{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:55:41Z","timestamp":1791320141086,"version":"4.3.1"},"reference-count":70,"publisher":"Informa UK Limited","issue":"6","funder":[{"name":"Development of an ensemble learning-based, multi-dimensional sensory impairment score to predict cognitive impairment in an elderly cohort of Southern Italy"},{"name":"the European Union \u2013 Next Generation EU \u2013 NRRP M6C2 \u2013 Investment 2.1 Enhancement and Strengthening Biomedical Research within the NHS","award":["PNRR-MAD-2022-12376656"],"award-info":[{"award-number":["PNRR-MAD-2022-12376656"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2024,6,2]]},"DOI":"10.1080\/17460441.2024.2348142","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T05:04:13Z","timestamp":1714453453000},"page":"639-647","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":17,"title":["Lessons learned from the failure of solanezumab as a prospective treatment strategy for Alzheimer\u2019s disease"],"prefix":"10.1080","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1674-9724","authenticated-orcid":false,"given":"Madia","family":"Lozupone","sequence":"first","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience \u201cDiBraiN\u201d, University of Bari Aldo Moro, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9880-0481","authenticated-orcid":false,"given":"Vittorio","family":"Dibello","sequence":"additional","affiliation":[{"name":"Dipartimento Interdisciplinare di Medicina, Clinica Medica e Geriatria \u201cCesare Frugoni\u201d, University of Bari Aldo Moro, Bari, Italy"},{"name":"Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Sardone","sequence":"additional","affiliation":[{"name":"Unit of Statistics and Epidemiology, Local Health Authority of Taranto, Taranto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Castellana","sequence":"additional","affiliation":[{"name":"Dipartimento Interdisciplinare di Medicina, Clinica Medica e Geriatria \u201cCesare Frugoni\u201d, University of Bari Aldo Moro, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Zupo","sequence":"additional","affiliation":[{"name":"Dipartimento Interdisciplinare di Medicina, Clinica Medica e Geriatria \u201cCesare Frugoni\u201d, University of Bari Aldo Moro, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Lampignano","sequence":"additional","affiliation":[{"name":"Local Healthcare Authority of Bari, ASL Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Bortone","sequence":"additional","affiliation":[{"name":"Local Healthcare Authority of Bari, ASL Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Stallone","sequence":"additional","affiliation":[{"name":"Neuroscience and Education, Human Resources Excellence in Research, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Altamura","sequence":"additional","affiliation":[{"name":"Psychiatric Unit, Department of Clinical &amp; Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Bellomo","sequence":"additional","affiliation":[{"name":"Psychiatric Unit, Department of Clinical &amp; Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Daniele","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Catholic University of Sacred Heart, Rome, Italy"},{"name":"Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Solfrizzi","sequence":"additional","affiliation":[{"name":"Dipartimento Interdisciplinare di Medicina, Clinica Medica e Geriatria \u201cCesare Frugoni\u201d, University of Bari Aldo Moro, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7220-0656","authenticated-orcid":false,"given":"Francesco","family":"Panza","sequence":"additional","affiliation":[{"name":"Dipartimento Interdisciplinare di Medicina, Clinica Medica e Geriatria \u201cCesare Frugoni\u201d, University of Bari Aldo Moro, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-36"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25410"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-022-01308-6"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25513"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.02.002"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.2909"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0553-5"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720511798192718"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304839"},{"key":"e_1_3_5_14_1","volume-title":"In: StatPearls [Internet]","author":"Padda IS","year":"2023","unstructured":"Padda IS, Parmar M. Aducanumab. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023."},{"key":"e_1_3_5_15_1","unstructured":"U.S. Food and Drug Administration. FDA grants accelerated approval for Alzheimer\u2019s drug. Available from: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-grants-accelerated-approval-alzheimers-disease-treatment"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00813-8"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-023-01331-1"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_3_5_20_1","unstructured":"U.S. Food and Drug Administration to Convene Advisory Committee Meeting to discuss the TRAILBLAZER-ALZ 2 study of Donanemab. Available from: https:\/\/investor.lilly.com\/news-releases\/news-release-details\/us-food-and-drug-administration-convene-advisory-committee"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2024.2325551"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.11.93"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112834"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09649"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1290-2"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1489-x"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/373523a0"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/78682"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn842"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151261398"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067568"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)65184-x"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199912)46:6<860:aid-ana8>3.0.co;2-m"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.261562998"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6463fje"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2021-09.2009"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4742-11.2012"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.09.224"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3181cb577a"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312889"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.10.001"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705971"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.50.1.136"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.06.1893"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.05.007"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13031"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12313"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.07.005"},{"key":"e_1_3_5_49_1","unstructured":"Washington University School of Medicine in St. Louis. Investigational drugs didn\u2019t slow memory loss cognitive decline in rare inherited Alzheimer\u2019s initial analysis indicates. [cited 2024 Feb 5]. Available from: https:\/\/medicine.wustl.edu\/news\/alzheimers-diantu-trial-initial-results"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.038028"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01369-8"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1701047"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.803"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007941"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2305032"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.0387"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106631"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22628"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090366"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.06.005"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02196-w"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1151"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511018200"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.7437"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25395"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1123"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25600"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007248"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00550-7"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2023.2200245"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.363185"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2024.2348142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T20:23:49Z","timestamp":1727209429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2024.2348142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":70,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,2]]}},"alternative-id":["10.1080\/17460441.2024.2348142"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2024.2348142","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,29]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}