{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:57:45Z","timestamp":1773449865057,"version":"3.50.1"},"reference-count":87,"publisher":"Informa UK Limited","issue":"7","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2018,7,3]]},"DOI":"10.1080\/17460441.2018.1471056","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T13:18:36Z","timestamp":1525785516000},"page":"617-626","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["A systems biology approach to antimalarial drug discovery"],"prefix":"10.1080","volume":"13","author":[{"given":"Wilian Augusto","family":"Cortopassi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of California, San Francisco (UCSF), San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6048-8103","authenticated-orcid":false,"given":"Tanos","family":"Celmar Costa Franca","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Military Institute of Engineering, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoniana Ursine","family":"Krettli","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Mal\u00e1ria, Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1938.72790360005007"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1323"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21096"},{"key":"CIT0005","first-page":"1)","author":"Berman AY","year":"2017","journal-title":"NPJ Precis Oncol"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2017.09.002"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1038\/srep27239"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.32"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1922"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1038\/4381079a"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1327"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621489114"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.07.001"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004053"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.CR0070042"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1038\/npjsba.2016.34"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005763"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30920"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1086\/524889"},{"key":"CIT0020","unstructured":"World malaria report 2015. World Health Organisation: Geneva, 2015. Available from: http:\/\/www.who.int\/malaria\/publications\/world-malaria-report-2015\/report\/en\/. [cited 2018 April 14]."},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1038\/nm1350"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.12.007"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3073"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3111"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1186\/s40794-016-0027-8"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/1990651103"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16767-6"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00012-6"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2011.10507383"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.15.10213"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10111"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1002\/med.21446"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14097"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1586\/eri.09.68"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-144"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14127"},{"key":"CIT0038","author":"Zaw MT","year":"2017","journal-title":"J Microbiol Immunol Infect"},{"issue":"6","key":"CIT0039","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4269\/ajtmh.2007.77.181","volume":"77","author":"Nosten F","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170830103003"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2017.03.002"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01226-16"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.04.014"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2016-000094"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20160180"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1038\/nature01097"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2006.11.003"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-55"},{"key":"CIT0049","first-page":"5","author":"Pradhan A","year":"2015","journal-title":"Sci Rep"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003257"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1031"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.09.004"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02216-15"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00510-08"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu351"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004710"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1021\/jm200592f"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30171-8"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193225"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4573"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518632112"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1021\/jm3001373"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad9735"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-346-2_7"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-9-r54"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.10.5528"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2010.60"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-4-120"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1614"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005397"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0343-7"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2016.04.011"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3402"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.037"},{"issue":"6","key":"CIT0075","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1111\/j.1365-2958.2007.06009.x","volume":"66","author":"Lopez-Rubio JJ","year":"2007","journal-title":"Mol Microbiol"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609084103"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000084"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.07.004"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001223"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000737"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01238-06"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409024200"},{"key":"CIT0083","first-page":"113(8):1084-92","author":"White NJ","year":"2004","journal-title":"J Clin Invest"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1038\/nature07632"},{"key":"CIT0085","volume":"5","author":"MalariaGEN Plasmodium falciparum Community Project (multiple authors)","year":"2016","journal-title":"Elife"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-6-118"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-6-121"},{"key":"CIT0088","first-page":"15(4):415-21","author":"Tun KM","year":"2015","journal-title":"Lancet Infect Dis"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2018.1471056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T16:15:53Z","timestamp":1720282553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2018.1471056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,8]]},"references-count":87,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,4,19]]},"published-print":{"date-parts":[[2018,7,3]]}},"alternative-id":["10.1080\/17460441.2018.1471056"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2018.1471056","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,8]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}