{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T23:11:31Z","timestamp":1756681891211},"reference-count":26,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Sport Science"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate the expression of cardiac strain and damage in 18\u00a0male marathoners with average age of 52.8\u00b15.0 years running at a 308\u00a0km ultra\u2010marathon. Blood samples were collected at pre\u2010race, 100\u00a0km, 200\u00a0km and 308\u00a0km check points for the analysis of cardiac muscle injury markers, creatine kinase (CK), creatine kinase\u2013myocardial band (CK\u2013MB), cardiac troponin I (cTnI) and cardiac muscle strain marker, N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP). The CK levels increased 1127.2\u00b1507.9 IU\/L, 5133.8\u00b12492.7 IU\/L and 4958.4\u00b12087.9 IU\/L at 100\u00a0km, 200\u00a0km and 308\u00a0km, respectively, compared to the pre\u2010race levels. The CK\u2013MB levels increased 20.2\u00b111.2\u00a0ng\/mL, 73.3\u00b135.6\u00a0ng\/mL and 68.6\u00b142.6\u00a0ng\/mL at 100, 200 and 308\u00a0km, respectively, compared to the pre\u2010race levels. The CK\u2013MB\/CK ratio showed that the CK\u2013MB mass index was within the normal range (&lt;2.5%) at 100\u00a0km, 200\u00a0km and 308\u00a0km. The cTnI levels showed no significant difference in all check points. The NT\u2010proBNP levels increased 146.55\u00b192.7 pg\/mL, 167.95\u00b1111.9 pg\/mL and 241.23\u00b1121.2 pg\/mL at 100, 200 and 308\u00a0km, respectively, compared to the pre\u2010race levels. The normal CK\u2013MB mass index (&lt;5.0\u00a0ng\/mL) and the absence of an increase in the cTnI levels during the 308\u00a0km ultra\u2010marathon suggested that no myocardial injury despite an elevation in CK\u2013MB. The increase in NT\u2010proBNP levels probably resulted from continuous hemodynamic cardiac stress and represents a transient physiological myocardial protective response.<\/jats:p>","DOI":"10.1080\/17461391.2011.654267","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T09:31:08Z","timestamp":1331199068000},"update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":25,"title":["The effects of running a 308\u00a0km ultra\u2010marathon on cardiac markers"],"prefix":"10.1002","volume":"14","author":[{"given":"Young\u2010Joo","family":"Kim","sequence":"first","affiliation":[{"name":"Inje University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Oh","family":"Shin","sequence":"additional","affiliation":[{"name":"Soonchunhyang University Cheonan Republic of 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