{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:17:37Z","timestamp":1792549057687,"version":"4.5.0"},"reference-count":119,"publisher":"Informa UK Limited","issue":"7","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5R43AI106112-02"],"award-info":[{"award-number":["5R43AI106112-02"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2017,7,3]]},"DOI":"10.1080\/17460441.2017.1331216","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T03:53:05Z","timestamp":1494906785000},"page":"711-731","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":103,"title":["Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn\u2019s disease"],"prefix":"10.1080","volume":"12","author":[{"given":"Laurel K.","family":"Mydock-McGrane","sequence":"first","affiliation":[{"name":"Fimbrion Therapeutics, Inc., Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Hannan","sequence":"additional","affiliation":[{"name":"Fimbrion Therapeutics, Inc., Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Janetka","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(01)00303-X"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.80.3.331"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2013.09.003"},{"key":"CIT0004","first-page":"587","volume-title":"Urologic diseases in America","author":"Griebling TL","year":"2007"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir345"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00123-06"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.02.009"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1067\/mda.2003.12"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.08.023"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0430"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003081"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2003.04.001"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3013"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00676"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1586\/eri.12.145"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01103-16"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01191-16"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.2.1387-1393.2006"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9630"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084550"},{"issue":"22","key":"CIT0021","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1242\/jcs.114.22.4095","volume":"114","author":"Zhou G","year":"2001","journal-title":"J Cell Sci"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201600018"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700740218"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1038\/265623a0"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/139.3.329"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(82)90947-0"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(83)88019-7"},{"issue":"2","key":"CIT0028","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1128\/IAI.55.2.472-476.1987","volume":"55","author":"Firon N","year":"1987","journal-title":"Infect Immun"},{"issue":"4","key":"CIT0029","first-page":"117","volume":"11","author":"Andrade JRC","year":"1980","journal-title":"Rev Microbiol"},{"issue":"4","key":"CIT0030","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1128\/IAI.52.2.428-436.1986","volume":"52","author":"Neeser J","year":"1986","journal-title":"Infect Immun"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2016.1131266"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1021\/jm101011y"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2010.08.007"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1039\/b009786l"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1021\/jm400723n"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB00424E"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1021\/jm100438s"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1021\/jm501524q"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04415.x"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201200125"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1021\/jm300165m"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-381274-2.00011-X"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.321"},{"issue":"3","key":"CIT0044","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1128\/IAI.54.3.613-620.1986","volume":"54","author":"Hultgren S","year":"1986","journal-title":"Infect Immun"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00948"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201600006"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2010.06.015"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00797.x"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.242"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606795103"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00014-10"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2010.0357"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1601944"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201600066"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10738"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001042"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2012.00339.x"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.116"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308125100"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004599"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00952.x"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003021"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit245"},{"issue":"3","key":"CIT0064","first-page":"231","volume":"40","author":"Keane WF","year":"1967","journal-title":"Yale J Biol Med"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.110"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm464"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30504"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090741"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01298-15"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1038\/356252a0"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01050-4"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1038\/nature12007"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.05.033"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5430.1058"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02915.x"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002040"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902179106"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1007\/128_2008_13"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05352.x"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1021\/bi300251r"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1021\/ml400269v"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1107\/S2052252516016675"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1039\/b610745a"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1021\/jm300192x"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)80654-3"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201402714"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201000774"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.08.057"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12329"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1039\/C4MD00093E"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.9.26"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.03.059"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.461376"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503160112"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2820-8"},{"issue":"2","key":"CIT0096","first-page":"14","volume":"5","author":"Szunerits S","year":"2016","journal-title":"Biology (Basel)"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2016.06.021"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(03)00055-3"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23599"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1107\/S2052252516002487"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1139\/cjc-2015-0582"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01923"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011070425430"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1002\/1439-7633(20020902)3:9<836::AID-CBIC836>3.0.CO;2-2"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1021\/mp200490b"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1039\/C5OB01581B"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b00413"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201204015"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200900034"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1039\/C6PY00118A"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201100515"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006920027641"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1039\/a801985a"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2011.04.023"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr33826f"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc04468g"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200700063"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2016.01.004"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1021\/cr500303t"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2017.1331216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T12:25:06Z","timestamp":1659011106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2017.1331216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":119,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,5,22]]},"published-print":{"date-parts":[[2017,7,3]]}},"alternative-id":["10.1080\/17460441.2017.1331216"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2017.1331216","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}