{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:26:46Z","timestamp":1788258406274,"version":"build-2803163510"},"reference-count":95,"publisher":"Informa UK Limited","issue":"9","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["GM 40375"],"award-info":[{"award-number":["GM 40375"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK044295"],"award-info":[{"award-number":["R01 DK044295"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 ES06841"],"award-info":[{"award-number":["R01 ES06841"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007015","name":"University of Wisconsin-Madison","doi-asserted-by":"publisher","award":["Biomedical Research Support Grant"],"award-info":[{"award-number":["Biomedical Research Support Grant"]}],"id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2018,9,2]]},"DOI":"10.1080\/17460441.2018.1508207","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T09:57:00Z","timestamp":1534154220000},"page":"815-824","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":17,"title":["Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design"],"prefix":"10.1080","volume":"13","author":[{"given":"Xin-Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan A.","family":"Elfarra","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences and the Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2468"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003459"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.10.061"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.06.013"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00521K"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.08.014"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22205"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2017.08.002"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-014-9638-z"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00013"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2011.09.001"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2010.01.003"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1080\/10408360500523878"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.6.718"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2013"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2016.07.013"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-005-0243-4"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0552-0"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1177\/44.10.8813074"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-420117-0.00003-7"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60229-4"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199609193351207"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-004-0466-0"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu259"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-013-1033-3"},{"key":"CIT0027","first-page":"3609","volume":"32","author":"Dormoy V","year":"2012","journal-title":"Anticancer Res"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1159\/000355906"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.08.004"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2014.04.003"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2012.695347"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0090-9556(25)06667-X","volume":"23","author":"Lash LH","year":"1995","journal-title":"Drug Metab Dispos"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/53.2.458"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s2177"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1080\/009841099158204"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s2225"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(90)90319-P"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(86)90527-7"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1021\/tx900219x"},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1016\/S0021-9258(17)38472-7","volume":"261","author":"Lash LH","year":"1986","journal-title":"J Biol Chem"},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0026-895X(25)10356-8","volume":"31","author":"Elfarra AA","year":"1987","journal-title":"Mol Pharmacol"},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1016\/S0021-9258(19)39303-2","volume":"265","author":"Sausen PJ","year":"1990","journal-title":"J Biol Chem"},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0026-895X(24)13493-1","volume":"51","author":"Ripp SL","year":"1997","journal-title":"Mol Pharmacol"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.042911"},{"key":"CIT0045","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0022-3565(25)38701-X","volume":"269","author":"Lash LH","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1021\/tx00024a010"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1021\/tx200263n"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1021\/tx800060z"},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0022-3565(25)20828-X","volume":"251","author":"Hwang IY","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/S0022-3565(25)10645-9","volume":"274","author":"Elfarra AA","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0022-3565(25)20373-1","volume":"258","author":"Hwang IY","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0090-9556(25)08171-1","volume":"21","author":"Elfarra AA","year":"1993","journal-title":"Drug Metab Dispos"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)00401-2"},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0022-3565(25)10284-X","volume":"264","author":"Hwang IY","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00177-X"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2009.033"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00196"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1038\/nature07733"},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/S0022-3565(24)34992-4","volume":"290","author":"Gunnarsdottir S","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.1.77"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.32.3.321"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.02.002"},{"key":"CIT0063","first-page":"1211","volume":"1","author":"Gunnarsdottir S","year":"2002","journal-title":"Mol Cancer Ther"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1517\/17425250903427980"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-015-2920-7"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.08.010"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1021\/jm060022h"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-052845"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.174904"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1021\/ja412380j"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1039\/C6BM00800C"},{"key":"CIT0072","first-page":"409","volume":"2","author":"Shami PJ","year":"2003","journal-title":"Mol Cancer Ther"},{"key":"CIT0073","first-page":"173","volume":"32","author":"Watanabe A","year":"1978","journal-title":"Acta Med Okayama"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000197"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1038\/nm0302-282"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2016.00021"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-548800"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2016.81.030791"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.11.019"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2803"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1038\/nature10167"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14844"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1038\/nature10189"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1038\/nature08268"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209373"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2015.1136259"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3137"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.225"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.08.009"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2017.1344757"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1038\/nature12634"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4201"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2018.1508207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T09:31:38Z","timestamp":1751794298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2018.1508207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,13]]},"references-count":95,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,8,20]]},"published-print":{"date-parts":[[2018,9,2]]}},"alternative-id":["10.1080\/17460441.2018.1508207"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2018.1508207","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,13]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}