{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:56:26Z","timestamp":1780541786540,"version":"3.54.1"},"reference-count":85,"publisher":"Informa UK Limited","funder":[{"name":"Sunway University International Network Grant Scheme","award":["STR-IRNGS-SMLS-CVVR-01-2021"],"award-info":[{"award-number":["STR-IRNGS-SMLS-CVVR-01-2021"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine"],"DOI":"10.1080\/17435889.2024.2372243","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T12:24:55Z","timestamp":1723638295000},"page":"1-21","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Immunogenicity of trivalent DNA vaccine candidate encapsulated in Chitosan-TPP nanoparticles against EV-A71 and CV-A16"],"prefix":"10.1080","author":[{"given":"Jia Sheng","family":"Yew","sequence":"first","affiliation":[{"name":"Centre for Virus &amp; Vaccine Research, School of Medical &amp; Life Sciences, Sunway University, Petaling Jaya, 47500, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng-Kai","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Biological science, School of Medical &amp; Life Sciences, Sunway University, Petaling Jaya, 47500, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Xuan","family":"Lim","sequence":"additional","affiliation":[{"name":"Centre for Virus &amp; Vaccine Research, School of Medical &amp; Life Sciences, Sunway University, Petaling Jaya, 47500, Malaysia"},{"name":"Sunway Microbiome Centre, School of Medical &amp; Life Sciences, Sunway University, Petaling Jaya, 47500, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Hao","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine, Universiti Malaya, Federal Territory of Kuala Lumpur, Kuala Lumpur, 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kien Chai","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine, Universiti Malaya, Federal Territory of Kuala Lumpur, Kuala Lumpur, 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kum Thong","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Universiti Malaya, Federal Territory of Kuala Lumpur, Kuala Lumpur, 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-6291","authenticated-orcid":false,"given":"Chit Laa","family":"Poh","sequence":"additional","affiliation":[{"name":"Centre for Virus &amp; Vaccine Research, School of Medical &amp; Life Sciences, Sunway University, Petaling Jaya, 47500, Malaysia"},{"name":"ALPS Global Holding Berhad, The ICON, No.1, Off Jalan Tun Razak, Kuala Lumpur, 50400, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"e_1_3_9_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.090438"},{"key":"e_1_3_9_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/rwvi.1999.0057"},{"key":"e_1_3_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.55.4.214"},{"key":"e_1_3_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2018.1510326"},{"key":"e_1_3_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2020.170443"},{"key":"e_1_3_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25248"},{"key":"e_1_3_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06157-w"},{"key":"e_1_3_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-45024-6_2"},{"key":"e_1_3_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-016-0465-y"},{"key":"e_1_3_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.02.008"},{"key":"e_1_3_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0094-1"},{"key":"e_1_3_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00980.x"},{"key":"e_1_3_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-019-0698-z"},{"key":"e_1_3_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200801478"},{"key":"e_1_3_9_17_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-010-9391-2"},{"key":"e_1_3_9_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.09.84"},{"key":"e_1_3_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-9632-8_25"},{"key":"e_1_3_9_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652311798192815"},{"key":"e_1_3_9_21_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2014.901308"},{"key":"e_1_3_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0410-5_3"},{"key":"e_1_3_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2006.12.005"},{"key":"e_1_3_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.04.010"},{"key":"e_1_3_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422x-11-79"},{"key":"e_1_3_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.02.051"},{"key":"e_1_3_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10071036"},{"key":"e_1_3_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12050418"},{"issue":"3","key":"e_1_3_9_29_1","first-page":"411","article-title":"Chitin and chitosan: production and application of versatile biomedical nanomaterials","volume":"4","author":"Elieh-Ali-Komi D","year":"2016","unstructured":"Elieh-Ali-Komi D, Hamblin MR. Chitin and chitosan: production and application of versatile biomedical nanomaterials. Inter J Advan Res. 2016;4(3):411\u2013427.","journal-title":"Inter J Advan Res."},{"key":"e_1_3_9_30_1","unstructured":"Kumar A Kumar AJBS Performance Applications et al. Chitosan as a biomedical material: properties and applications. 2017:139\u2013153."},{"key":"e_1_3_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics9040053"},{"key":"e_1_3_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.03.017"},{"key":"e_1_3_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17060381"},{"key":"e_1_3_9_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S54226"},{"key":"e_1_3_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.08.032"},{"key":"e_1_3_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104560"},{"key":"e_1_3_9_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano7110379"},{"key":"e_1_3_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14071443"},{"key":"e_1_3_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano8110920"},{"key":"e_1_3_9_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/IECP2020-08653"},{"key":"e_1_3_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-010-9286-1"},{"key":"e_1_3_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.04.015"},{"key":"e_1_3_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-023-03540-x"},{"key":"e_1_3_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60761-5"},{"key":"e_1_3_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004562"},{"issue":"1","key":"e_1_3_9_46_1","first-page":"240","article-title":"Causative agents of hand, foot and mouth disease in University Malaya Medical Centre, Kuala Lumpur, Malaysia in 2012\u20132013","volume":"34","author":"Aw-Yong KL","year":"2017","unstructured":"Aw-Yong KL, Sam IC, Koh MT, et al. Causative agents of hand, foot and mouth disease in University Malaya Medical Centre, Kuala Lumpur, Malaysia in 2012\u20132013. Tropical Biomed. 2017;34(1):240\u2013248.","journal-title":"Tropical Biomed."},{"key":"e_1_3_9_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00100"},{"key":"e_1_3_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb5020043"},{"key":"e_1_3_9_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0573-2"},{"key":"e_1_3_9_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-0556-5-6"},{"key":"e_1_3_9_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010169"},{"key":"e_1_3_9_52_1","doi-asserted-by":"crossref","unstructured":"Zhang K Fang H Chen Z et al. Shape effects of nanoparticles conjugated with cell-penetrating peptides (HIV Tat PTD) on CHO cell uptake. 2008;19(9):1880\u20131887. doi:10.1021\/bc800160b","DOI":"10.1021\/bc800160b"},{"key":"e_1_3_9_53_1","doi-asserted-by":"crossref","unstructured":"Chithrani BD Ghazani AA Chan WCJNl. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. 2006;6(4):662\u2013668. doi:10.1021\/nl052396o","DOI":"10.1021\/nl052396o"},{"key":"e_1_3_9_54_1","doi-asserted-by":"crossref","unstructured":"Cai Y Lapitsky YJC Biointerfaces SB. Biomolecular uptake effects on chitosan\/tripolyphosphate micro-and nanoparticle stability. 2020;193:111081. doi:10.1016\/j.colsurfb.2020.111081","DOI":"10.1016\/j.colsurfb.2020.111081"},{"key":"e_1_3_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2016.09.050"},{"key":"e_1_3_9_56_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSA.S91785"},{"key":"e_1_3_9_57_1","volume-title":"Development of Hierarchical Magnetic Nanocomposite Materials for Biomedical Applications.","author":"Clarke SP","year":"2013","unstructured":"Clarke SP, editor. Development of Hierarchical Magnetic Nanocomposite Materials for Biomedical Applications. Dublin: Dissertation\/Ph.D, Dublin City University; 2013."},{"key":"e_1_3_9_58_1","doi-asserted-by":"publisher","DOI":"10.18433\/J3TP4T"},{"key":"e_1_3_9_59_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijap.2018v10i5.26375"},{"key":"e_1_3_9_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/13102818.2019.1578690"},{"key":"e_1_3_9_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym11040646"},{"key":"e_1_3_9_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054289"},{"key":"e_1_3_9_63_1","doi-asserted-by":"publisher","DOI":"10.2147\/nano.2006.1.2.117"},{"key":"e_1_3_9_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13050793"},{"key":"e_1_3_9_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-006-9006-x"},{"key":"e_1_3_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.01.083"},{"key":"e_1_3_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(98)00097-2"},{"key":"e_1_3_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00385-9"},{"key":"e_1_3_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.01.016"},{"key":"e_1_3_9_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101686"},{"key":"e_1_3_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.11.066"},{"key":"e_1_3_9_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18055611"},{"key":"e_1_3_9_73_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2016.2134"},{"key":"e_1_3_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00623-3"},{"key":"e_1_3_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00445-3"},{"key":"e_1_3_9_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.880377"},{"key":"e_1_3_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2016.11.001"},{"key":"e_1_3_9_78_1","doi-asserted-by":"publisher","DOI":"10.14302\/issn.2640-6403.jtrr-17-1840"},{"key":"e_1_3_9_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10121534"},{"key":"e_1_3_9_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12824"},{"key":"e_1_3_9_81_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20133126"},{"key":"e_1_3_9_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-016-0178-4"},{"key":"e_1_3_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38348"},{"key":"e_1_3_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.09.058"},{"key":"e_1_3_9_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00847"},{"key":"e_1_3_9_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.155"},{"key":"e_1_3_9_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02905.x"}],"container-title":["Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17435889.2024.2372243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T12:25:05Z","timestamp":1723638305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17435889.2024.2372243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,14]]},"references-count":85,"alternative-id":["10.1080\/17435889.2024.2372243"],"URL":"https:\/\/doi.org\/10.1080\/17435889.2024.2372243","relation":{},"ISSN":["1743-5889","1748-6963"],"issn-type":[{"value":"1743-5889","type":"print"},{"value":"1748-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,14]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}