{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:32:41Z","timestamp":1790098361054,"version":"4.0.1"},"reference-count":175,"publisher":"Informa UK Limited","issue":"11","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2019,11,2]]},"DOI":"10.1080\/17460441.2019.1651289","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T17:42:31Z","timestamp":1566495751000},"page":"1175-1197","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":149,"title":["Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery"],"prefix":"10.1080","volume":"14","author":[{"given":"Alessio","family":"Nocentini","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child\u2019s Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child\u2019s Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.737323"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160115"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1122001"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3554"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2017.1253677"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2013.795145"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1002\/med.21497"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2019.1567488"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2018.1548608"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1523897"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-019-0426-8"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.780598"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2012.649006"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.794788"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.782394"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.790957"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1519023"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1066675"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2016.1154534"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1113407"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1508453"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.798648"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.11.014"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(03)00029-5"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.03.032"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200701189"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1021\/jm030912m"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.09.040"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00334"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc33415a"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC09568J"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1021\/jm801386n"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.12.023"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4261"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1021\/jm101541x"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.422"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.550"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc02707c"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.03.026"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.02.027"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2016.1193009"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1217857"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01607"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00420"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2017-0223"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.2174\/138161208783877857"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600830603"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0854-2"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.03.009"},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/FBP.0000000000000400","volume":"29","author":"Sanku RKK","year":"2018","journal-title":"Behav Pharmacol"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-013-9833-4"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2012.698264"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.742065"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2011.11.017"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004714007457"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201503748"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc34275h"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc16395k"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1021\/jm300031j"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00462"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1021\/jm400414j"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.01.113"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC06399C"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1473379"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1021\/bi702385k"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC08562E"},{"key":"CIT0071","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/chem.201805039","volume":"25","author":"Nocentini A","year":"2019","journal-title":"Chemistry"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC05755A"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13589"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.24.10949"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161301298"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310809200"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908301106"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22144"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.07.051"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1002\/bip.22456"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1021\/bi050610h"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1021\/bi0120446"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.02.038"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22411"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.10.103"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1021\/jm9900523"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(99)00022-6"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1021\/jm9901879"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.3109\/14756369909030336"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.01.096"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1021\/jm990479+"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1405263"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1021\/jm0109199"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/523210"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00770"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.04.016"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.06.022"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1021\/jm501798g"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1021\/jm060967z"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.10.068"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1344236"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1021\/ja00087a086"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805353200"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.01.077"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.06.013"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.09.028"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1512597"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21121649"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1021\/jm1003667"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1021\/jm301625s"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01720"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.629198"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201800941"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.05.032"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.01.043"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.01.076"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00523"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1115401"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1316720"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2018.04.009"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1021\/ja809683v"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1021\/jm901287j"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1021\/jm901524f"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1021\/jm200983e"},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.650692"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2013.777334"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.06.040"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.10.094"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.11.018"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2014.970185"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.07.021"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.09.041"},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1113173"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC07320G"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.4172\/2169-0138.1000e101"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-816545-4.00012-8"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.10.036"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.04.046"},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.597749"},{"key":"CIT0140","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.12.058"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00625"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201310709"},{"key":"CIT0143","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-3457"},{"key":"CIT0144","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b13361"},{"key":"CIT0145","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00139"},{"key":"CIT0146","doi-asserted-by":"publisher","DOI":"10.1021\/cb1003477"},{"key":"CIT0147","doi-asserted-by":"publisher","DOI":"10.3390\/metabo7030048"},{"key":"CIT0148","doi-asserted-by":"publisher","DOI":"10.3390\/metabo8020025"},{"key":"CIT0149","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.92928"},{"key":"CIT0150","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.05.004"},{"key":"CIT0151","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-18-0657"},{"key":"CIT0152","doi-asserted-by":"publisher","DOI":"10.1021\/bi970760v"},{"key":"CIT0153","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200600159"},{"key":"CIT0154","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.08.069"},{"key":"CIT0155","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2006.07.021"},{"key":"CIT0156","doi-asserted-by":"publisher","DOI":"10.1021\/jm0603320"},{"key":"CIT0157","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.08.043"},{"key":"CIT0158","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2006.11.027"},{"key":"CIT0159","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(00)00102-1"},{"key":"CIT0160","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(99)00086-X"},{"key":"CIT0161","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(99)00227-8"},{"key":"CIT0162","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(99)00310-8"},{"key":"CIT0163","doi-asserted-by":"publisher","DOI":"10.3109\/14756360009040703"},{"key":"CIT0164","doi-asserted-by":"publisher","DOI":"10.1080\/14756360009030347"},{"key":"CIT0165","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.06.030"},{"key":"CIT0166","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.07.005"},{"key":"CIT0167","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC02346C"},{"key":"CIT0168","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1308928"},{"key":"CIT0169","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00934"},{"key":"CIT0170","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00623"},{"key":"CIT0171","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14779"},{"key":"CIT0172","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2019.1611801"},{"key":"CIT0173","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1499628"},{"key":"CIT0174","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1461097"},{"key":"CIT0175","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2014.963072"},{"key":"CIT0176","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc40858b"},{"key":"CIT0177","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11071002"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2019.1651289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T10:46:47Z","timestamp":1695120407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2019.1651289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,22]]},"references-count":175,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,7,8]]},"published-print":{"date-parts":[[2019,11,2]]}},"alternative-id":["10.1080\/17460441.2019.1651289"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2019.1651289","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,22]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}