{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:58:59Z","timestamp":1790866739073,"version":"4.1.0"},"reference-count":29,"publisher":"Informa UK Limited","issue":"10","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2026,10,3]]},"DOI":"10.1080\/17460441.2026.2733199","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:41:09Z","timestamp":1789710069000},"page":"1043-1049","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Incentivizing challenging drug discovery: from reducing failure to quantifying uncertainty"],"prefix":"10.1080","volume":"21","author":[{"given":"Stefano","family":"Moro","sequence":"first","affiliation":[{"name":"University of Padova","place":["Padova, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2786"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhealeco.2016.01.012"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3681"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3078"},{"key":"e_1_3_5_7_1","volume-title":"Uncertainty and profit","author":"Risk KFH","year":"1921","unstructured":"Risk KFH. Uncertainty and profit. Boston (MA): Houghton Mifflin; 1921."},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.2307\/1884324"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104009"},{"key":"e_1_3_5_10_1","unstructured":"ClinicalTrials.gov. Study evaluating rentosertib (INS018_055) administered orally in patients with idiopathic pulmonary fibrosis (IPF). Identifier: NCT07687459. Bethesda (MD): U.S. National Library of Medicine; 2026. [Available from]. 2026 Jul 7: Available from https:\/\/clinicaltrials.gov\/study\/NCT07687459"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4609"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4309"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.244"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3314"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008489"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0024-5"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0224-x"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.05.016"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.09.022"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.08.030"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02143-0"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03743-2"},{"key":"e_1_3_5_24_1","first-page":"1321","article-title":"On calibration of modern neural networks","volume":"70","author":"Guo C","year":"2017","unstructured":"Guo C, Pleiss G, Sun Y, et al. On calibration of modern neural networks. Proc Mach Learn Res. 2017;70:1321\u20131330. \u2022 Shows modern neural networks are frequently miscalibrated.","journal-title":"Proc Mach Learn Res"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.7b00403"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.12.009"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12796"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054013"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60312-2"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147215"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio0709-436"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2026.2733199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/17460441.2026.2733199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2026.2733199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:36:23Z","timestamp":1790865383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2026.2733199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,3]]}},"alternative-id":["10.1080\/17460441.2026.2733199"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2026.2733199","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}