{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:22:50Z","timestamp":1790997770062,"version":"4.1.0"},"reference-count":132,"publisher":"Informa UK Limited","issue":"6","funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2016\/21171-6 and 2018\/18954-4"],"award-info":[{"award-number":["2016\/21171-6 and 2018\/18954-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2020,6,2]]},"DOI":"10.1080\/17460441.2020.1743674","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T13:59:41Z","timestamp":1584971981000},"page":"647-658","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":14,"title":["The preclinical discovery and development of oral miltefosine for the treatment of visceral leishmaniasis: a case history"],"prefix":"10.1080","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4418-0838","authenticated-orcid":false,"given":"Juliana Q.","family":"Reim\u00e3o","sequence":"first","affiliation":[{"name":"Departamento de Morfologia e Patologia B\u00e1sica, Faculdade de Medicina de Jundia\u00ed, Jundia\u00ed, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9132-0813","authenticated-orcid":false,"given":"D\u00e9bora P.","family":"Pita Pedro","sequence":"additional","affiliation":[{"name":"Departamento de Morfologia e Patologia B\u00e1sica, Faculdade de Medicina de Jundia\u00ed, Jundia\u00ed, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0659-6269","authenticated-orcid":false,"given":"Adriano C.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Animal, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,3,23]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S146521"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67629-5"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31204-2"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007173"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.973850"},{"key":"cit0007","unstructured":"World Health Organization. Neglected tropical diseases: Global Health Observatory (GHO) data; 2018. Leishmaniasis interactive graph; 2019. [cited 2019 Jul 23]. Available from: https:\/\/www.who.int\/gho\/neglected_diseases\/leishmaniasis\/en\/"},{"key":"cit0008","unstructured":"Pan American Health Organization. Leishmaniasis: epidemiological Report in the Americas. Washington: Pan American Health Organization; 2019 [cited 2019 Jul 23]. Available from: www.paho.org\/leishmaniasis"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182016002523"},{"key":"cit0010","unstructured":"World Health Organization Control of the Leishmaniasis: report of a meeting of the WHO Expert Committee on the Control of Leishmaniases. 2010 [cited 2019 Jul 23]. Available from: https:\/\/apps.who.int\/iris\/handle\/10665\/44412"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.31729\/jnma.2444"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2001.00778.x"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1086\/519690"},{"key":"cit0014","unstructured":"Administration US-FaD. Miltefosine approval letter (ref ID 3473184); 2004 [cited 2020 Jan 18]. Available from: http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2014\/204684Orig1s000Approv.pdf"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(88)90336-7"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.2174\/1389200023337225"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.02.016"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/0305-7372(87)90023-5"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535557"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535558"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535556"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535544"},{"issue":"6","key":"cit0023","first-page":"295","volume":"11","author":"Unger C","year":"1988","journal-title":"Onkologie"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1007\/BF01211805"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.21.4150"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2006.03.009"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)89020-X"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.2307\/3280147"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(82)90042-1"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(87)90080-6"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90543-0"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.8.1630"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.3.654"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)04367-0"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1872-1875.2001"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(99)90192-X"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004660"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002999"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(01)00197-8"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003556"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv495"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01694-08"},{"issue":"3","key":"cit0043","first-page":"656","volume":"96","author":"Espada CR","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.272"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3323-0"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006082"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912093412403"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1999.11813462"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021556"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1086\/380638"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100220"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.4.9.1209"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1007\/BF02763048"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0661"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1086\/505217"},{"issue":"9","key":"cit0056","first-page":"1530","volume":"68","author":"Mbui J","year":"2019","journal-title":"Clin Infect Dis"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.09.029"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03635.x"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks275"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2006.01.002"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.81.209"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00014-08"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001436"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.4.2.177"},{"key":"cit0065","unstructured":"IMPAVIDO - Full prescribing information. 2014 [cited 2020 Jan 18]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2014\/204684s000lbl.pdf"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-015-4684-8"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2006.02.010"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1177\/2049936116646063"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.18.8596"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)90135-X"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000066877.72624.cb"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01123-06"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(02)00220-7"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2012.01.005"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.3390\/proteomes3040328"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-014-7772-1"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2013.11.002"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.03.006"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01415-06"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh380"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02095-17"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.2677-2686.2005"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp321"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(02)00280-3"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(03)00193-6"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1042\/bj3120411"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308352200"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605214200"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2006.04.001"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.8.2397-2403.2003"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2019.02.005"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012443"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05653.x"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00587-08"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.9.2468-2474.2001"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001512"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2015.05.006"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13344-6"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-014-3755-6"},{"key":"cit0100","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13291"},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154101"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.05.007"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.75.1074"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0721"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.80.580"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit102"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1086\/510588"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.10-0060"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07872.x"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.3201\/eid1804.110841"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001657"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005641"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0096"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.18-0949"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu039"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis474"},{"key":"cit0117","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.916614"},{"key":"cit0118","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-1969-z"},{"key":"cit0119","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00611-13"},{"issue":"5","key":"cit0120","first-page":"733","volume":"3","author":"Sundar S","year":"2007","journal-title":"Ther Clin Risk Manag"},{"key":"cit0121","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004093"},{"key":"cit0122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006052"},{"key":"cit0123","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70011-6"},{"key":"cit0124","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62050-8"},{"key":"cit0125","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2004.07.002"},{"key":"cit0126","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005635"},{"key":"cit0127","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.73-79.2006"},{"key":"cit0128","doi-asserted-by":"publisher","DOI":"10.1086\/591972"},{"key":"cit0129","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2009.02306.x"},{"key":"cit0130","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005459"},{"key":"cit0131","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006988"},{"key":"cit0132","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182017002116"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2020.1743674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T02:17:44Z","timestamp":1620440264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2020.1743674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,23]]},"references-count":132,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6,2]]}},"alternative-id":["10.1080\/17460441.2020.1743674"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2020.1743674","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,23]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}