{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:54:03Z","timestamp":1791428043313,"version":"4.3.3"},"reference-count":51,"publisher":"Informa UK Limited","issue":"3","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanotoxicology"],"published-print":{"date-parts":[[2020,3,15]]},"DOI":"10.1080\/17435390.2020.1718232","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T09:52:16Z","timestamp":1580291536000},"page":"420-432","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":95,"title":["Silicon dioxide and titanium dioxide particles found in human tissues"],"prefix":"10.1080","volume":"14","author":[{"given":"Ruud J. B.","family":"Peters","sequence":"first","affiliation":[{"name":"Wageningen Food Safety Research, Wageningen, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes G.","family":"Oomen","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greet","family":"van Bemmel","sequence":"additional","affiliation":[{"name":"Wageningen Food Safety Research, Wageningen, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loes","family":"van Vliet","sequence":"additional","affiliation":[{"name":"Wageningen Food Safety Research, Wageningen, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Undas","sequence":"additional","affiliation":[{"name":"Wageningen Food Safety Research, Wageningen, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Munniks","sequence":"additional","affiliation":[{"name":"Wageningen Food Safety Research, Wageningen, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L. A. W.","family":"Bleys","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Tromp","sequence":"additional","affiliation":[{"name":"TNO Earth, Life and Social Sciences, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Brand","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"van der Lee","sequence":"additional","affiliation":[{"name":"Wageningen Food Safety Research, Wageningen, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/0026-265X(72)90135-X"},{"key":"CIT0002","first-page":"37","volume-title":"Colloidal Silica: Fundamentals and Applications","author":"Bergna H. E.","year":"2006"},{"issue":"2","key":"CIT0003","first-page":"140","volume":"55","author":"B\u00f6ckmann J.","year":"2000","journal-title":"Pharmazie"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.3109\/17435391003775266"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-092469-4.50011-X"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001206"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph120809282"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2010.519836"},{"key":"CIT0009","unstructured":"EU Official Journal of the European Union. 2008a. Commission Directive 2008\/84\/EC of 27 August 2008 Laying Down Specific Purity Criteria on Food Additive Other Than Colours and Sweeteners.\n                      Official Journal of the European Union\n                      L253."},{"key":"CIT0010","unstructured":"EU Official Journal of the European Union. 2008b. Regulation (Ec) No. 1333\/2008 of the European Parliament and of the Council of 16 December 2008 on Food Additives.\n                      Official Journal of the European Union\n                      L354: 16\u201333."},{"key":"CIT0011","first-page":"13","volume":"237","author":"European Commission","year":"1994","journal-title":"Official Journal of the European Communities"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199605000-00016"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2002.tb00331.x"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.02.001"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2018.5327"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-018-0251-7"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2014.12.005"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1002\/ieam.1571"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1021\/ac402980q"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b00392"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-019-4480-y"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1038\/444267a"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/S0956-7135(02)00059-2"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000000055"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1021\/es7029637"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-7-39"},{"key":"CIT0027","volume-title":"Mineral Tolerance of Animals: Second Revised Edition","author":"National Research Council.","year":"2005"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.3390\/nano9060888"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-015-0101-9"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.36959\/525\/442"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.11.238"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-013-7571-0"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1039\/C4JA00357H"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1021\/jf5011885"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1021\/nn204728k"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2016.1222457"},{"key":"CIT0037","first-page":"127","volume":"9","author":"Ryu H. J.","year":"2014","journal-title":"International Journal of Nanomedicine"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-008-2449-2"},{"key":"CIT0039","unstructured":"Sepeur, S., N. Laryea, S. Goedicke, and F. Grobeta. Hannover: Vincentz Network, 2008."},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-10-15"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b02978"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.2131\/jts.33.293"},{"key":"CIT0043","unstructured":"U.S. Food and Drug Administration. 2002. \u201cCode of Federal Regulations Title 21-Food and Drugs Part 73, Listing of color additives exempt from certification.\u201d 21CFR73.2575."},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-11-8"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2014.940408"},{"key":"CIT0046","unstructured":"Van Rossem, T. M., H. P. Fransen, J. Verkaik-Kloosterman, E. J. M. Buurma-Rethans, and M. C. Ocke. 2011. Dutch National Food Consumption Survey 2007\u20132010. Diet of children and adults 7 to 69 years. RIVM-Report 350050006, Bilthoven; 2011."},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1021\/es204168d"},{"key":"CIT0048","volume-title":"Toxicological Evaluation of Some Food Additives Including Anticaking Agents, Antimicrobials, Antioxidants, Emulsifiers and Thickening Agents","author":"WHO.","year":"1974"},{"key":"CIT0049","volume-title":"Environmental Health Criteria 24: Titanium","author":"WHO.","year":"1982"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2019.5760"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1980.10667459"}],"container-title":["Nanotoxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17435390.2020.1718232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T23:18:12Z","timestamp":1598743092000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17435390.2020.1718232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,29]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3,15]]}},"alternative-id":["10.1080\/17435390.2020.1718232"],"URL":"https:\/\/doi.org\/10.1080\/17435390.2020.1718232","relation":{},"ISSN":["1743-5390","1743-5404"],"issn-type":[{"value":"1743-5390","type":"print"},{"value":"1743-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,29]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=inan20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=inan20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}