{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:05:52Z","timestamp":1779296752333,"version":"3.51.4"},"reference-count":201,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2023,2,1]]},"DOI":"10.1080\/17460441.2022.2117296","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T07:47:13Z","timestamp":1661413633000},"page":"163-179","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["The discovery and development of RNA-based therapies for treatment of HIV-1 infection"],"prefix":"10.1080","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1253-5806","authenticated-orcid":false,"given":"Michelle J","family":"Chen","sequence":"first","affiliation":[{"name":"Lady Davis Institute for Medical Research, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Division of Experimental Medicine, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4553-0836","authenticated-orcid":false,"given":"Anne","family":"Gatignol","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Division of Experimental Medicine, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Microbiology and Immunology, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7724-2441","authenticated-orcid":false,"given":"Robert J.","family":"Scarborough","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Microbiology and Immunology, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f2dbe7"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1684\/vir.2022.0930"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005201"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1080\/13550280600748946"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0026-6"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00102-15"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31917-7"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70021-6"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32990-3"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000111"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00465"},{"issue":"5","key":"cit0012","first-page":"e01386","volume":"95","author":"Akiyama H","year":"2020","journal-title":"J Virol"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07753-2"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05899-7"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa657"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01590-5"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1027-4"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802905"},{"issue":"1","key":"cit0019","first-page":"23","volume":"30","author":"Hsu JM","year":"2022","journal-title":"Top Antiv Med"},{"issue":"3","key":"cit0020","first-page":"1","volume":"23","author":"Scarborough RJ","year":"2019","journal-title":"Virologie (Montrouge)"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-014-0242-8"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.628137"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1124\/pr.120.019554"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00283-5"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01574-5"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01348-0"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.11.018"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2019.090"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003574"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114432"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.199"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2432-5_3"},{"issue":"1","key":"cit0033","first-page":"20","volume":"15","author":"Zhang X","year":"2018","journal-title":"Retrotopgy"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.02.004"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.05.032"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.3390\/genes3030344"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1515\/jib-2019-0027"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90414-7"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90117-4"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5481.878"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2432-5_5"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1126\/science.2107573"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(91)90016-F"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(98)00046-7"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.21.4059"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1089\/oli.1.1998.8.441"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.9.1161"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26730"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-018-0055-9"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084168"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2017.1414131"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102142"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioeng.2007.06.001"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.003555"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2019.04.003"},{"issue":"3","key":"cit0056","first-page":"193","volume":"11","author":"Byun J","year":"2021","journal-title":"Life (Basel)"},{"key":"cit0057","first-page":"49","volume":"33","author":"Puttaraju M","year":"1995","journal-title":"Nucleic Acids Symp Ser"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.19.3733"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.2.319"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2018.06.001"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6521"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02626-09"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0667"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1261\/rna.077008.120"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.01.013"},{"issue":"10","key":"cit0066","first-page":"2166","volume":"14","author":"Rose KM","year":"2019","journal-title":"ACS Chem Biol"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25720-1"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2015.1"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.23.12692-12698.2003"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.08.025"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01502-08"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06893-11"},{"key":"cit0073","first-page":"408","volume":"7","author":"Mufhandu HT","year":"2016","journal-title":"Biochem Biophys Rep"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp185"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.92"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.226"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001581"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1038\/35888"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064921"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065329"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065062"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1038\/35078107"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.171251798"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq846"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1038\/srep23989"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400509"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102513"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00801-8"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00759-1"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-311-4_4"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn584"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1051"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.72"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt200"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1261\/rna.031120.111"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00949-15"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0017-4"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.5196"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.18.9225-9231.2002"},{"key":"cit0100","doi-asserted-by":"publisher","DOI":"10.1038\/nature00896"},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.1038\/nm725"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302099"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.12963-12973.2002"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.1089\/088922203322280928"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200212060-00002"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.13.7174-7181.2003"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45876"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.034"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.207"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.271"},{"key":"cit0111","first-page":"3637","volume":"7","author":"Miele E","year":"2012","journal-title":"Int J Nanomedicine"},{"key":"cit0112","first-page":"1","volume":"3","author":"Byun MJ","year":"2022","journal-title":"Biochip J"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.03.001"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc7031"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1932"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000931"},{"key":"cit0117","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.1.368.413a47_368_371"},{"key":"cit0118","doi-asserted-by":"publisher","DOI":"10.1038\/mtm.2013.11"},{"key":"cit0119","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2019.02.006"},{"key":"cit0120","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1998.9.16-2407"},{"key":"cit0121","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.705"},{"key":"cit0122","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950017239"},{"key":"cit0123","doi-asserted-by":"publisher","DOI":"10.1089\/104303404322886101"},{"key":"cit0124","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1281.008"},{"key":"cit0125","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.3.1432-1441.1992"},{"key":"cit0126","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.22.10802"},{"key":"cit0127","doi-asserted-by":"publisher","DOI":"10.1089\/oli.2008.0150"},{"key":"cit0128","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.54"},{"key":"cit0129","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1998.9.9-1283"},{"key":"cit0130","doi-asserted-by":"publisher","DOI":"10.1089\/oli.1.1996.6.17"},{"key":"cit0131","doi-asserted-by":"publisher","DOI":"10.4161\/rna.8.2.15200"},{"key":"cit0132","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2014.31"},{"key":"cit0133","doi-asserted-by":"publisher","DOI":"10.1017\/S1355838202020289"},{"key":"cit0134","doi-asserted-by":"publisher","DOI":"10.1089\/108729000421439"},{"key":"cit0135","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2022.01.012"},{"key":"cit0136","doi-asserted-by":"publisher","DOI":"10.1038\/s41434-021-00271-9"},{"key":"cit0137","doi-asserted-by":"publisher","DOI":"10.1038\/srep06242"},{"key":"cit0138","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx155"},{"key":"cit0139","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.158"},{"key":"cit0140","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0716-9_14"},{"key":"cit0141","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212229599"},{"key":"cit0142","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.32"},{"key":"cit0143","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068999"},{"key":"cit0144","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0502-505"},{"key":"cit0145","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.12.022"},{"key":"cit0146","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq460"},{"key":"cit0147","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm596"},{"issue":"6","key":"cit0148","doi-asserted-by":"crossref","first-page":"e0128618","DOI":"10.1371\/journal.pone.0128618","volume":"10","author":"Liu YP","year":"2015","journal-title":"PLoS One"},{"key":"cit0149","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00140-0"},{"key":"cit0150","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.22.11964-11972.2003"},{"key":"cit0151","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00165-5"},{"key":"cit0152","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.232688199"},{"key":"cit0153","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2006.07.007"},{"key":"cit0154","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2013.48"},{"key":"cit0155","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-6-55"},{"key":"cit0156","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.299"},{"key":"cit0157","doi-asserted-by":"publisher","DOI":"10.5501\/wjv.v1.i3.79"},{"key":"cit0158","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.5.2601-2605.2004"},{"key":"cit0159","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.2.571-577.2006"},{"key":"cit0160","first-page":"5447","volume":"9","author":"Woollard SM","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"cit0161","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3006"},{"key":"cit0162","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1565107"},{"key":"cit0163","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152725"},{"key":"cit0164","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.032"},{"key":"cit0165","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.10.004"},{"key":"cit0166","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.570341"},{"key":"cit0167","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000437"},{"key":"cit0168","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.07.110191.003015"},{"key":"cit0169","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2012.0407"},{"key":"cit0170","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn068"},{"key":"cit0171","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.03.010"},{"key":"cit0172","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl1022"},{"key":"cit0173","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01257-10"},{"key":"cit0174","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.10.011"},{"key":"cit0175","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2000.0116"},{"key":"cit0176","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5466.669"},{"key":"cit0177","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070104"},{"key":"cit0178","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-012017-043332"},{"key":"cit0179","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35700"},{"key":"cit0180","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.55"},{"key":"cit0181","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0106-0"},{"key":"cit0182","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233151"},{"key":"cit0183","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171242"},{"key":"cit0184","doi-asserted-by":"publisher","DOI":"10.1038\/nature09328"},{"key":"cit0185","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.09.008"},{"key":"cit0186","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-447250"},{"key":"cit0187","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608138103"},{"key":"cit0188","doi-asserted-by":"publisher","DOI":"10.1086\/589289"},{"key":"cit0189","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.21.11531-11535.2003"},{"key":"cit0190","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.03.027"},{"key":"cit0191","doi-asserted-by":"publisher","DOI":"10.7150\/thno.15246"},{"key":"cit0192","doi-asserted-by":"publisher","DOI":"10.3390\/v5112898"},{"key":"cit0193","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300662"},{"key":"cit0194","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817426"},{"key":"cit0195","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1405805"},{"key":"cit0196","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300382"},{"key":"cit0197","doi-asserted-by":"publisher","DOI":"10.1038\/nature04791"},{"key":"cit0198","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2013.76"},{"key":"cit0199","doi-asserted-by":"publisher","DOI":"10.1080\/21541264.2017.1322170"},{"key":"cit0200","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.41"},{"key":"cit0201","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq299"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2022.2117296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T10:27:49Z","timestamp":1679653669000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2022.2117296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,15]]},"references-count":201,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,1]]}},"alternative-id":["10.1080\/17460441.2022.2117296"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2022.2117296","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,15]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}