},"ISSN":["1743-5390","1743-5404"],"issn-type":[{"value":"1743-5390","type":"print"},{"value":"1743-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,30]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=inan20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=inan20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}