{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T12:52:23Z","timestamp":1787403143840,"version":"build-2736575974"},"reference-count":37,"publisher":"Informa UK Limited","issue":"11","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2025,11,2]]},"DOI":"10.1080\/17460441.2025.2556863","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T14:43:48Z","timestamp":1757083428000},"page":"1369-1376","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["<i>In silico<\/i>\n                    trials in ocular drug development: a new frontier in ophthalmology"],"prefix":"10.1080","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-7456","authenticated-orcid":false,"given":"Georgios D.","family":"Panos","sequence":"first","affiliation":[{"name":"AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]},{"name":"University of Nottingham","place":["Nottingham, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon N.","family":"Dutton","sequence":"additional","affiliation":[{"name":"Glasgow Caledonian University","place":["Glasgow, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Empeslidis","sequence":"additional","affiliation":[{"name":"Stoneygate Eye Hospital","place":["Leicester, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios-Georgios","family":"Konstas","sequence":"additional","affiliation":[{"name":"AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.2451"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.05.035"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.256933"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623307310955"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bby043"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104851"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9691-3"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2024.09.001"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02648045"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-017-9562-9"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.65.11.28"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/2516-1091\/acc8a9"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-024-03001-7"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1434241"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/photonics9110810"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3791"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-05002-w"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05905-z"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10010028"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.05.032"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4051785"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/17469899.2022.2130249"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M074088"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1147729"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2025.111303"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsysb.2023.1174647"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.25125"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00285-020-01544-4"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189053"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12322"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003528"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2023.101222"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2017.11.009"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2016.0136"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-024-01073-0"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202507569"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2025.2556863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:54:09Z","timestamp":1762149249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2025.2556863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,6]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,2]]}},"alternative-id":["10.1080\/17460441.2025.2556863"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2025.2556863","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}