{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:26:54Z","timestamp":1790515614851,"version":"4.1.0"},"reference-count":87,"publisher":"Informa UK Limited","issue":"3","funder":[{"name":"not funded"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2019,3,4]]},"DOI":"10.1080\/17460441.2019.1567487","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T12:11:01Z","timestamp":1549282261000},"page":"199-220","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":27,"title":["Successes, failures, and future prospects of prodrugs and their clinical impact"],"prefix":"10.1080","volume":"14","author":[{"given":"Anas","family":"Najjar","sequence":"first","affiliation":[{"name":"Department of Bioorganic & Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Quds University, Jerusalem, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafik","family":"Karaman","sequence":"additional","affiliation":[{"name":"Department of Bioorganic & Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Quds University, Jerusalem, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"key":"CIT0001","volume-title":"Prodrugs design: a new era","author":"Karaman R.","year":"2014"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2010.09.014"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2014.954545"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061289"},{"issue":"10","key":"CIT0005","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22101736","volume":"22","author":"Sinokrot H","year":"2017","journal-title":"Molecules"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170201161037"},{"key":"CIT0007","first-page":"11","volume":"1","author":"Karaman R","year":"2014","journal-title":"Drug Discovery"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1038\/182421a0"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13051156"},{"issue":"7","key":"CIT0010","first-page":"503","volume":"90","author":"Armstrong C","year":"2014","journal-title":"Am Fam Physician"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004675"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.3317\/jraas.2000.002"},{"issue":"9","key":"CIT0013","first-page":"609","volume":"17","author":"Vegter S","year":"2011","journal-title":"Am J Manag Care"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12800"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00250-2"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.115.068536"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.9398"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S78145"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003589"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-017-0259-7"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S6714"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1080\/10245330310001621260"},{"issue":"20","key":"CIT0023","first-page":"4733","volume":"21","author":"Spartalis M","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-014-0230-6"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.3390\/jpm8030022"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1545-1"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.2165\/11208400-000000000-00000"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.2165\/11208320-000000000-00000"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.rinphs.2014.04.002"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0848-4"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1097\/chi.0b013e318054e724"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.2165\/11634340-000000000-00000"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-3-377"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1517\/17425250903228842"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199141040-00009"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.10.053"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199914050-00006"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.2217\/imt.10.52"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12048"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.032151"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2016.1254191"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2010.513970"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2019.1553954"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2018.1417388"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00729-09"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh244"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/bs.podrm.2017.12.001"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1058774"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A393"},{"issue":"2","key":"CIT0050","first-page":"ii5","volume":"65","author":"Davies BE","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02728.x"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.2165\/11635560-000000000-00000"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0247-z"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214853"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60247-0"},{"issue":"5","key":"CIT0056","first-page":"457","volume":"59","author":"Craig WA","year":"1983","journal-title":"Bull N Y Acad Med"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.13.1.90"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1039\/9781849731102-00099"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.7.1085"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.03.004"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1519021"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199936050-00004"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2017.1290080"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2018.02.005"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2018.02.002"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.05.036"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D283"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464200-00004"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.037663"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.03.003"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1159\/000220703"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01880.x"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6142"},{"issue":"6","key":"CIT0075","first-page":"862","volume":"21","author":"Janssen PA","year":"1971","journal-title":"Arzneimittel-Forschung"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2015.033"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.16.6.855"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29081"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.3101"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.11000"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S140638"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000386"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1021\/jm701028q"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2709-z"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30381-9"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.114.062893"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000469"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2017.0366"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2019.1567487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T10:31:55Z","timestamp":1662892315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2019.1567487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,4]]},"references-count":87,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,1,11]]},"published-print":{"date-parts":[[2019,3,4]]}},"alternative-id":["10.1080\/17460441.2019.1567487"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2019.1567487","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}