{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T01:20:04Z","timestamp":1770945604007,"version":"3.50.1"},"reference-count":204,"publisher":"Informa UK Limited","issue":"4","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2020,4,2]]},"DOI":"10.1080\/17460441.2020.1722639","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T03:09:46Z","timestamp":1581563386000},"page":"487-498","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["An overview of drug discovery efforts for eczema: why is this itch so difficult to scratch?"],"prefix":"10.1080","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6682-5529","authenticated-orcid":false,"given":"Kam Lun","family":"Hon","sequence":"first","affiliation":[{"name":"Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital","place":["Shatin, Hong Kong"]},{"name":"The Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong","place":["Shatin, Hong Kong"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Loo","sequence":"additional","affiliation":[{"name":"The Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong","place":["Shatin, Hong Kong"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2254-6971","authenticated-orcid":false,"given":"Alexander K. C.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Calgary, Alberta Children\u2019s Hospital","place":["Calgary, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce T. S.","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Learning Enhancement And Research, The Chinese University of Hong Kong","place":["Shatin, Hong Kong"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5802-8899","authenticated-orcid":false,"given":"Vivian W. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Centre for Learning Enhancement And Research, The Chinese University of Hong Kong","place":["Shatin, Hong Kong"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"e_1_3_4_3_1","first-page":"1","volume-title":"Atopic dermatitis : a review for the primary care physicia. Atopic dermatitis: a review for the primary care physician","author":"Leung AK","year":"2011","unstructured":"Leung AK, Hon KL. Atopic dermatitis : a review for the primary care physicia. Atopic dermatitis: a review for the primary care physician. Hauppauge, N.Y.: Nova Science Publishers; 2011. p. 1\u2013113."},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02849989"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2007.03.013"},{"key":"e_1_3_4_6_1","first-page":"96","article-title":"Clinical guidelines on management of atopic dermatitis in children","volume":"18","author":"Leung TN","year":"2013","unstructured":"Leung TN, Chow CM, Chow MP, et al. Clinical guidelines on management of atopic dermatitis in children. Hong Kong J Paediatr. 2013;18:96\u2013104.","journal-title":"Hong Kong J Paediatr"},{"key":"e_1_3_4_7_1","first-page":"10","article-title":"Eczema therapeutics in children: what do the clinical trials say?","volume":"21","author":"Leung TN","year":"2015","unstructured":"Leung TN, Hon KL. Eczema therapeutics in children: what do the clinical trials say? Hong Kong Med J. 2015;21:10.","journal-title":"Hong Kong Med J"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.04.034"},{"key":"e_1_3_4_9_1","first-page":"354","article-title":"Prevalence of asthma and allergy in Hong Kong schoolchildren: an ISAAC study","volume":"10","author":"Leung R","year":"1997","unstructured":"Leung R, Wong G, Lau J, et al. Prevalence of asthma and allergy in Hong Kong schoolchildren: an ISAAC study. Eur. 1997;10:354\u2013360.","journal-title":"Eur"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61385-3"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903512156"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.251"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-64804-0_3"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2005.03.005"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323290"},{"key":"e_1_3_4_16_1","first-page":"10","article-title":"Intestinal dysbiosis featuring abundance of ruminococcus gnavus associates with allergic diseases in infants","volume":"11","author":"Chua HH","year":"2017","unstructured":"Chua HH, Chou HC, Tung YL, et al. Intestinal dysbiosis featuring abundance of ruminococcus gnavus associates with allergic diseases in infants. Gastroenterol. 2017;11:10.","journal-title":"Gastroenterol"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14205"},{"key":"e_1_3_4_18_1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.47102\/annals-acadmedsg.V34N10p602","article-title":"Clinical features associated with nasal Staphylococcus aureus colonisation in Chinese children with moderate-to-severe atopic dermatitis","volume":"34","author":"Hon KL","year":"2005","unstructured":"Hon KL, Lam MCAC, Leung TFF, et al. Clinical features associated with nasal Staphylococcus aureus colonisation in Chinese children with moderate-to-severe atopic dermatitis. Ann Acad Med Singapore. 2005;34:602\u2013605.","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22020291"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.133"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02326.x"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.05.004"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.280"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-008-0293-z"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1619"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.07.026"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2020"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2009.00859.x"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2232"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.008"},{"key":"e_1_3_4_32_1","article-title":"Circulating immunoglobulins, leucocytes and complements in childhood-onset atopic eczema","volume":"80","author":"Hon KL","year":"2012","unstructured":"Hon KL, Wang SS, Pong NH, et al. Circulating immunoglobulins, leucocytes and complements in childhood-onset atopic eczema. Indian J Pediatr. 2012;80:128\u2013131.","journal-title":"Indian J Pediatr"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212547"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.11.005"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.10.032"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.04.004"},{"key":"e_1_3_4_37_1","article-title":"Atopic dermatitis: a review of evolving targeted therapies","volume":"15","author":"Kalamaha K","year":"2018","unstructured":"Kalamaha K, Reis E, Newton S, et al. Atopic dermatitis: a review of evolving targeted therapies. Expert Rev Clin Immunol. 2018;15:275\u2013288.","journal-title":"Expert Rev Clin Immunol"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15335"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212530"},{"key":"e_1_3_4_40_1","first-page":"417","article-title":"Patient acceptability, efficacy, and skin biophysiology of a cream and cleanser containing lipid complex with shea butter extract versus a ceramide product for eczema","volume":"21","author":"Hon KL","year":"2015","unstructured":"Hon KL, Tsang YC, Pong NH, et al. Patient acceptability, efficacy, and skin biophysiology of a cream and cleanser containing lipid complex with shea butter extract versus a ceramide product for eczema. Hong Kong Med J. 2015;21:417\u2013425.","journal-title":"Hong Kong Med J"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.049"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00837.x"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2003.20617.x"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-018-2687-z"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2018.1494723"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1872213X11666171128142333"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-012-0369-x"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000072"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124617"},{"key":"e_1_3_4_50_1","first-page":"359","article-title":"Inside out or outside in: does atopic dermatitis disrupt barrier function or does disruption of barrier function trigger atopic dermatitis?","volume":"96","author":"Silverberg NB","year":"2015","unstructured":"Silverberg NB, Silverberg JI. Inside out or outside in: does atopic dermatitis disrupt barrier function or does disruption of barrier function trigger atopic dermatitis? Cutis. 2015;96:359\u2013361.","journal-title":"Cutis."},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.029"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82887"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.2177\/jsci.37.160"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.027"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0033-9"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0433-9"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-013-0004-x"},{"key":"e_1_3_4_58_1","first-page":"1","article-title":"Use of ceramides and related products for childhood-onset eczema","volume":"7","author":"Hon KL","year":"2012","unstructured":"Hon KL, Leung AK. Use of ceramides and related products for childhood-onset eczema. Recent Pat Inflamm Allergy Drug Discovery. 2012;7:1.","journal-title":"Recent Pat Inflamm Allergy Drug Discovery"},{"key":"e_1_3_4_59_1","first-page":"132","article-title":"Pseudoceramide for childhood eczema: does it work?","volume":"17","author":"Hon KL","year":"2011","unstructured":"Hon KL, Wang SS, Lau Z, et al. Pseudoceramide for childhood eczema: does it work? Hong Kong Med J. 2011 ;17:132\u2013136.","journal-title":"Hong Kong Med J"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10395.x"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12211"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12185"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03341.x"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0184-3"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12111"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02850199"},{"key":"e_1_3_4_67_1","first-page":"415","article-title":"2% Crisaborole topical ointment for the treatment of mild-to-moderate atopic dermatitis","volume":"13","author":"Cheape AC","year":"2017","unstructured":"Cheape AC, Murrell DF. 2% Crisaborole topical ointment for the treatment of mild-to-moderate atopic dermatitis. Expert. 2017;13:415\u2013423.","journal-title":"Expert"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.05.046"},{"key":"e_1_3_4_69_1","first-page":"172","article-title":"Post hoc analyses of the effect of crisaborole topical ointment, 2% on atopic dermatitis: associated pruritus from phase 1 and 2 clinical studies","volume":"15","author":"Draelos ZD","year":"2016","unstructured":"Draelos ZD, Stein Gold LF, Murrell DF, et al. Post hoc analyses of the effect of crisaborole topical ointment, 2% on atopic dermatitis: associated pruritus from phase 1 and 2 clinical studies. J Drugs Dermatol. 2016 ;15:172\u2013176.","journal-title":"J Drugs Dermatol"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2016-0023"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12780"},{"key":"e_1_3_4_72_1","first-page":"1394","article-title":"A phase 2, randomized, controlled, dose-ranging study evaluating crisaborole topical ointment, 0.5% and 2% in adolescents with mild to moderate atopic dermatitis","volume":"14","author":"Stein Gold LF","year":"2015","unstructured":"Stein Gold LF, Spelman L, Spellman MC, et al. A phase 2, randomized, controlled, dose-ranging study evaluating crisaborole topical ointment, 0.5% and 2% in adolescents with mild to moderate atopic dermatitis. J Drugs Dermatol. 2015;14:1394\u20131399.","journal-title":"J Drugs Dermatol"},{"key":"e_1_3_4_73_1","first-page":"1108","article-title":"Crisaborole topical ointment, 2% in adults with atopic dermatitis: a phase 2a, vehicle-controlled, proof-of-concept study","volume":"14","author":"Murrell DF","year":"2015","unstructured":"Murrell DF, Gebauer K, Spelman L, et al. Crisaborole topical ointment, 2% in adults with atopic dermatitis: a phase 2a, vehicle-controlled, proof-of-concept study. J Drugs Dermatol. 2015;14:1108\u20131112.","journal-title":"J Drugs Dermatol"},{"key":"e_1_3_4_74_1","first-page":"1","article-title":"Oral small molecules for the treatment of atopic dermatitis: a systematic review","author":"Mobasher P","year":"2018","unstructured":"Mobasher P, Heydari Seradj M, Raffi J, et al. Oral small molecules for the treatment of atopic dermatitis: a systematic review. J Dermatolog Treat [Internet]. 2018;1\u20138. [cited 2019 Jan 14]. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30501539","journal-title":"J Dermatolog Treat"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.04.001"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14871"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2217"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1067669"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12184"},{"key":"e_1_3_4_80_1","article-title":"New and emerging targeted systemic therapies: a new era for atopic dermatitis","volume":"19","author":"Lee DE","year":"2017","unstructured":"Lee DE, Clark AK, Tran KA, et al. New and emerging targeted systemic therapies: a new era for atopic dermatitis. J Dermatol Treat. 2017;19:1\u201311.","journal-title":"J Dermatol Treat"},{"key":"e_1_3_4_81_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02342","article-title":"Targeting the Janus kinase family in autoimmune skin diseases","volume":"10","author":"Howell M","year":"2019","unstructured":"Howell M, Kuo F, Smith P. Targeting the Janus kinase family in autoimmune skin diseases. Front Immunol. 2019;10:2342.","journal-title":"Front Immunol"},{"key":"e_1_3_4_82_1","first-page":"1657","article-title":"The anti-IL-4 receptor alpha antibody dupilumab: facing a new era in treating atopic dermatitis","volume":"15","author":"Tsianakas A","year":"2015","unstructured":"Tsianakas A, Luger TA. The anti-IL-4 receptor alpha antibody dupilumab: facing a new era in treating atopic dermatitis. Expert. 2015;15:1657\u20131660.","journal-title":"Expert"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.04.054"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610020"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.15.69"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.10.043"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00388-8"},{"key":"e_1_3_4_88_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nrd.2017.90","article-title":"FDA approves dupilumab for severe eczema","volume":"16","author":"Mullard A","year":"2017","unstructured":"Mullard A. FDA approves dupilumab for severe eczema. Nat Rev Drug Discov. 2017;16:305.","journal-title":"Nat Rev Drug Discov"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606490"},{"key":"e_1_3_4_90_1","first-page":"549","article-title":"New era of biologic therapeutics in atopic dermatitis","volume":"13","author":"Guttman-Yassky E","year":"2013","unstructured":"Guttman-Yassky E, Dhingra N, Leung DY. New era of biologic therapeutics in atopic dermatitis. Expert. 2013 ;13:549\u2013561.","journal-title":"Expert"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700818"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006480200"},{"key":"e_1_3_4_93_1","first-page":"1","article-title":"The effect of 4% sodium cromoglicate cutaneous emulsion compared to vehicle in atopic dermatitis in children\u2013A meta-analysis of total SCORAD scores","volume":"26","author":"Stevens MT","year":"2014","unstructured":"Stevens MT, Edwards AM. The effect of 4% sodium cromoglicate cutaneous emulsion compared to vehicle in atopic dermatitis in children\u2013A meta-analysis of total SCORAD scores. J Dermatol Treat. 2014;26:1\u20137.","journal-title":"J Dermatol Treat"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.08.034"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00762.x"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.34.427"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.024"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.05.007"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12967"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0498-5"},{"key":"e_1_3_4_101_1","first-page":"E789","article-title":"Vitamin D status and efficacy of vitamin D supplementation in atopic dermatitis: a systematic review and meta-analysis","volume":"8","author":"Kim MJ","year":"2016","unstructured":"Kim MJ, Kim SN, Lee YW, et al. Vitamin D status and efficacy of vitamin D supplementation in atopic dermatitis: a systematic review and meta-analysis. Nutr. 2016;8:E789.","journal-title":"Nutr"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2016.01.023"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.3092"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-6-17"},{"key":"e_1_3_4_105_1","first-page":"72","article-title":"Clinical study on treatment of acute eczema by Shuangfujin","volume":"27","author":"Bai YP","year":"2007","unstructured":"Bai YP, Yang DQ, Wang YM. Clinical study on treatment of acute eczema by Shuangfujin. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27:72\u201375.Chinese.","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.132.285"},{"key":"e_1_3_4_107_1","doi-asserted-by":"publisher","DOI":"10.1159\/000318861"},{"issue":"8812","key":"e_1_3_4_108_1","first-page":"188","article-title":"Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis","volume":"340","author":"Sheehan MP","year":"1992","unstructured":"Sheehan MP, Rustin MH, Atherton DJ, et al. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. Erratum Appears Lancet. 1992 Jul 18;340(8812):188. Note: Harris DJ [corrected to Harris DW]]. Lancet. 1992;340:13\u201371.","journal-title":"Erratum Appears Lancet"},{"key":"e_1_3_4_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb07817.x"},{"key":"e_1_3_4_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb03383.x"},{"key":"e_1_3_4_111_1","first-page":"136","article-title":"Follow-up of adult patients with atopic eczema treated with Chinese herbal therapy for 1 year","volume":"20","author":"Sheehan MP","year":"1995","unstructured":"Sheehan MP, Stevens H, Ostlere LS, et al. Follow-up of adult patients with atopic eczema treated with Chinese herbal therapy for 1 year. Clin Exp. 1995;20:136\u2013140.","journal-title":"Clin Exp"},{"key":"e_1_3_4_112_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00732.x"},{"key":"e_1_3_4_113_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X04002545"},{"key":"e_1_3_4_114_1","doi-asserted-by":"crossref","unstructured":"Hon KL Kung JS Tsang KY et al. Do we need another symptom score for childhood eczema?. 2018 Jan 31:1\u20135.","DOI":"10.1080\/09546634.2017.1373734"},{"key":"e_1_3_4_115_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245677"},{"key":"e_1_3_4_116_1","first-page":"23","article-title":"Consensus report of the European task force on atopic dermatitis","volume":"186","author":"Severity scoring of atopic dermatitis: the SCORAD index","year":"1993","unstructured":"Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European task force on atopic dermatitis. Dermatology. 1993;186:23\u201331..","journal-title":"Dermatology"},{"key":"e_1_3_4_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02853.x"},{"key":"e_1_3_4_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-006-0019-7"},{"key":"e_1_3_4_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07941.x"},{"key":"e_1_3_4_120_1","first-page":"755","article-title":"Corticosteroids are not present in a traditional Chinese medicine formulation for atopic dermatitis in children","volume":"35","author":"Hon KL","year":"2006","unstructured":"Hon KL, Lee VW, Leung TF, et al. Corticosteroids are not present in a traditional Chinese medicine formulation for atopic dermatitis in children. Ann Acad Med Singapore. 2006;35:755\u2013759.","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_3_4_121_1","first-page":"77","article-title":"A traditional Chinese medicine capsule for atopic dermatitis in children: an open-label trial","volume":"151","author":"Hon KL","year":"2004","unstructured":"Hon KL, Leung TF, Wong Y, et al. A traditional Chinese medicine capsule for atopic dermatitis in children: an open-label trial. Br J Dermatol Suppl. 2004;151(Supple):77.","journal-title":"Br J Dermatol Suppl"},{"key":"e_1_3_4_122_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2008.0162"},{"key":"e_1_3_4_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.017"},{"key":"e_1_3_4_124_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05471.x"},{"key":"e_1_3_4_125_1","doi-asserted-by":"crossref","unstructured":"Zhang W Leonard T Bath-Hextall F et al. Chinese herbal medicine for atopic eczema. Cochrane Database Syst Rev. 2005;(2):CD002291.","DOI":"10.1002\/14651858.CD002291.pub2"},{"key":"e_1_3_4_126_1","first-page":"573","article-title":"What\u2019s new in atopic eczema? An analysis of systematic reviews published in 2009\u20132010","volume":"36","author":"Shams K","year":"2011","unstructured":"Shams K, Grindlay DJ, Williams HC. What\u2019s new in atopic eczema? An analysis of systematic reviews published in 2009\u20132010. ClinExpDermatol. 2011;36:573\u2013577.","journal-title":"ClinExpDermatol"},{"key":"e_1_3_4_127_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2016.1214673"},{"key":"e_1_3_4_128_1","article-title":"Chinese herbal medicine for atopic eczema","volume":"9","author":"Gu S","year":"2013","unstructured":"Gu S, Yang AW, Xue CC, et al. Chinese herbal medicine for atopic eczema. Cochrane Database Syst Rev. 2013;9:CD008642.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_129_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360526"},{"key":"e_1_3_4_130_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.23469.x"},{"key":"e_1_3_4_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.023"},{"key":"e_1_3_4_132_1","article-title":"Cupping therapy may be harmful for eczema: a pubmed search","volume":"2013","author":"Hon KL","year":"2013","unstructured":"Hon KL, Luk DC, Leong KF, et al. Cupping therapy may be harmful for eczema: a pubmed search. Case Rep Pediatr. 2013;2013:60582:605829.","journal-title":"Case Rep Pediatr"},{"key":"e_1_3_4_133_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2003.01619.x"},{"key":"e_1_3_4_134_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2019.1583204"},{"key":"e_1_3_4_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.023"},{"key":"e_1_3_4_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.10.032"},{"key":"e_1_3_4_137_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000376"},{"key":"e_1_3_4_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13679"},{"key":"e_1_3_4_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.040"},{"key":"e_1_3_4_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.02.064"},{"key":"e_1_3_4_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.05.049"},{"key":"e_1_3_4_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.012"},{"key":"e_1_3_4_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.02.008"},{"key":"e_1_3_4_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.046"},{"key":"e_1_3_4_145_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15913"},{"key":"e_1_3_4_146_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2019.4.24006"},{"key":"e_1_3_4_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2018.05.010"},{"key":"e_1_3_4_148_1","doi-asserted-by":"publisher","DOI":"10.2174\/187221310791163116"},{"key":"e_1_3_4_149_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2010.514893"},{"key":"e_1_3_4_150_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0374"},{"key":"e_1_3_4_151_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00495.x"},{"key":"e_1_3_4_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05776.x"},{"key":"e_1_3_4_153_1","first-page":"369","article-title":"Relationship between quality of life and disease severity in atopic dermatitis\/eczema syndrome during childhood.","volume":"3","author":"BenGashir MA","year":"2003","unstructured":"BenGashir MA. Relationship between quality of life and disease severity in atopic dermatitis\/eczema syndrome during childhood. Curr Allergy Clin. 2003;3:369\u2013373.","journal-title":"Curr Allergy Clin"},{"key":"e_1_3_4_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.01.016"},{"key":"e_1_3_4_155_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001678"},{"key":"e_1_3_4_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.01.007"},{"key":"e_1_3_4_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12727"},{"key":"e_1_3_4_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.12.001"},{"key":"e_1_3_4_159_1","doi-asserted-by":"publisher","DOI":"10.1586\/14789450.2013.814881"},{"key":"e_1_3_4_160_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2014.967684"},{"key":"e_1_3_4_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.059"},{"key":"e_1_3_4_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1401"},{"key":"e_1_3_4_163_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax2945"},{"key":"e_1_3_4_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.08.006"},{"key":"e_1_3_4_165_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071665"},{"key":"e_1_3_4_166_1","first-page":"1264","article-title":"Sleep disturbance of atopic dermatitis","volume":"121","author":"Nocturnal Itch ET","year":"2003","unstructured":"Nocturnal Itch ET. Sleep disturbance of atopic dermatitis. J Invest. 2003;121:1264.","journal-title":"J Invest"},{"key":"e_1_3_4_167_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14660"},{"key":"e_1_3_4_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.02.007"},{"key":"e_1_3_4_169_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08502.x"},{"key":"e_1_3_4_170_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3105"},{"key":"e_1_3_4_171_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04019.x"},{"key":"e_1_3_4_172_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2013.2242"},{"key":"e_1_3_4_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02480-0"},{"key":"e_1_3_4_174_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.873762"},{"key":"e_1_3_4_175_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-64804-0_12"},{"key":"e_1_3_4_176_1","doi-asserted-by":"publisher","DOI":"10.1089\/ped.2016.0702"},{"key":"e_1_3_4_177_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831030-00001"},{"key":"e_1_3_4_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61381-6"},{"key":"e_1_3_4_179_1","first-page":"2","article-title":"Black box warning for topical calcineurin inhibitors and the death of common sense","volume":"12","author":"Fleischer AB","year":"2006","unstructured":"Fleischer AB Jr. Black box warning for topical calcineurin inhibitors and the death of common sense. Dermatol Online J. 2006;12:2.","journal-title":"Dermatol Online J"},{"key":"e_1_3_4_180_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166026"},{"key":"e_1_3_4_181_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12866"},{"key":"e_1_3_4_182_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141067"},{"issue":"15","key":"e_1_3_4_183_1","article-title":"Skin microbiota and atopic dermatitis: toward new therapeutic options?","volume":"142","author":"Lacour JP","year":"2015","unstructured":"Lacour JP. Skin microbiota and atopic dermatitis: toward new therapeutic options? Ann Dermatol Venereol. 2015;142(Suppl(15)142 Suppl 1:S18-22.","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_3_4_184_1","first-page":"679","article-title":"Randomized trial of \u201cbleach baths\u201d plus routine hygienic measures vs. routine hygienic measures alone for prevention of recurrent infections","volume":"58","author":"Kaplan SL","year":"2014","unstructured":"Kaplan SL, Forbes A, Hammerman WA, et al. Randomized trial of \u201cbleach baths\u201d plus routine hygienic measures vs. routine hygienic measures alone for prevention of recurrent infections. ClinInfectDis. 2014;58:679\u2013682.","journal-title":"ClinInfectDis"},{"key":"e_1_3_4_185_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.58"},{"key":"e_1_3_4_186_1","first-page":"160","article-title":"Fecal transplantation - the new, inexpensive, safe, and rapidly effective approach in the treatment of gastrointestinal tract diseases","volume":"9","author":"Oprita R","year":"2016","unstructured":"Oprita R, Bratu M, Oprita B, et al. Fecal transplantation - the new, inexpensive, safe, and rapidly effective approach in the treatment of gastrointestinal tract diseases. J Med Life . 2016;9:160\u2013162.","journal-title":"J Med Life"},{"key":"e_1_3_4_187_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08836.x"},{"key":"e_1_3_4_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2008.09.017"},{"key":"e_1_3_4_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.437"},{"key":"e_1_3_4_190_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.86955"},{"key":"e_1_3_4_191_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah4680"},{"key":"e_1_3_4_192_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120608"},{"key":"e_1_3_4_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.006"},{"key":"e_1_3_4_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05114-X"},{"key":"e_1_3_4_195_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01748.x"},{"key":"e_1_3_4_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(98)00046-2"},{"key":"e_1_3_4_197_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13205"},{"key":"e_1_3_4_198_1","unstructured":"Phototherapy. National eczema association. 2019 [cited 2020 Jan 2]. Available from: https:\/\/nationaleczema.org\/eczema\/treatment\/phototherapy\/"},{"key":"e_1_3_4_199_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X05002904"},{"key":"e_1_3_4_200_1","first-page":"755","article-title":"Corticosteroids are not present in a traditional chinese medicine formulation for atopic dermatitis in children","volume":"35","author":"Hon KL","unstructured":"Hon KL, Lee VW, Leung TF, et al. Corticosteroids are not present in a traditional chinese medicine formulation for atopic dermatitis in children. Ann Acad Med Singapore 2006;35:755\u2013759.","journal-title":"Ann Acad Med Singapore 2006"},{"key":"e_1_3_4_201_1","doi-asserted-by":"publisher","DOI":"10.1515\/jib-2017-0030"},{"key":"e_1_3_4_202_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15122796"},{"key":"e_1_3_4_203_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-040617-014208"},{"key":"e_1_3_4_204_1","doi-asserted-by":"publisher","DOI":"10.4274\/balkanmedj.2017.0966"},{"key":"e_1_3_4_205_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.2017.36.1.3"},{"key":"e_1_3_4_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2018.03.013"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2020.1722639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:41:41Z","timestamp":1770943301000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2020.1722639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,13]]},"references-count":204,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4,2]]}},"alternative-id":["10.1080\/17460441.2020.1722639"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2020.1722639","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,13]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}