{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T18:49:22Z","timestamp":1781376562458,"version":"3.54.1"},"reference-count":119,"publisher":"Informa UK Limited","issue":"3","funder":[{"name":"National Institutes of Health National Institute of General Medical Sciences R35 Maximizing Investigators\u2019 Research Award","award":["1R35GM160475-01"],"award-info":[{"award-number":["1R35GM160475-01"]}]},{"DOI":"10.13039\/100007179","name":"University of New Mexico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007179","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UNM Adaptive Design for the Community Fund"},{"name":"UNM Comprehensive Cancer Center American Cancer Society","award":["IRG-21-146-25"],"award-info":[{"award-number":["IRG-21-146-25"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1080\/17435889.2025.2598337","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:42:15Z","timestamp":1765006935000},"page":"409-427","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Emerging nanotechnology-enabled siRNA oral delivery platforms"],"prefix":"10.1080","volume":"21","author":[{"given":"Angelea","family":"Maestas-Olguin","sequence":"first","affiliation":[{"name":"University of New Mexico","place":["Albuquerque, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya M.","family":"Dawson","sequence":"additional","affiliation":[{"name":"University of New Mexico","place":["Albuquerque, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Rhoades","family":"Clark","sequence":"additional","affiliation":[{"name":"University of New Mexico","place":["Albuquerque, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia L.","family":"Lanier","sequence":"additional","affiliation":[{"name":"University of New Mexico","place":["Albuquerque, USA"]},{"name":"University of New Mexico","place":["Albuquerque, USA"]},{"name":"University of New Mexico Comprehensive Cancer Center","place":["Albuquerque, USA"]},{"name":"University of New Mexico","place":["Albuquerque, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"e_1_3_8_2_1","doi-asserted-by":"publisher","DOI":"10.59566\/IJBS.2017.13048"},{"key":"e_1_3_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01925-5"},{"key":"e_1_3_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0207-x"},{"key":"e_1_3_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0591-y"},{"key":"e_1_3_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph13100294"},{"key":"e_1_3_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3978"},{"key":"e_1_3_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07774"},{"key":"e_1_3_8_9_1","unstructured":"Berne & Levy Physiology - ClinicalKey [Internet]. [cited 2025 Aug 17]. Available from: https:\/\/www-clinicalkey-com.libproxy.unm.edu\/#!\/browse\/book\/3-s2.0-C20200000472"},{"key":"e_1_3_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122191"},{"key":"e_1_3_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.12.005"},{"key":"e_1_3_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2021.04.004"},{"key":"e_1_3_8_13_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v7.29759"},{"key":"e_1_3_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.35"},{"key":"e_1_3_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01539-x"},{"key":"e_1_3_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00390-X"},{"key":"e_1_3_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02054"},{"key":"e_1_3_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101332"},{"key":"e_1_3_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-022-03415-7"},{"key":"e_1_3_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02147-z"},{"key":"e_1_3_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"e_1_3_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.01.005"},{"key":"e_1_3_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-328166"},{"key":"e_1_3_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.105812"},{"key":"e_1_3_8_25_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2014.20.2.265"},{"key":"e_1_3_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/35078107"},{"key":"e_1_3_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.08.004"},{"key":"e_1_3_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b05547"},{"key":"e_1_3_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.168039"},{"key":"e_1_3_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-012-0961-8"},{"key":"e_1_3_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.01.033"},{"key":"e_1_3_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18033"},{"key":"e_1_3_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.214"},{"key":"e_1_3_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.55029"},{"key":"e_1_3_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44174-023-00122-8"},{"key":"e_1_3_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b01518"},{"key":"e_1_3_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9704-2"},{"key":"e_1_3_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn500101c"},{"key":"e_1_3_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.03.013"},{"key":"e_1_3_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.3c01223"},{"key":"e_1_3_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5c00445"},{"key":"e_1_3_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-024-01709-4"},{"key":"e_1_3_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.12.010"},{"key":"e_1_3_8_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051686"},{"key":"e_1_3_8_45_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2017-0196"},{"key":"e_1_3_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2024.114588"},{"key":"e_1_3_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.08.021"},{"key":"e_1_3_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1086-4"},{"key":"e_1_3_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc700285q"},{"key":"e_1_3_8_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.5b00538"},{"key":"e_1_3_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.01.079"},{"key":"e_1_3_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.01.061"},{"key":"e_1_3_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.105019"},{"key":"e_1_3_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1478"},{"key":"e_1_3_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2019.102091"},{"key":"e_1_3_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.11.003"},{"key":"e_1_3_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103481"},{"key":"e_1_3_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121680"},{"key":"e_1_3_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.04.017"},{"key":"e_1_3_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202002846"},{"key":"e_1_3_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2016.05.020"},{"key":"e_1_3_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101614"},{"key":"e_1_3_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.07.012"},{"key":"e_1_3_8_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12121188"},{"key":"e_1_3_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpx.2023.100220"},{"key":"e_1_3_8_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00102.2004"},{"key":"e_1_3_8_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm0609691"},{"key":"e_1_3_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.11.002"},{"key":"e_1_3_8_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00466.2010"},{"key":"e_1_3_8_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CP01478J"},{"key":"e_1_3_8_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206821"},{"key":"e_1_3_8_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialsau.3c00032"},{"key":"e_1_3_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.10.002"},{"key":"e_1_3_8_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14091969"},{"key":"e_1_3_8_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189784"},{"key":"e_1_3_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26269"},{"key":"e_1_3_8_77_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.056"},{"key":"e_1_3_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.04.046"},{"key":"e_1_3_8_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp300293n"},{"key":"e_1_3_8_80_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB00967H"},{"key":"e_1_3_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45666-5"},{"key":"e_1_3_8_82_1","doi-asserted-by":"crossref","unstructured":"Mateescu MA Ispas-Szabo P Assaad E. editors. Chitosan and its derivatives as self-assembled systems for drug delivery. Controlled drug delivery [Internet]. Woodhead Publishing; 2015. p. 85\u2013125. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9781907568459000032","DOI":"10.1016\/B978-1-907568-45-9.00003-2"},{"key":"e_1_3_8_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2020.1796628"},{"key":"e_1_3_8_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-025-03890-8"},{"key":"e_1_3_8_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202505955"},{"key":"e_1_3_8_86_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.11.003"},{"key":"e_1_3_8_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2859"},{"key":"e_1_3_8_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01452-1"},{"key":"e_1_3_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.11.009"},{"key":"e_1_3_8_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.3c01704"},{"key":"e_1_3_8_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaa078"},{"key":"e_1_3_8_92_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.2.5.12720"},{"key":"e_1_3_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.05.004"},{"key":"e_1_3_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2024.102437"},{"key":"e_1_3_8_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-020-00208-1"},{"key":"e_1_3_8_96_1","unstructured":"Humira 2025 prices coupons & savings tips - GoodRx. [cited 2025 Sept 13]. Available from: http:\/\/www.goodrx.com\/humira?label_override=humira&form=carton&dosage=2-pens-of-40mg-0.4ml&quantity=1&drugId=42954"},{"key":"e_1_3_8_97_1","unstructured":"Givlarri prescribing info [Internet]. [cited 2025 Nov 20]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2019\/0212194s000lbl.pdf"},{"key":"e_1_3_8_98_1","unstructured":"Amvuttra prescribing info [Internet]. [cited 2025 Nov 20]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/215515s000lbl.pdf"},{"key":"e_1_3_8_99_1","unstructured":"Novartis Pharmaceutical Company. Leqvio\u00ae (inclisiran) injection for subcutaneous use. 2025 [cited 2025 Aug 18]. Available from: https:\/\/www.leqvio.com\/"},{"key":"e_1_3_8_100_1","unstructured":"OXLUMO (lumasiran) Label [Internet]. [cited 2025 Nov 20]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/214103lbl.pdf"},{"key":"e_1_3_8_101_1","unstructured":"Redemplo prescribing info [Internet]. [cited 2025 Nov 20]. Available from: https:\/\/arrowheadpharma.com\/en-us\/redemplo\/prescribing-information.pdf"},{"key":"e_1_3_8_102_1","unstructured":"Arrowhead Pharmaceuticals announces FDA approval of REDEMPLO\u00ae (plozasiran) to reduce triglycerides in adults with familial chylomicronemia syndrome (FCS) [Internet]. Arrowhead Pharmaceuticals Inc. [cited 2025 Nov 20]. Available from: https:\/\/arrowheadpharma.com\/news-press\/arrowhead-pharmaceuticals-announces-fda-approval-of-redemplo-plozasiran-to-reduce-triglycerides-in-adults-with-familial-chylomicronemia-syndrome-fcs\/"},{"key":"e_1_3_8_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy12020058"},{"key":"e_1_3_8_104_1","unstructured":"Ottawa (ON): canadian Agency for Drugs and Technologies in Health. Entyvio (vedolizumab) [Internet]. 2016. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK424368\/"},{"key":"e_1_3_8_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.06.007"},{"key":"e_1_3_8_106_1","unstructured":"Humira [Internet]. GoodRx. [cited 2025 Sep 13]. Available from: https:\/\/www.goodrx.com\/humira?label_override=humira&form=carton&dosage=2-pens-of-40mg-0.4ml&quantity=1&drugId=42954"},{"key":"e_1_3_8_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202401355"},{"key":"e_1_3_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastha.2025.100647"},{"key":"e_1_3_8_109_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318281f4f1"},{"key":"e_1_3_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2023.101754"},{"key":"e_1_3_8_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1393646"},{"key":"e_1_3_8_112_1","unstructured":"ONPATTRO-Prescribing-Information.pdf [Internet]. [cited 2025 Nov 14]. Available from: https:\/\/www.alnylam.com\/sites\/default\/files\/pdfs\/ONPATTRO-Prescribing-Information.pdf"},{"key":"e_1_3_8_113_1","unstructured":"Entyvio (vedolizumab). Internet. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 [cited 2025 Aug 15]. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK424368\/"},{"key":"e_1_3_8_114_1","unstructured":"Onpattro prescribing info [Internet]. [cited 2025 Nov 20]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/210922s000lbl.pdf"},{"key":"e_1_3_8_115_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2024.02.035"},{"key":"e_1_3_8_116_1","unstructured":"Savings & Insurance Information | LEQVIO\u00ae (inclisiran) [Internet]. [cited 2025 Nov 20]. Available from: https:\/\/www.leqvio.com\/savings-and-support\/savings"},{"key":"e_1_3_8_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-017-1918-3"},{"key":"e_1_3_8_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20632-6"},{"key":"e_1_3_8_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2013.2"},{"key":"e_1_3_8_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.08.030"}],"container-title":["Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17435889.2025.2598337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:51:45Z","timestamp":1770018705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17435889.2025.2598337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":119,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1080\/17435889.2025.2598337"],"URL":"https:\/\/doi.org\/10.1080\/17435889.2025.2598337","relation":{},"ISSN":["1743-5889","1748-6963"],"issn-type":[{"value":"1743-5889","type":"print"},{"value":"1748-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}