{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:50:27Z","timestamp":1790059827835,"version":"4.0.1"},"reference-count":131,"publisher":"Informa UK Limited","issue":"9","license":[{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006501","name":"Cystic Fibrosis Foundation Therapeutics","doi-asserted-by":"publisher","award":["DICK17XX00"],"award-info":[{"award-number":["DICK17XX00"]}],"id":[{"id":"10.13039\/100006501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI132374"],"award-info":[{"award-number":["R01AI132374"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2019,9,2]]},"DOI":"10.1080\/17460441.2019.1629414","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T07:37:18Z","timestamp":1560497838000},"page":"867-878","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":62,"title":["Repositioning rifamycins for Mycobacterium abscessus lung disease"],"prefix":"10.1080","volume":"14","author":[{"given":"Uday S.","family":"Ganapathy","sequence":"first","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Dartois","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-9452","authenticated-orcid":false,"given":"Thomas","family":"Dick","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-814692-7.00001-2"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1546751"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-93473-0_7"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1159\/000445906"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201503-173OC"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.3201\/eid2303.161827"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.02.013"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201606-474BC"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02448-14"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02179"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01613"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-93473-0_13"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01427-17"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw466"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx284"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx125"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00119-18"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01275-08"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201501-015OI"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq237"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.110957"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0395OC"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2014.10.004"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0778OC"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1444"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.04.001"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201810-1901ED"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1318OC"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1273PP"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhealeco.2016.01.012"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1060"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02266-17"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3283511a64"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4273"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/5.Supplement_3.S402"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1159\/000220462"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1038\/207417a0"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(67)90147-5"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1021\/bi00657a029"},{"issue":"5","key":"CIT0042","first-page":"523","volume":"17","author":"Arioli V","year":"1967","journal-title":"Arzneimittelforschung"},{"issue":"5","key":"CIT0043","first-page":"529","volume":"17","author":"Pallanza R","year":"1967","journal-title":"Arzneimittelforschung"},{"issue":"2","key":"CIT0044","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1128\/JB.97.2.761-768.1969","volume":"97","author":"Lancini G","year":"1969","journal-title":"J Bacteriol"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.3109\/03602538109011084"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku457"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3937"},{"issue":"10","key":"CIT0048","first-page":"S231","volume":"3","author":"Fox W","year":"1999","journal-title":"Int J Tuberc Lung Dis"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr154"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/419392"},{"issue":"9","key":"CIT0051","first-page":"544","volume":"26","author":"Sha W","year":"2003","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.92.5s1.7.x"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.000333"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1994.tb07194.x"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14220"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02123"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005660"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06003-11"},{"key":"CIT0059","first-page":"81","volume":"374","author":"Szumowski JD","year":"2013","journal-title":"Curr Top Microbiol Immunol"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711939105"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.01.009"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2012.04.001"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1651494"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00155-17"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00623-18"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.10.013"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1660472"},{"issue":"1","key":"CIT0068","volume":"22","author":"Blaschke TF","year":"1996","journal-title":"Clin Infect Dis"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/22.2.185"},{"issue":"2","key":"CIT0070","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1164\/ajrccm.156.2.atsstatement","volume":"156","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(97)00071-9"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(99)00089-7"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.747952"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.11.0068"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.09.023"},{"issue":"1","key":"CIT0076","volume":"22","author":"Kunin CM","year":"1996","journal-title":"Clin Infect Dis"},{"issue":"3","key":"CIT0077","first-page":"547","volume":"17","author":"Buss WC","year":"1977","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2014.02.001"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402358111"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01166-12"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1038\/nature22308"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00283-18"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02234-18"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01353-17"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt410"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12405"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02613-18"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03112-15"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku062"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00274-17"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02752-16"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01915-18"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00032-13"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00171"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg512"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000021"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000031"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.09.010"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104819"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.10.006"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3200"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424563112"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1038\/nature13967"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01019-18"},{"issue":"3","key":"CIT0105","first-page":"262","volume":"34","author":"Imaoka M","year":"1986","journal-title":"Chemotherapy"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir184"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1080\/004982500237839"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3703"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.4333\/KPS.2006.36.3.157"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06587-2"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.08.028"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00286-0"},{"key":"CIT0113","first-page":"699","volume":"6","author":"Sensi P","year":"1966","journal-title":"Antimicrob Agents Chemother (Bethesda)"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2006.10.016"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.4.738"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1021\/ja307803m"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1998.tb13040.x"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00947"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.12.14"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00179-11"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.160185"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.022"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01102-2015"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201508-1586IM"},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.1.117"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00100"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit614"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00459-15"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01539"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201200428"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.03.001"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0437-z"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tandfonline.com\/doi\/pdf\/10.1080\/17460441.2019.1629414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2019.1629414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T10:07:44Z","timestamp":1589882864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2019.1629414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,14]]},"references-count":131,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9,2]]}},"alternative-id":["10.1080\/17460441.2019.1629414"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2019.1629414","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,14]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}