{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:30:09Z","timestamp":1773973809727,"version":"3.50.1"},"reference-count":58,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2020,1,2]]},"DOI":"10.1080\/17460441.2020.1691165","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T09:30:47Z","timestamp":1574242247000},"page":"53-62","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":13,"title":["Cheminformatics and virtual screening studies of COMT inhibitors as potential Parkinson\u2019s disease therapeutics"],"prefix":"10.1080","volume":"15","author":[{"given":"Kalliopi","family":"Moschovou","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Melagraki","sequence":"additional","affiliation":[{"name":"Division of Physical Sciences &amp; Applications, Hellenic Military Academy, Vari, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-992X","authenticated-orcid":false,"given":"Thomas","family":"Mavromoustakos","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lefteris C.","family":"Zacharia","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antreas","family":"Afantitis","sequence":"additional","affiliation":[{"name":"Department of Cheminformatics, NovaMechanics Ltd, Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0021-9258(18)64731-3","volume":"233","author":"Axelrod J","year":"1958","journal-title":"J Biol Chem"},{"key":"CIT0002","first-page":"135","volume":"27","author":"Guldberg HC","year":"1975","journal-title":"Pharmacol Rev"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1021\/bi00013a008"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.tb19083.x"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1177\/42.8.8027527"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1021\/jp207177p"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-8969-7_5"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2007.00020.x"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1969.tb00526.x"},{"issue":"804","key":"CIT0011","first-page":"3","volume":"21","author":"Bonifacio MJ","year":"2007","journal-title":"Faseb J"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1995.tb05781.x"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-381326-8.00007-7"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20011105)40:21<4040::AID-ANIE4040>3.0.CO;2-C"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3765(20000317)6:6<971::AID-CHEM971>3.0.CO;2-0"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1038\/368354a0"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.04.040"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.4.795"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1021\/ja971019d"},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1016\/S0021-9258(19)70536-5","volume":"255","author":"Woodard RW","year":"1980","journal-title":"J Biol Chem"},{"key":"CIT0021","first-page":"238","volume":"42","author":"Vidgren J","year":"1997","journal-title":"Adv Pharmacol"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1021\/bi00384a042"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1021\/ja9827447"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1021\/ja992218v"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.2.393"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.01.024"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.3109\/0954898X.2016.1146416"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1021\/jp410296s"},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0021-9258(17)42348-9","volume":"269","author":"Zhu BT","year":"1994","journal-title":"J. Biol. Chem"},{"key":"CIT0030","first-page":"221","volume":"7","author":"Nagappan P","year":"2015","journal-title":"Int J Pharm Clin Res"},{"key":"CIT0031","first-page":"1","volume":"2","author":"Monteiro A","year":"2018","journal-title":"Hindawi Oxid Med Cell Longevity"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.3.250"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2003.920604.x"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.023119"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1021\/jm040848o"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.5012\/bkcs.2007.28.3.379"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200400084"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1021\/tx025569n"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200904410"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201003648"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-015-1472-z"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1021\/jf800416j"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi208"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.02.110"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.04.004"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.06.025"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.11.085"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1021\/jm1001524"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.22926"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC00221E"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00138"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170102145257"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2017.1404931"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1007\/BF01276562"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120404"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.12.007"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(96)02242-5"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-199406000-00012"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1007\/BF01285556"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2020.1691165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T09:03:53Z","timestamp":1612429433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2020.1691165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,20]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,2]]}},"alternative-id":["10.1080\/17460441.2020.1691165"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2020.1691165","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,20]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}